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FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Ionis Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration has granted Orphan Drug Designation to IONIS-HTTRx for the treatment of patients with Huntington's disease (HD).

5 Jan 2016

Ardelyx announces positive results from RDX022 clinical study for treatment of hyperkalemia

Ardelyx, Inc., a clinical-stage biopharmaceutical company focused on gastrointestinal and cardio-renal diseases, today announced positive results of an open label clinical study evaluating the pharmacodynamic (PD) activity of RDX022 in healthy adult volunteers.

5 Jan 2016

Study reveals promising mechanism for attacking Ebola virus

In late December, nearly two years after the epidemic began, the World Health Organization has declared the African country of Guinea to be free of Ebola virus infections. But, the race to find a cure and therapies to combat the disease are forging ahead as officials warn that inattention could lead to another epidemic.

5 Jan 2016

Drug-microbe interactions may contribute to adverse effects, lessen effectiveness of NSAID

A nonsteroidal anti-inflammatory drug (NSAID) changed the composition and diversity of gut microbes, which in turn shaped how the drug is broken down and ultimately, cut its effectiveness, according to an animal study from the Perelman School of Medicine at the University of Pennsylvania.

5 Jan 2016

Disease burden, health care costs higher in children with recurrent acute and chronic pancreatitis

The burden of recurrent acute and chronic pancreatitis in children may be higher than previously thought, with high costs related to repeated hospitalizations, report a pair of studies in the Journal of Pediatric Gastroenterology and Nutrition.

5 Jan 2016

FDA issues two final orders to strengthen requirements for transvaginal surgical mesh safety

The U.S. Food and Drug Administration today issued two final orders to manufacturers and the public to strengthen the data requirements for surgical mesh to repair pelvic organ prolapse (POP) transvaginally, or through the vagina.

5 Jan 2016

$New editorial calls on doctors to individualize treatment decisions based on patients' fracture risk$

New editorial calls on doctors to individualize treatment decisions based on patients' fracture risk

A new editorial published by an International Osteoporosis Foundation Working Group urges physicians to individualize treatment decisions based on their patients' fracture risk, rather than automatically interrupting or stopping bisphosphonate therapy after five or three years.

5 Jan 2016

Anticholinergic medications do not affect cognitive performance in PD patients

Recent evidence has shown a greater risk of dementia, in particular Alzheimer's disease (AD), in individuals using anticholinergic medications regularly. These drugs are widely used by older adults to treat bladder dysfunction, mood, and pain, and many of them are available without prescription.

5 Jan 2016

MUSC researchers receive PCORI grant to study safety, effectiveness of three blood-thinning drugs

A research team at the Medical University of South Carolina has been approved for a $13.5 million funding award by the Patient-Centered Outcomes Research Institute to study the safety and effectiveness of three blood-thinning drugs used to prevent potentially deadly blood clots in patients undergoing hip and knee replacement.

5 Jan 2016

Children conceived through infertility treatments no more likely to have developmental delays

Children conceived via infertility treatments are no more likely to have a developmental delay than children conceived without such treatments, according to a study by researchers at the National Institutes of Health, the New York State Department of Health and other institutions.

5 Jan 2016

Antiscarring paste can halt fibrosis caused by radiation treatment

An antiscarring paste when applied to the skin of mice halts fibrosis caused by the radiation used in cancer therapy. That is according to a study led by researchers at Laura and Isaac Perlmutter Cancer Center to be published tomorrow in the January edition of the Journal of the Federation of American Societies for Experimental Biology, or FASEB.

5 Jan 2016

New guide provides valuable, unique overview of key properties of different drug targets

The new Concise Guide to PHARMACOLOGY 2015/2016 provides a valuable and unique overview of the key properties of more than 1,700 human drug targets, focusing on those exploited currently in the clinic or with future therapeutic potential.

5 Jan 2016

Researchers discover methods for reducing age-related stem cell dysfunction, metabolic disease in aged mice

Mayo Clinic researchers have taken what they hope will be the first step toward preventing and reversing age-related stem cell dysfunction and metabolic disease. That includes diabetes, which affects 12.2 million Americans age 60 and older, according to the National Council on Aging.

5 Jan 2016

Sharp increase in drug shortages affects US emergency departments

A new study reveals that drug shortages affecting emergency care have skyrocketed in the United States in recent years. While the prevalence of such shortages fell from 2002 to 2007; the number of shortages sharply increased by 373% (from 26 to 123) from 2008 to 2014.

4 Jan 2016

High diversity among circulating tumor cells predicts survival, treatment resistance in prostate cancer patients

Research teams at Memorial Sloan Kettering Cancer Center and Epic Sciences have found that greater diversity among circulating tumor cells (CTCs) in the blood of advanced prostate cancer patients predicts not only shorter overall survival, but also the development of resistance to key anti-androgen therapies.

4 Jan 2016

World's largest database for cancer drug discovery revolutionised by 3D techniques

THE world's largest database for cancer drug discovery has been revolutionised by adding 3D structures of faulty proteins and maps of cancer's communication networks, according to Cancer Research UK-funded research published in Nucleic Acid Research today (Monday).

4 Jan 2016

NCCLC patients with KRAS-related gene mutations may benefit from triple therapy

Although the most common type of lung cancer - non-small cell lung cancer (NSCLC) - has recently seen major treatment advances in some genetic subtypes, other subtypes continue to evade effective treatment. (New therapies exist for NCCLC patients whose cancers harbor mutations in the ALK or EGFR genes, for example.)

4 Jan 2016

MUSC researchers receive $1.68 million NIH grant to study better treatment for chronic pancreatitis, diabetes

MUSC researchers received a $1.68 million National Institutes of Health grant to explore a better treatment for chronic pancreatitis, with the hopes that it also may shed light on a future cure for patients with type 1 diabetes.

4 Jan 2016

Novel imaging-based method as accurate as current standard-of-care for breast cancer treatment

A new study shows that a novel imaging-based method for defining appropriateness of breast cancer treatment is as accurate as the current standard-of-care and could reduce the need for invasive tissue sampling. The results suggest that the method might lead to more optimal treatment of individual patients.

31 Dec 2015

Natural dietary supplement Arthrem significantly reduces pain and stiffness in osteoarthritis patients

New Zealand company Promisia Integrative Limited, announced today significant positive results from a clinical trial on their natural dietary supplement Arthrem. The results have been published in the December 2015 issue of Clinical Rheumatology, a prestigious international peer reviewed medical journal.

31 Dec 2015

Drugs News and Research

FDA grants Orphan Drug Designation to Ionis Pharmaceuticals' IONIS-HTT Rx for treatment of HD patients

Ardelyx announces positive results from RDX022 clinical study for treatment of hyperkalemia

Study reveals promising mechanism for attacking Ebola virus

Drug-microbe interactions may contribute to adverse effects, lessen effectiveness of NSAID

Disease burden, health care costs higher in children with recurrent acute and chronic pancreatitis

FDA issues two final orders to strengthen requirements for transvaginal surgical mesh safety

New editorial calls on doctors to individualize treatment decisions based on patients' fracture risk

Anticholinergic medications do not affect cognitive performance in PD patients

MUSC researchers receive PCORI grant to study safety, effectiveness of three blood-thinning drugs

Children conceived through infertility treatments no more likely to have developmental delays

Antiscarring paste can halt fibrosis caused by radiation treatment

New guide provides valuable, unique overview of key properties of different drug targets

Researchers discover methods for reducing age-related stem cell dysfunction, metabolic disease in aged mice

Sharp increase in drug shortages affects US emergency departments

High diversity among circulating tumor cells predicts survival, treatment resistance in prostate cancer patients

World's largest database for cancer drug discovery revolutionised by 3D techniques

NCCLC patients with KRAS-related gene mutations may benefit from triple therapy

MUSC researchers receive $1.68 million NIH grant to study better treatment for chronic pancreatitis, diabetes

Novel imaging-based method as accurate as current standard-of-care for breast cancer treatment

Natural dietary supplement Arthrem significantly reduces pain and stiffness in osteoarthritis patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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