Lipids News and Research

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Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.

Scientists demonstrate how glowing fish can help screen drugs that control metabolic disorders

A tiny, translucent zebrafish that glows green when its liver makes glucose has helped an international team of researchers identify a compound that regulates whole-body metabolism and appears to protect obese mice from signs of metabolic disorders.

2 Dec 2012

Membrane-proximal external region of HIV could be used to design vaccines

Beatriz Apellaniz, PhD holder of the UPV/EHU-University of the Basque Country, has studied in her PhD thesis HIV regions that could be used to design a vaccine. The researcher has focussed her research on a specific region of the surface protein of the Human Immunodeficiency Virus (HIV), which is responsible for the Autoimmune Deficiency Syndrome (AIDS), one of the diseases with the greatest human morbidity and mortality.

30 Nov 2012

Omega-3 fatty acids can benefit women at risk of postpartum depression

The "feel-good" hormone serotonin, depleted by pregnancy, can be replenished by adding sources of omega-3 to the diets of pregnant women and new mothers - a development particularly beneficial to the 10 to 15 percent of women at risk for postpartum depression, according to a recent University of Montreal study published in the latest edition of the Canadian Journal of Psychiatry.

29 Nov 2012

Arginase might play a role in development of cardiovascular disease in type II diabetics

In a new study published in the scientific journal Circulation, scientists at Karolinska Institutet and Karolinska University Hospital in Sweden show that an enzyme called arginase might have a key part to play in the development of cardiovascular disease in patients who already have type II diabetes.

27 Nov 2012

Diabetes can remit after gastric bypass surgery

After gastric bypass surgery, diabetes goes away for some people-often even before they lose much weight. So does that mean gastric surgery "cures" diabetes? Not necessarily, according to the largest community-based study of long-term diabetes outcomes after bariatric surgery.

27 Nov 2012

Grove professor to investigate personalized therapies against breast cancer

For some time, researchers have known about disparities in diagnoses and outcomes among breast cancer patients based on race and age. However, they have been challenged to develop a set of criteria that can be used to reliably target drug delivery mechanisms based on an individual patient's tumor.

27 Nov 2012

Computational apolipoprotein estimates ‘reliable’ for cardiovascular risk

Computational estimates of apolipoprotein B and apolipoprotein A1 can be used as reliable markers for atherosclerosis, report researchers.

22 Nov 2012

Computational apolipoprotein estimates ‘reliable’ for CV risk

Computational estimates of apolipoprotein B and apolipoprotein A1 can be used as reliable markers for atherosclerosis, report researchers.

21 Nov 2012

Emory University, Georgia Tech to establish Malaria Host-Pathogen Interaction Center

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded a five-year contract of up to $19.4 million, depending on contract options exercised, to establish the Malaria Host-Pathogen Interaction Center (MaHPIC).

20 Nov 2012

Study on genetic capacity of diverse populations to make critical PUFAs

World-renowned scientists are taking what they've learned from their multicenter research collaboration studying the health impact of fatty acids on diverse populations to set up a genetics center in India.

8 Nov 2012

Washington University, SRI investigators launch Global Metabolomic Initiative

Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of bacteria, yeast, plants, animals and people.

7 Nov 2012

Arisaph’s ARI-3037MO well tolerated in healthy male and female volunteers

Arisaph Pharmaceuticals, Inc. announced today during an oral presentation at the American Heart Association (AHA) meeting in Los Angeles, CA that its niacin analog, ARI-3037MO, was extremely well tolerated in a single-ascending dose (SAD) and a multiple-ascending dose (MAD) trial in healthy male and female volunteers.

7 Nov 2012

New test device allows 'more real-life modeling' of contact lens wear

Modern contact lens materials are prone to drying when exposed to air, which contributes to the buildup of deposits on contact lenses, according to a study - "The Impact of Intermittent Air Exposure on Lipid Deposition", appearing in the November issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

6 Nov 2012

Genkyotex announces positive results from GKT137831 Phase I studies on healthy subjects

Genkyotex, the leading developer of NOX inhibitors to treat oxygen-radical mediated diseases, announced today that Phase I studies have demonstrated excellent safety and tolerability following single and multiple oral doses of GKT137831, the first in class NOX 1 and 4 inhibitor. In addition, GKT137831 demonstrated a favourable pharmacokinetic profile in these subjects.

3 Nov 2012

Mass spectrometry can help visualize how drugs work inside living cells to kill infectious microbes

Weill Cornell Medical College researchers report that mass spectrometry, a tool currently used to detect and measure proteins and lipids, can also now allow biologists to "see" for the first time exactly how drugs work inside living cells to kill infectious microbes.

3 Nov 2012

TransTech Pharma to complete TTP054 Phase 2 trial on type 2 diabetes

TransTech Pharma, Inc., announced today that recruitment of patients for its recently initiated, multi-center Phase 2 clinical trial of TTP054 in type 2 diabetics, is exceeding expectations with initial top line results available in early 2013. The 90-day proof of concept study is being conducted in type 2 diabetics not well controlled with approved oral anti-diabetic agents.

2 Nov 2012

FDA accepts Sunovion’s two LATUDA sNDAs for review

Sunovion Pharmaceuticals Inc. today announced that the U.S. Food and Drug Administration (FDA) has accepted for review two supplemental New Drug Applications (sNDAs) for the use of LATUDA as 1) monotherapy and 2) adjunctive therapy to lithium or valproate, both to treat adult patients with depressive episodes associated with bipolar I disorder (bipolar depression).

31 Oct 2012

Researchers find that children's brains are more affected by inhaled anesthetic

Stony Brook University School of Medicine researchers have found that children's brains are more affected by an inhaled anesthetic than an intravenous anesthetic with increased levels of brain lactate.

29 Oct 2012

TSRI scientists to study structural rules that govern nuclear receptors

A consortium of scientists from both campuses of The Scripps Research Institute (TSRI) has been awarded $2.7 million from the National Institute of General Medical Sciences of the National Institutes of Health to study the structural rules that govern a large superfamily of proteins that help regulate critical functions such as reproduction, development and metabolism.

24 Oct 2012