Cell Nucleus News and Research

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New molecular insights may one day lead to opportunities to stave off old age

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

18 Jul 2005

NIPA levels act as switch regulating cell division

Cells control mitosis (cell division) by assembling a biochemical switch to block it or by disassembling the switch to trigger it, according to investigators at St. Jude Children's Research Hospital and the Technical University of Munich.

18 Jul 2005

Oxytocin raises aggression, cuts anxiety during lactation

Maternal aggressive/protective behavior is recognized throughout mammalian species, especially during lactation. When hiking, we warn our kids not to approach bear cubs, or to get between a cub and the mother. While driving and you see a fawn, you know a doe can't be too far away and will run headlong to protect it.

18 Jul 2005

New method may accelerate the way cancer-causing genes are found

Researchers at the University of Minnesota Cancer Center and the National Cancer Institute (NCI) have discovered a new method that could accelerate the way cancer-causing genes are found and could lead to a more accurate identification of the genes, according to two studies in the July 14, 2005, issue of Nature.

13 Jul 2005

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005

Reovirus-based therapy called "Reolysin" helps battle cancer

Researchers are now investigating how to make cancer cells "terminally ill" by giving a common reovirus to patients with various types of cancers.

28 Jun 2005

Researchers demonstrate direct transfer of terminally differentiated cell nuclei

With the advent of nuclear-transfer cloning, it is now possible to produce mice from the nuclei of differentiated cells, such as peripheral blood lymphocytes and olfactory sensory neurons.

20 Jun 2005

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Disruption of proteins expressed at the junctures between cells (known as tight junctions) is a hallmark of cancer cell invasion and spread (metastasis).

16 Jun 2005

Circadian clock gene also plays pivotal role in drug addiction

The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found.

13 Jun 2005

New understanding of jet lag

A new study demonstrates that the brain’s central timekeeper - the biological clock that regulates waking and sleeping cycles - has two parts that fall out of synchrony during light schedule shifts of six hours, the time it takes to fly across the Atlantic.

3 Jun 2005

Scientists have uncovered the structure of a network of proteins that help regulate the life cycle of cells

Scientists at Memorial Sloan-Kettering Cancer Center (MSKCC) have uncovered the structure of a network of proteins that help regulate the life cycle of cells. Understanding the network's physical layout is an important step toward learning its precise function, and in finding ways to correct flaws in the system that could lead to cancer.

2 Jun 2005

Scientists develop a way to block the signals responsible for neuropathic pain

Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it.

1 Jun 2005

Targeted Genetics issued patent related to adeno-associated virus (AAV) technology platform

Targeted Genetics Corporation has announced the issuance of another patent related to the Company's leading adeno-associated virus (AAV) technology platform. U.S. patent #6,897,045, titled "Adeno-Associated Virus Vectors," was issued to the University of Iowa Research Foundation and is exclusively licensed to Targeted Genetics.

30 May 2005

Protein, called "eed," crucial to the regulation of genes in embryonic stem cells

New research from University of North Carolina at Chapel Hill shows how a protein may be crucial to the regulation of genes in embryonic stem cells.

26 May 2005

Scientists show nuclear protein Ezh2 helps establish previously unknown signaling pathway in cells

Since 2001, scientists have wrestled with the discovery that there are fewer genes in humans than biological processes linked to those genes over the course of a human lifespan. One way to understand genetically coded events is by studying epigenetics, the regulation and heritability of genes at a cellular level due to molecular changes to the many proteins (called histones) that package DNA in a cell's nucleus.

23 May 2005

Researchers generate patient-specific stem cells

Researchers have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury.

20 May 2005

Basic brain mechanism that causes drug-seeking behavior

In studies with rats, researchers have distinguished a burst of the brain chemical dopamine from a reward-related brain region that is associated with anticipating the delivery of cocaine. The finding, publishing in the May 19 issue of Neuron, reveals the brain signal that likely underlies the fundamental motivation to obtain such drugs, said the scientists.

20 May 2005

Molecule found in liver cells could explain a lot about the relationship between diet, lipid levels in blood, and atherosclerosis

A team of researchers at the University of Pennsylvania School of Medicine have made a discovery that a molecule found in liver cells is important in explaining the relationship between diet, lipid levels in blood, and atherosclerosis.

15 May 2005

Research proves the dangers of salt

Sydney University scientists have proved that salt has a dangerous adrenalin-inducing effect on people suffering from high blood pressure, or 'hypertension'.

10 May 2005

Scientists extend the lifespan of mice

Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to the free-radical theory of aging.

5 May 2005

Cell Nucleus News and Research

New molecular insights may one day lead to opportunities to stave off old age

NIPA levels act as switch regulating cell division

Oxytocin raises aggression, cuts anxiety during lactation

New method may accelerate the way cancer-causing genes are found

Researchers clarifiy role of Notch protein in T-cell development

Reovirus-based therapy called "Reolysin" helps battle cancer

Researchers demonstrate direct transfer of terminally differentiated cell nuclei

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Circadian clock gene also plays pivotal role in drug addiction

New understanding of jet lag

Scientists have uncovered the structure of a network of proteins that help regulate the life cycle of cells

Scientists develop a way to block the signals responsible for neuropathic pain

Targeted Genetics issued patent related to adeno-associated virus (AAV) technology platform

Protein, called "eed," crucial to the regulation of genes in embryonic stem cells

Scientists show nuclear protein Ezh2 helps establish previously unknown signaling pathway in cells

Researchers generate patient-specific stem cells

Basic brain mechanism that causes drug-seeking behavior

Molecule found in liver cells could explain a lot about the relationship between diet, lipid levels in blood, and atherosclerosis

Research proves the dangers of salt

Scientists extend the lifespan of mice

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