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International panel of clinical experts comment on state of their fields

In an Editorial published this week in PLOS Medicine, editors ask an international panel of eleven expert researchers and clinicians spanning a range of specialties to answer questions on their field and what developments they hope and expect to see in 2016.

30 Dec 2015

New model provides images of single cell with micrometer resolution

Thermal properties of cells regulate their ability to store, transport or exchange heat with their environment. So gaining control of these properties is of great interest for optimizing cryopreservation -- the process of freezing and storing blood or tissues, which is also used when transporting organs for transplants.

30 Dec 2015

Treating multidrug-resistant tuberculosis with regimens may improve outcomes

Treating multidrug-resistant tuberculosis (MDR TB) with regimens that include a greater number of drugs may improve outcomes, and baseline drug susceptibility testing (DST) could identify drugs with the greatest likelihood of success, according to a paper published this week in PLOS Medicine.

30 Dec 2015

ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the Department of Energy's Oak Ridge National Laboratory.

30 Dec 2015

Delivering novel formulation of propranolol as liquid salt may reduce skin toxicity

Formulating drugs as liquid salts may provide a safe and efficient strategy for topical delivery of drugs that cause skin toxicity. A team of researchers from the University of California, Santa Barbara (UCSB) in Santa Barbara, CA has demonstrated a novel formulation of propranolol as a liquid salt which enables delivery through skin with reduced toxicity.

30 Dec 2015

Amarantus seeks FDA's Rare Pediatric Disease Designation and ODD to treat GCMN with Engineered Skin Substitute

Amarantus BioScience Holdings, Inc., a biotechnology company focused on developing products for Regenerative Medicine, Neurology and Orphan Diseases, announced that it has requested Rare Pediatric Disease Designation (RPDD) and Orphan Drug Designation (ODD) from the US Food and Drug Administration to treat GCMN with Engineered Skin Substitute (ESS).

30 Dec 2015

Several therapies for hemophilia A, hemophilia B and hemophilia with inhibitors to be launched between 2015-2025

Decision Resources Group forecasts that several therapies will launch for hemophilia A, hemophilia B and hemophilia with inhibitors in the United States and Europe during our 2015-2025 study period.

29 Dec 2015

Scientists pin down structure of neuronal protein clumps associated with ALS

To create treatments for a disease without any, scientists need to study and understand the driving forces behind the faulty biology. Today, researchers at the University of North Carolina School of Medicine announced the first-ever evidence-based description of the neuronal protein clumps thought to be important in Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, a fatal neurodegenerative condition.

29 Dec 2015

Infusing small dose of cytokine can prevent or reverse diabetes-related kidney failure

Diabetes is the leading cause of kidney failure, and scientists have found that infusing just a small dose of a cytokine, thought to help cause that failure, can instead prevent or reverse it.

29 Dec 2015

Microencapsulation method can help overcome challenges in pancreatic islet transplantation

A microencapsulation method, developed by OIST researchers, can help to overcome major challenges in pancreatic islet transplantation.

26 Dec 2015

Ebola virus and bats waging molecular battle for survival

Ebola virus and bats have been waging a molecular battle for survival that may have started at least 25 million years ago, according to a study led by researchers at Albert Einstein College of Medicine, the University of Colorado-Boulder (CU-Boulder) and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) that published online today in the journal eLife.

24 Dec 2015

Azithromycin remains effective in treatment of urogenital chlamydia, confirms UAB study

In one of the most tightly controlled trials ever conducted of drugs used to treat sexually transmitted infections, researchers at the University of Alabama at Birmingham have confirmed that azithromycin remains effective in the treatment of urogenital chlamydia.

24 Dec 2015

Positive interim results from TWIB's AC-201 CR Phase 2 study for hyperuricemia and gout

TWi Biotechnology Inc. today announced interim results from the ongoing Phase 2 proof of concept clinical study evaluating AC-201 CR as an oral uricosuric and anti-inflammatory agent for the treatment of hyperuricemia and prevention of gout flares combining with febuxostat, a xanthine oxidase inhibitor.

24 Dec 2015

Computers could discover future drugs

The drugs of tomorrow may be discovered by computers. A proof-of-concept study published December 23 in Cell Systems demonstrates that with the right input of data about infectious yeast, a machine algorithm can learn to identify combinations of existing and previously unknown compounds that can work together as antifungal agents.

24 Dec 2015

TEDA International Cardiovascular Hospital passes JCI and HIMSS Stage 7 assessment

On December 12, 2015, TEDA International Cardiovascular Hospital (TEDA) was validated by HIMSS Analytics with the Stage 7 Award, making it the first hospital in China which has passed JCI and HIMSS Stage 7 assessment at the same time.

24 Dec 2015

Sanofi seeks FDA NDA approval for once-daily fixed-ratio combination of insulin glargine and lixisenatide

Sanofi announced today that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for its investigational fixed-ratio combination of insulin glargine 100 Units/mL and lixisenatide, which if approved would be administered as a single daily injection for the treatment of adults with type 2 diabetes.

24 Dec 2015

Computer model analyses social networks to identify new ways to treat cancer

CANCER RESEARCH UK-funded scientists have designed a computer model that applies techniques used to analyse social networks to identify new ways of treating cancer, according to research published in PLOS Computational Biology.

24 Dec 2015

Researchers identify 124 protein targets of artemisinin in most pathogenic malaria parasite

A team of researchers from the National University of Singapore (NUS) has uncovered the mystery behind the potent parasite-killing effect of artemisinin, a drug that is considered to be the last line of defence against malaria. Given the emergence of artemisinin resistance, these findings could potentially lead to the design of new treatments against drug-resistant parasites.

24 Dec 2015

EMA CHMP considers AcelRx's ARX-04 for acute pain treatment for centralized review

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the intended treatment of acute pain, reported that the Committee for Medicinal Products for Human Use (CHMP) at the European Medicines Agency (EMA) has confirmed that a Marketing Authorization Application (MAA) for ARX-04 may be submitted in the European Union (EU) under the Agency's centralized procedure.

24 Dec 2015

ABC/VEN-analysis presents simple and effective method towards rational use of medicines

Rational use of medicines remains to be one of the most challenging problems in health systems worldwide. Kazan Federal University researchers conducted a practical study to assess the impact of introducing evidence-based principles to the practice of medicine procurement in order to manage budget expenditures on medicines of a multidisciplinary health facility for the period of 2011-2014.

23 Dec 2015

Drugs News and Research

International panel of clinical experts comment on state of their fields

New model provides images of single cell with micrometer resolution

Treating multidrug-resistant tuberculosis with regimens may improve outcomes

ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

Delivering novel formulation of propranolol as liquid salt may reduce skin toxicity

Amarantus seeks FDA's Rare Pediatric Disease Designation and ODD to treat GCMN with Engineered Skin Substitute

Several therapies for hemophilia A, hemophilia B and hemophilia with inhibitors to be launched between 2015-2025

Scientists pin down structure of neuronal protein clumps associated with ALS

Infusing small dose of cytokine can prevent or reverse diabetes-related kidney failure

Microencapsulation method can help overcome challenges in pancreatic islet transplantation

Ebola virus and bats waging molecular battle for survival

Azithromycin remains effective in treatment of urogenital chlamydia, confirms UAB study

Positive interim results from TWIB's AC-201 CR Phase 2 study for hyperuricemia and gout

Computers could discover future drugs

TEDA International Cardiovascular Hospital passes JCI and HIMSS Stage 7 assessment

Sanofi seeks FDA NDA approval for once-daily fixed-ratio combination of insulin glargine and lixisenatide

Computer model analyses social networks to identify new ways to treat cancer

Researchers identify 124 protein targets of artemisinin in most pathogenic malaria parasite

EMA CHMP considers AcelRx's ARX-04 for acute pain treatment for centralized review

ABC/VEN-analysis presents simple and effective method towards rational use of medicines

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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