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Epigenomic alterations play key role in triggering obesity-induced diabetes

Obesity is a risk factor for developing type 2 diabetes, yet not all obese humans develop the disease. In a new study, researchers from the Karolinska Institutet in Sweden and from the Institute of Health and Medical Research in France have identified epigenomic alterations that are associated with inflammation and type 2 diabetes

7 Jun 2016

Genes of healthy leanness could lead to new approach to treating obesity-related diabetes

People with type 2 diabetes could be helped by the discovery of a gene linked to leanness.

7 Jun 2016

Northwestern Medicine scientists link TMEM230 gene mutations to Parkinson's disease development

Northwestern Medicine scientists have discovered a new cause of Parkinson's disease -- mutations in a gene called TMEM230. This appears to be the third gene definitively linked to confirmed cases of the common movement disorder.

7 Jun 2016

$One-third of osteoporotic women taking oral bisphosphonates have elevated risk for bone fracture$

One-third of osteoporotic women taking oral bisphosphonates have elevated risk for bone fracture

More than 53 million Americans age 50 and older, primarily women, have osteoporosis or are at high risk for the condition due to low bone density. A recent study of oral bisphosphonates, the most commonly prescribed osteoporosis treatment, found that approximately a third of women prescribed these drugs continue to be at elevated risk for bone fracture, an outcome that may have several origins.

7 Jun 2016

Higher blood levels of methotrexate impair executive functioning in long-term pediatric ALL survivors

Research from St. Jude Children's Research Hospital suggests that pediatric leukemia patients exposed to higher concentrations of the chemotherapy drug methotrexate are more likely to struggle with mental flexibility, organization and related skills as long-term survivors.

7 Jun 2016

Zika virus directly infects brain progenitor cells in newborns to cause neurological problems

The mosquito-borne Zika virus linked to microcephaly and other neurological problems in newborns of affected mothers directly infects the brain progenitor cells destined to become neurons, UT Southwestern Medical Center researchers report in a study published online today in Cell Reports.

6 Jun 2016

Scientists find tiny organisms in upper female reproductive tract once thought to be sterile

They're inside our gut, on the skin, and in the mouth. Thousands of different types of micro-organisms live in and on the body, playing helpful roles in digestion or in aiding the body's natural defense system.

6 Jun 2016

New study finds alternative approaches to target proteins sustaining cancer, Alzheimer's disease

Drugs to treat cancer and Alzheimer's disease usually target the active sites of specific protein molecules sustaining the disease. Traditional drug design views proteins as rigid 3-D objects with active sites consisting of surface-accessible "pockets" with a specific, well-defined structure.

6 Jun 2016

Intellectually challenging job linked to better memory, cognitive functioning

Working in a more intellectually challenging job is associated with better memory and other aspects of cognitive functioning, reports a study in the June Journal of Occupational and Environmental Medicine, official publication of the American College of Occupational and Environmental Medicine.

6 Jun 2016

Study finds link between stress hormone and stage of schizophrenia

JCU Associate Professor Zoltan Sarnyai said it was the first meta-analysis study to compare the level of cortisol in a waking patient's body with the stage of schizophrenia they are suffering.

6 Jun 2016

Study: Majority of food, beverage products endorsed by music celebrities are unhealthy

Recording artists are frequently the face of commercial products—and children and adolescents are frequently their target audience. Now, a new study by researchers at NYU Langone Medical Center finds that the vast majority of the food and beverage products marketed by some of the most popular music stars are unhealthy.

6 Jun 2016

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

A significant proportion of lung cancer patients also have autoimmune disease, which may make them unsuitable for increasingly popular immunotherapy treatments, a team of researchers at UT Southwestern Medical Center's Harold C. Simmons Comprehensive Cancer Center has found.

6 Jun 2016

Neutral atherosclerosis trial highlights effectiveness of optimal medical therapy

Salsalate has no greater effect than placebo on the progression of coronary artery plaque, show the findings of the randomised TINSAL-CVD trial.

3 Jun 2016

Researchers detect vascular matrix stiffening during early stages of pulmonary hypertension

Pulmonary hypertension is an abnormal elevation of pressure in the pulmonary circulation that results in stress on the heart and remodeling of blood vessels in the lung.

3 Jun 2016

Scientists discover master dimmer switches that control activity of immune cells

A person's genetic makeup plays a role in autoimmune diseases such as multiple sclerosis that develop when the body is attacked by its own immune system. But little is known about how immune cells are pushed into overdrive.

3 Jun 2016

Common genetic variant in HO-1 gene linked to AKI risk following cardiac surgery

Testing for a common genetic variant may help reveal which patients face an increased risk of developing kidney damage following heart surgery. The findings, which come from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology, may help investigators develop therapeutic strategies to mitigate this damage.

3 Jun 2016

New research highlights value of exercise for humans looking to keep their brains fit

The relentless desire by mice to run on cage "exercise" wheels has helped explain at a molecular level how exercise benefits a mammal's brain.

2 Jun 2016

$Sostdc1 gene may play vital role in fracture healing process$

Sostdc1 gene may play vital role in fracture healing process

New identification of a gene involved in the fracture healing process could lead to the development of new therapeutic treatments for difficult-to-heal injuries.

2 Jun 2016

New mouse model offers more insight into development of ASD in humans

A new mouse model, developed by researchers at the University of Wisconsin-Madison, is the first to show that when more of a specific biological molecule moves between different parts of nerve cells in the mouse brain, it can lead to behaviors that resembles some aspects of autism spectrum disorder (ASD) in humans.

2 Jun 2016

Study finds beer consumption may protect against Aβ aggregation in the brain

While most people will agree that excessive consumption of alcohol can have a detrimental effect on the brain, there is less agreement regarding the effects of light or moderate drinking.

2 Jun 2016

X linked News and Research

Epigenomic alterations play key role in triggering obesity-induced diabetes

Genes of healthy leanness could lead to new approach to treating obesity-related diabetes

Northwestern Medicine scientists link TMEM230 gene mutations to Parkinson's disease development

One-third of osteoporotic women taking oral bisphosphonates have elevated risk for bone fracture

Higher blood levels of methotrexate impair executive functioning in long-term pediatric ALL survivors

Zika virus directly infects brain progenitor cells in newborns to cause neurological problems

Scientists find tiny organisms in upper female reproductive tract once thought to be sterile

New study finds alternative approaches to target proteins sustaining cancer, Alzheimer's disease

Intellectually challenging job linked to better memory, cognitive functioning

Study finds link between stress hormone and stage of schizophrenia

Study: Majority of food, beverage products endorsed by music celebrities are unhealthy

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

Neutral atherosclerosis trial highlights effectiveness of optimal medical therapy

Researchers detect vascular matrix stiffening during early stages of pulmonary hypertension

Scientists discover master dimmer switches that control activity of immune cells

Common genetic variant in HO-1 gene linked to AKI risk following cardiac surgery

New research highlights value of exercise for humans looking to keep their brains fit

Sostdc1 gene may play vital role in fracture healing process

New mouse model offers more insight into development of ASD in humans

Study finds beer consumption may protect against Aβ aggregation in the brain

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