Clinical Trial News and Research

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Understanding the role of genetic variants in male infertility

Approximately one in seven couples face difficulties conceiving a child naturally. Half of these cases are due to male infertility – either caused by the complete absence or low number of mature sperm.

13 Apr 2024

Study shows exercise can reverse age-related lipid accumulation

Scientists have discovered that a type of fat accumulates as tissue ages and that this accumulation can be reversed through exercise.

13 Apr 2024

Vosoritide's first phase 2 study shows increased growth in children with hypochondroplasia

Vosoritide's first global phase 2 study showed an average increased growth rate of 1.8 cm per year in children with hypochondroplasia, a genetic cause of short stature in children, according to researchers from Children's National Hospital.

13 Apr 2024

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances.

13 Apr 2024

Hypoglossal nerve stimulation offers hope for pediatric Down syndrome patients with OSA

While Obstructive Sleep Apnea (OSA) affects about five percent of the general pediatric population, 80 percent of children with Down syndrome experience OSA. Continual OSA results in poor health, including disruptions to cognitive development and functioning, leading physician-researchers from Mass General Brigham to investigate better methods to treat these patients as early as possible to maximize their health outcomes.

12 Apr 2024

Innovative cancer treatment approach yields promising results in pediatric patients

Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples.

12 Apr 2024

Low dose esketamine injection after childbirth reduces postpartum depression

A single low dose injection of esketamine given immediately after childbirth reduces major depressive episodes in individuals with depressive symptoms during pregnancy (prenatal depression), finds a clinical trial published by The BMJ today.

12 Apr 2024

Transcranial direct current stimulation shows promise for treating depression, anxiety in older adults

A noninvasive brain stimulation treatment improved depression and anxiety symptoms among older adults in a new University of Florida-led study.

12 Apr 2024

New sleep-enhancing nutraceutical blend falls short in clinical trial

Study investigates the impact of a unique nutraceutical blend, combining L-theanine with valerian, saffron, and lemon balm extracts, on improving sleep quality, finding no significant difference compared to a placebo in individuals experiencing poor sleep.

10 Apr 2024

New natural supplement shows promise in preventing postpartum blues

A new study published in the Lancet discovery science journal eClinicalMedicine has confirmed that a novel natural supplement - invented, researched, developed and commercialized at the Centre for Addiction and Mental Health (CAMH) - prevents postpartum blues, and reduces symptoms of postpartum depression over the following six months after giving birth.

10 Apr 2024

Three early-phase clinical studies show promising initial data for patients with lymphoma, gastric cancers

Three early-phase clinical studies presented by researchers from The University of Texas MD Anderson Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2024 show promising initial data for patients with lymphoma, gastric or gastroesophageal junction cancers, and specific molecularly selected tumors.

10 Apr 2024

Deciphering cancer plasticity:Insights from MSK research

About 90% of deaths from cancer are a result of metastasis - that is, from cancer's ability to spread from an initial primary tumor to seed new tumors throughout the body, often in the lungs, liver, and brain.

10 Apr 2024

Home-administered nasal spray could be safely used to treat recurrent rapid heart rhythms

A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms.

9 Apr 2024

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Adding a personalized anti-tumor vaccine to standard immunotherapy is safe and about twice as likely to shrink cancer as standard immunotherapy alone for patients with hepatocellular carcinoma, the most common type of liver cancer, according to a clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center and its Convergence Institute.

8 Apr 2024

Immersive VR may be a useful non-medication strategy to improve cancer pain

A 10-minute virtual reality (VR) session significantly lessened pain in hospitalized patients with cancer in a recent clinical trial published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Even a day later, participants experienced sustained benefits.

8 Apr 2024

New cryoablation technique eliminates ventricular tachycardia in 94% of patients

A new technology using ultralow temperature cryoablation (ULTC) has eliminated clinical ventricular tachycardia (VT) in 94% of patients. The late-breaking science is presented at EHRA 2024, a scientific congress of the European Society of Cardiology (ESC).

8 Apr 2024

Study shows reduced bleeding risk with ticagrelor monotherapy after percutaneous coronary intervention

People who have had a heart attack or who are at risk for a heart attack and who stopped taking aspirin alongside the P2Y12 inhibitor ticagrelor one month after undergoing percutaneous coronary intervention (PCI) saw a significantly reduced risk of clinically meaningful bleeding with no increased risk of clotting-related adverse events at 12 months compared with patients who continued taking aspirin and ticagrelor for a full year, in a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Ten doctors on FDA panel reviewing Abbott heart device had financial ties with company

When the FDA recently convened a committee of advisers to assess a cardiac device made by Abbott, the agency didn't disclose that most of them had received payments from the company or conducted research it had funded — information readily available in a federal database.

8 Apr 2024

Pioneering vaccine strategy promises to outmaneuver antimicrobial resistance

Study introduces Reverse Vaccine Development as a strategic approach to identify correlates of protection early in vaccine development against antimicrobial-resistant pathogens, aiming to mitigate risks such as significant phase-III clinical trial failures.

7 Apr 2024

Behavioral economics strategies boost daily walking by 10% in high-risk cardiovascular patients

Strategies such as earning points or small amounts of money encouraged people at high risk for heart disease or stroke to increase their daily walking by about 10% and sustain the increase for a year, according to research being presented at the American College of Cardiology's Annual Scientific Session.

7 Apr 2024

Clinical Trial News and Research

Understanding the role of genetic variants in male infertility

Study shows exercise can reverse age-related lipid accumulation

Vosoritide's first phase 2 study shows increased growth in children with hypochondroplasia

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

Hypoglossal nerve stimulation offers hope for pediatric Down syndrome patients with OSA

Innovative cancer treatment approach yields promising results in pediatric patients

Low dose esketamine injection after childbirth reduces postpartum depression

Transcranial direct current stimulation shows promise for treating depression, anxiety in older adults

New sleep-enhancing nutraceutical blend falls short in clinical trial

New natural supplement shows promise in preventing postpartum blues

Three early-phase clinical studies show promising initial data for patients with lymphoma, gastric cancers

Deciphering cancer plasticity:Insights from MSK research

Home-administered nasal spray could be safely used to treat recurrent rapid heart rhythms

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Immersive VR may be a useful non-medication strategy to improve cancer pain

New cryoablation technique eliminates ventricular tachycardia in 94% of patients

Study shows reduced bleeding risk with ticagrelor monotherapy after percutaneous coronary intervention

Ten doctors on FDA panel reviewing Abbott heart device had financial ties with company

Pioneering vaccine strategy promises to outmaneuver antimicrobial resistance

Behavioral economics strategies boost daily walking by 10% in high-risk cardiovascular patients

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