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Brachytherapy improves overall survival for women with inoperable early stage endometrial cancer

Women who have early stage endometrial cancer and are inoperable tend to live longer if they have been treated with brachytherapy with or without external beam radiation, according to new research to be presented at the 3rd ESTRO Forum in Barcelona, Spain, on Sunday.

27 Apr 2015

ATA guidelines provide recommendations for managing thyroid nodules and thyroid cancer in children

Previous guidelines from the American Thyroid Association for evaluating and managing thyroid nodules and thyroid cancers targeted adults. Recognizing the potential differences in clinical presentation and long-term outcomes, and the potential risks of overly aggressive therapy in pediatric patients with thyroid cancer, an ATA Task Force developed management guidelines for children with thyroid nodules and differentiated thyroid cancer (DTC), which are published in Thyroid, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers and the official journal of the American Thyroid Association.

23 Apr 2015

Data from pacritinib Phase 3 PERSIST-1 trial in patients with myelofibrosis to be highlighted at ASCO

CTI BioPharma Corp. and Baxter International Inc. today announced that data from the randomized Phase 3 PERSIST-1 trial evaluating the investigational agent pacritinib in patients with myelofibrosis will be highlighted in a late-breaking oral presentation at the upcoming American Society of Clinical Oncology 2015 Meeting (May 29-June 2, 2015 in Chicago, Ill).

From Baxter International Inc. 22 Apr 2015

Cantrixil drug granted FDA Orphan Drug Designation for treatment of ovarian cancer

US-Australian drug discovery company, Novogen, today announced that its subsidiary joint venture company with Yale University, CanTx, Inc, has today received notification from the U.S. Food and Drug Administration that its chemotherapy candidate drug, Cantrixil, has been granted Orphan Drug Designation for ovarian cancer.

22 Apr 2015

Study attributes mild cognitive defects in women to post-traumatic stress induced by cancer diagnosis

Breast cancer patients often display mild cognitive defects even before the initiation of chemotherapy. A new study by Ludwig-Maximilians-Universitaet in Munich researchers now attributes the syndrome to post-traumatic stress induced by diagnosis of the disease.

21 Apr 2015

Mayo Clinic heart transplant surgeons present findings from three clinical studies at ISHLT 2015

Heart transplant surgeons from Mayo Clinic are presenting findings from three recent clinical studies involving heart transplant patients. The presentations took place during the 2015 International Society of Heart & Lung Transplant in Nice, France, on April 15-18.

21 Apr 2015

Allele-specific lncRNA regulates cancer metabolism

Long non-coding RNAs (lncRNA) are unusual in that they don't encode proteins like normal RNA. Yet they do play a role in regulating cellular functions and interest cancer researchers.

21 Apr 2015

Insulin signaling pathway has significant influence on the growth of glioblastomas

Drugs that target insulin pathways to slow or stop the growth of brain tumors are going in the right direction but appear to be on the wrong track, according to new research at Rice University.

21 Apr 2015

Pembrolizumab drug halts tumor growth in 76% of patients with pleural mesothelioma

The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

20 Apr 2015

Veracyte launches new genomic test to improve lung cancer diagnosis

Veracyte, Inc., a molecular diagnostic company pioneering the field of molecular cytology, today announced the launch of its Percepta Bronchial Genomic Classifier, a new genomic test to resolve ambiguity in lung cancer diagnosis. The company will soon begin testing patient samples in its CLIA-certified laboratory, with the Percepta test now available to a limited number of institutions around the country.

16 Apr 2015

New research links megalin protein with malignant melanomas

Today it is not possible to predict spreading from malignant melanomas. Melanoma metastases are furthermore extremely difficult to eliminate as traditional treatment such as chemotherapy and radiotherapy is mostly ineffective. Only ten per cent of the patients survive once they reach an advanced stage with distant metastases.

16 Apr 2015

Experts to make roadmap for future research, clinical trials for SCLC patients at IASLC workshop

Small cell lung cancer (SCLC) will be the concentrated focus when 100 global experts in the field meet for a workshop hosted by the International Association for the Study of Lung Cancer on April 22-24, 2015 at Memorial Sloan Kettering Cancer Center in New York City.

15 Apr 2015

New study could hold key to control growth of cancer cells

A new study by researchers at the Technion-Israel Institute of Technology could hold a key to control cancer cell growth and development. In a paper published yesterday in CELL, the team reports on the discovery of two cancer-suppressing proteins.

12 Apr 2015

Two case studies provide potential new avenue for treatment of kidney cancer

UT Southwestern Medical Center Kidney Cancer Program investigators have published what is believed to be the first reported successful use of stereotactic body radiation therapy for an often deadly complication of kidney cancer.

8 Apr 2015

Study suggests possibility of developing personalized treatments for brain cancer

DNA mutations can cause cancer but in some cases, more mutations may mean a better prognosis for patients. A Yale-led comprehensive genomic analysis of more than 700 brain tumors has revealed one such subtype of the most malignant brain tumor, called glioblastoma, or GBM. This subtype possesses thousands of tumor-specific DNA errors or mutations instead of dozens observed in most glioblastoma cases. It is also associated with longer survival.

8 Apr 2015

Study: Key signaling pathway in B-cell lymphoma can be blocked using compounds

Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant type of blood cancer.

7 Apr 2015

Leukemia drug could prevent and control growth of colorectal tumours

Scientists from Nanyang Technological University (NTU Singapore) and Sweden's Karolinska Institutet, one of Europe's largest and most prestigious medical universities, have discovered that an existing chemotherapy drug used to treat leukaemia could prevent and control the growth of colorectal tumours.

3 Apr 2015

Malignant News and Research

Brachytherapy improves overall survival for women with inoperable early stage endometrial cancer

ATA guidelines provide recommendations for managing thyroid nodules and thyroid cancer in children

Data from pacritinib Phase 3 PERSIST-1 trial in patients with myelofibrosis to be highlighted at ASCO

Cantrixil drug granted FDA Orphan Drug Designation for treatment of ovarian cancer

Study attributes mild cognitive defects in women to post-traumatic stress induced by cancer diagnosis

Mayo Clinic heart transplant surgeons present findings from three clinical studies at ISHLT 2015

Allele-specific lncRNA regulates cancer metabolism

Insulin signaling pathway has significant influence on the growth of glioblastomas

Pembrolizumab drug halts tumor growth in 76% of patients with pleural mesothelioma

Veracyte launches new genomic test to improve lung cancer diagnosis

New research links megalin protein with malignant melanomas

Experts to make roadmap for future research, clinical trials for SCLC patients at IASLC workshop

New study could hold key to control growth of cancer cells

Two case studies provide potential new avenue for treatment of kidney cancer

Study suggests possibility of developing personalized treatments for brain cancer

Study: Key signaling pathway in B-cell lymphoma can be blocked using compounds

Leukemia drug could prevent and control growth of colorectal tumours

Research may point to new paradigms in diagnosis, treatment of aggressive cancers

TSRI scientists uncover unique mechanism of natural product with antimicrobial, anti-cancer effects

New study sheds light on natural small molecule with antimicrobial effects

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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