Genetic News and Research

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Study shows rats, mice perform similarly in cognitive tests; offers implications for cognition research

It's one of those ideas that seems to make perfect sense: the bigger the brain, the more intelligent the creature.

9 Oct 2014

CTCs in blood of metastatic cancer patients give genomic read-out of breast cancer

The genetic fingerprint of a metastatic cancer is constantly changing, which means that the therapy that may have stopped a patient's cancer growth today, won't necessarily work tomorrow.

9 Oct 2014

Isis Pharmaceuticals secures $18 million from GSK to advance ISIS-TTR Rx Phase 2/3 study

Isis Pharmaceuticals, Inc. announced today that it has earned an $18 million milestone payment from GlaxoSmithKline related to the advancement of the Phase 2/3 study of ISIS-TTRRx in patients with familial amyloid polyneuropathy (FAP).

9 Oct 2014

Specific perceptual learning deficit associated with Fragile X Syndrome

Researchers at Children's Hospital Los Angeles have described for the first time a specific perceptual learning deficit in mice with a mutation of the same gene as found in children with Fragile X Syndrome (FXS).

9 Oct 2014

New model predicts replication rate in genome-wide studies based on SNP characteristics

To reduce false positives when identifying genetic variations associated with human disease through genome-wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

9 Oct 2014

Kansas State professor aims to develop vaccines to protect against tick-borne diseases

A Kansas State University professor is researching ways to keep animals and humans safe from tick-borne diseases.

9 Oct 2014

Discovery could lead to treatments for alcohol-related liver diseases

Researchers at the University of Missouri School of Medicine have identified epigenetic protein changes caused by binge drinking, a discovery that could lead to treatments for alcohol-related liver diseases.

9 Oct 2014

BRCA mutations carry risks for salivary gland cancer, breast cancer

The risk of developing cancer in a salivary gland might be higher in people with mutations in either of two genes associated with breast and ovarian cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

9 Oct 2014

TGen, NAU awarded patent for genomics-based test to detect H1N1 pandemic flu strain

The federal government has awarded a patent to the Translational Genomics Research Institute and Northern Arizona University for a test that can detect — and assist in the treatment of — the H1N1 pandemic flu strain.

9 Oct 2014

UCI to receive $8 million from NIH to study brain cell activity in motor neuron disorders

UC Irvine will receive $8 million from the National Institutes of Health to establish one of six national centers dedicated to creating a database of human cellular responses that will accelerate efforts to develop new therapies for many diseases.

9 Oct 2014

AT2101 drug, evaluated for Gaucher disease, slows progression of Parkinson's disease in mice

A new study from UCLA found that a drug being evaluated to treat an entirely different disorder helped slow the progression of Parkinson's disease in mice.

9 Oct 2014

New study reveals mechanism that compromises chromosome stability

During cell division, chromosomes acquire a characteristic X-shape with the two DNA molecules (sister chromatids) linked at a central "connection region" that contains highly compacted DNA.

9 Oct 2014

Researchers generate fruit fly model, unveil key genetic factors behind human colon cancer

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have managed to generate a fruit fly (Drosophila melanogaster) model that reproduces human colon cancer. With two publications appearing in PLoS One and EMBO Reports, the IRB team also unveil the function of a key gene in the development of the disease.

9 Oct 2014

Researchers use computer based predictions to combat AIDS

The battle against AIDS cannot be won in the laboratory alone. To fight the potentially deadly virus that 34 million people are suffering from we need help from computers.

8 Oct 2014

GenomOncology, med fusion partner to optimize treatment strategies for tumor

med fusion, an integrated molecular center of excellence and clinical trials service organization and GenomOncology, an Ohio based genomics technology and services provider, today announced a partnership to optimize treatment strategies based on the patient's disease state and tumor profile.

8 Oct 2014

Low sexual desire among women can be treatable

Low sexual desire is common among both pre- and post-menopausal women. It can cause personal distress, harm relationships, and have a negative impact on body image and self confidence. Yet few women seek medical care for this condition, and the reasons are explored in a timely article in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.

8 Oct 2014

Research finding could potentially lead to new strategies to improve cancer therapies

Cells are generally able to repair spontaneous damage that arises in their genetic material. Unfortunately, the DNA repair process is not perfect and sometimes, damaged DNA gets passed on to newly made cells. A team of researchers at the Center for Molecular Biology of Heidelberg University has recently discovered that in yeast cells, the amount of nutrients that cells are exposed to can affect DNA surveillance and repair mechanisms and therefore the quality of their DNA.

8 Oct 2014

Case Western Reserve researcher lands Director's New Innovator Awards from NIH

For the second consecutive year, a Case Western Reserve University School of Medicine researcher has landed one of the year's much-coveted Director's New Innovator Awards from the National Institutes of Health. Principal investigator Rong Xu, PhD, assistant professor of medical informatics, will receive $2,377,000 for five years, starting immediately, to initiate computational analysis of thousands of drugs and their effects.

8 Oct 2014

Two UCSD professors of psychiatry honored for schizophrenia research

Two professors of psychiatry at University of California, San Diego School of Medicine have been honored by the New York City-based Brain & Behavior Research Foundation for their work studying the genetics, dysfunction and treatment of schizophrenia, a chronic and severe brain disorder affecting roughly 1 percent of the general population or approximately 3 million people.

8 Oct 2014

Researchers demonstrate involvement of ClpB protein in eating disorders

Eating disorders (ED) such as anorexia nervosa, bulimia, and binge eating disorder affect approximately 5-10% of the general population, but the biological mechanisms involved are unknown. Researchers at Inserm Unit 1073, "Nutrition, inflammation and dysfunction of the gut-brain axis" (Inserm/University of Rouen) have demonstrated the involvement of a protein produced by some intestinal bacteria that may be the source of these disorders.

7 Oct 2014

Genetic News and Research

Study shows rats, mice perform similarly in cognitive tests; offers implications for cognition research

CTCs in blood of metastatic cancer patients give genomic read-out of breast cancer

Isis Pharmaceuticals secures $18 million from GSK to advance ISIS-TTR Rx Phase 2/3 study

Specific perceptual learning deficit associated with Fragile X Syndrome

New model predicts replication rate in genome-wide studies based on SNP characteristics

Kansas State professor aims to develop vaccines to protect against tick-borne diseases

Discovery could lead to treatments for alcohol-related liver diseases

BRCA mutations carry risks for salivary gland cancer, breast cancer

TGen, NAU awarded patent for genomics-based test to detect H1N1 pandemic flu strain

UCI to receive $8 million from NIH to study brain cell activity in motor neuron disorders

AT2101 drug, evaluated for Gaucher disease, slows progression of Parkinson's disease in mice

New study reveals mechanism that compromises chromosome stability

Researchers generate fruit fly model, unveil key genetic factors behind human colon cancer

Researchers use computer based predictions to combat AIDS

GenomOncology, med fusion partner to optimize treatment strategies for tumor

Low sexual desire among women can be treatable

Research finding could potentially lead to new strategies to improve cancer therapies

Case Western Reserve researcher lands Director's New Innovator Awards from NIH

Two UCSD professors of psychiatry honored for schizophrenia research

Researchers demonstrate involvement of ClpB protein in eating disorders

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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