Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Cathepsin Z protein regulates metastasis of pancreatic cancer

Researchers at Queen Mary, University of London have identified a new protein that makes pancreatic cancer cells less 'sticky' and therefore less able to attach to and invade other tissue.

26 Mar 2012

AACR to honor PU professor with Award for Outstanding Achievement in Cancer Research

A researcher from The Cancer Institute of New Jersey (CINJ) and Princeton University who is helping to advance the molecular understanding of cancer metastasis is being recognized for his work by cancer specialists from around the globe.

22 Mar 2012

Aspirin may prevent cancer metastasis and halt its progress: Study

Aspirin has numerous benefits. It is already known that it may prevent cancer. Research shows it may also be an effective treatment for halting the disease once it has started. An analysis of five large trials of people who took a daily low dose aspirin showed that among those who developed cancer it reduced its spread to distant organs by 40 to 50 per cent.

21 Mar 2012

Women with denser breasts may have increased risk of cancer recurrence

Women aged 50 and over with breasts that have a high percentage of dense tissue are at greater risk of their breast cancer recurring, according to Swedish research presented at the eighth European Breast Cancer Conference (EBCC-8) in Vienna.

21 Mar 2012

Two awards to advance pancreatic cancer research

The Pancreatic Cancer Action Network and the American Association for Cancer Research have awarded Stephanie K. Dougan, Ph.D., postdoctoral fellow at the Whitehead Institute for Biomedical Research, and Oliver G. McDonald, M.D., Ph.D., postdoctoral fellow at Johns Hopkins University, the 2012 Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants.

16 Mar 2012

Study provides insight into developing new treatment strategies for triple-negative breast cancer

A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated with early metastasis and resistance to chemotherapy and occurs at women at a younger age.

15 Mar 2012

Cadherin-23 might play a role in earliest stages of breast cancer metastasis

Rensselaer Polytechnic Institute Biologist Lee Ligon has found a previously unknown connection between breast cancer tumor cells and the surrounding healthy tissue. The results provide new information on the earliest stages of breast cancer metastasis.

15 Mar 2012

Modified Citrus Pectin binds and blocks harmful effects of Galectin-3

Galectin-3 sounds like a planet out of "Star Trek," but it can be much more ominous. Recently, distinguished integrative physician Isaac Eliaz, M.D., presented breakthrough research demonstrating that the protein Galectin-3 is an active biomarker for numerous life-threatening diseases. Even more importantly, Dr. Eliaz showed how Modified Citrus Pectin (MCP) binds and blocks Galectin-3 throughout the body.

14 Mar 2012

RhoGDI2 protein helps prevent bladder cancer metastasis to the lungs

The diagnosis of localized bladder cancer carries an 80 percent five-year survival rate, but once the cancer spreads, the survival rate at even three years is only 20 percent. A major study published today in the Journal of Clinical Investigation not only shows how bladder cancer metastasizes to the lungs but pinpoints a method for stopping this spread.

13 Mar 2012

Level IIb nodes can be avoided during SND for laryngeal squamous cell carcinoma

Metastasis of tumors to level IIb lymph nodes is rare in patients with laryngeal squamous cell carcinoma (LSCC); this area can be ignored during selective neck dissection (SND) to avoid damaging the spinal accessory nerve (SAN), making this surgery more conservative and minimizing SAN morbidity, according to the March 2012 issue of Otolaryngology-Head and Neck Surgery.

12 Mar 2012

Tumors can be more complex than imagined earlier: Study

Researchers speculate that cancers may be more complex that they knew. And that's why a single tissue sample taken from a single tumor may not be the best way to figure out a course of treatment they claim.

11 Mar 2012

Researchers make significant strides in the study of Intrahepatic Cholangiocarcinoma

Researchers at the University of Rochester Medical Center's James P. Wilmot Cancer Center have made significant strides in the study of a primary cancer of the liver- Intrahepatic Cholangiocarcinoma (IHCC), also called biliary tract cancer.

8 Mar 2012

Study identifies mechanism that explains how cancer cells spread to the lymph nodes

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the mechanisms responsible for this process is one of the top goals of cancer research. The metastatic process involves a series of steps chained where the primary tumour invades surrounding tissues and ends spreading throughout the body. Ones of the first tissues undergoing metastasis are the lymph nodes surrounding the tumour.

7 Mar 2012

Scripps scientists to develop new generation of broad spectrum anti-cancer therapeutics

A pair of Scripps Research Institute scientists, one a cancer biologist and the other a chemist, has been awarded $3.85 million from the National Institutes of Health (NIH) to develop a new generation of broad spectrum anti-cancer therapeutics, including breast cancer and lymphoma.

6 Mar 2012

Blocking Plexin B1 protein can prevent formation of breast cancer metastases

In particularly aggressive forms of breast cancer, cancer cells can settle in other organs and form metastases there. Once such metastases form, complete recovery is rare. Consequently, it is enormously important to prevent the metastasisation of the breast cancer cells. The success, however, achieved by using existing forms of therapy is limited.

6 Mar 2012

Exelixis initiates cabozantinib and abiraterone phase 1 combination trial in CRPC

Exelixis Inc. today announced the initiation of a phase 1 dose-finding trial of cabozantinib in combination with abiraterone in men with metastatic castration-resistant prostate cancer (CRPC) who have disease progression following treatment with up to two prior chemotherapy regimens.

5 Mar 2012

Combination of implanted DCs and EBRT effective in creating sarcoma tumor immune response

A team of 18 researchers at Moffitt Cancer Center in Tampa, Fla., have found that treating high-risk, soft tissue sarcoma patients with a combination of implanted dendritic cells (immune system cells) and fractionated external beam radiation (EBRT) provided more than 50 percent of their trial patients with tumor-specific immune responses lasting from 11 to 42 weeks.

2 Mar 2012

New HS44 molecule inhibits lung metastasis

One type of white blood cell, the Natural Killer T Cells, fights against infections and tumours by freeing cytokine proteins which activate the body's immune response and destroy infected or malignant cells. To do so they must receive an activation signal. Specific receptors located on their surface act as switches: they activate the lymphocyte in presence of an antigen, a molecule which triggers alarm signals.

2 Mar 2012

Two-target approach may effectively stop pancreatic cancer metastasis

Simultaneous targeting of two different molecules in cancer is an effective way to shrink tumors, block invasion, and stop metastasis, scientists at the University of California, San Francisco (UCSF) have found—work that may improve the effectiveness of combination treatments that include drugs like Avastin.

27 Feb 2012

Cabozantinib blocks c-MET and VEGF signaling in mouse model of pancreatic cancer

Dual inhibition of vascular endothelial growth factor and c-MET signaling inhibited tumor invasion and metastasis in a laboratory model of pancreatic neuroendocrine cancer, according to a paper published in Cancer Discovery, the newest journal of the American Association for Cancer Research.