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Researchers discover novel way to enhance, restore cancer suppressor activity in B-ALL

Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B-cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease. The finding could pave the way for a new class of drugs for this and other forms of leukemia.

15 Dec 2015

Experimental drugs that modify cell metabolism also halt tumor growth

Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study led by researchers at NYU Langone Medical Center, its Laura and Isaac Perlmutter Cancer Center and Massachusetts General Hospital.

15 Dec 2015

Using antidepressants during pregnancy greatly increases autism risk

Using antidepressants during pregnancy greatly increases the risk of autism, Professor Anick Bérard of the University of Montreal and its affiliated CHU Sainte-Justine children's hospital revealed today. Prof. Bérard, an internationally renowned expert in the fields of pharmaceutical safety during pregnancy, came to her conclusions after reviewing data covering 145,456 pregnancies.

15 Dec 2015

New study describes a way to identify complex type of mutation in cancer genomes

New research shows that current approaches to genome analysis systematically miss detecting a certain type of complex mutation in cancer patients' tumors. Further, a significant percentage of these complex mutations are found in well-known cancer genes that could be targeted by existing drugs, potentially expanding the number of cancer patients who may benefit.

15 Dec 2015

Researchers discover first broad spectrum drug that can potently kill aging cells in culture

Researchers from the University of Arkansas for Medical Sciences and other institutions are reporting the discovery of the first broad spectrum drug that can potently kill senescent (or aging) cells in culture and effectively clear the cells in animals by specifically targeting a pathway that is critical for the survival of senescent cells.

15 Dec 2015

Global Health Impact Index can measure actual impact of drugs worldwide

Billions of dollars have been spent on developing drugs and supplying them around the world, but which companies' drugs are actually making an impact? The Global Health Impact Index, headed by Binghamton University Associate Professor Nicole Hassoun and highlighted in a new article published Friday in PLOS ONE, addresses this issue by ranking pharmaceutical companies based on their drugs' impact on global health.

15 Dec 2015

Antibiotic resistance may help find drugs to combat amyloid formation

Amyloid diseases such as Parkinson's, Alzheimer's and type-2 diabetes pose a particular problem for drug designers because they do not present a clear target structure to aim at.

15 Dec 2015

Human body clock study paves way for drug treatment of osteoarthritis

A University of Manchester biologist has for the first time established that the painful and debilitating symptoms endured by osteoarthritis sufferers are intrinsically linked to the human body clock.

15 Dec 2015

SLU scientist awarded new $2.2 million NIH grant to develop cure for hepatitis B

With proof-of-principle in his pocket and a new $2.2 million grant from the National Institutes of Health, SLU scientist John Tavis, Ph.D., will take his 25 year mission to finally develop a cure for the hepatitis B virus into the next phase.

15 Dec 2015

ESSA reports net loss of $11.5 million for year ended September 30, 2015

ESSA Pharma Inc. today reported financial results for the year ended September 30, 2015. Amounts, unless specified otherwise, are expressed in Canadian dollars and in accordance with International Financial Reporting Standards ("IFRS").

15 Dec 2015

Experts call for radical action to assure health for entire India

A paper published in The Lancet today calls for a radical transformation in the architecture of India’s healthcare delivery system, if the country is to achieve the government’s vision of assuring health for all.

15 Dec 2015

Study: Brain cell death may trigger multiple sclerosis

Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medicine. The death of these cells initiates an autoimmune response against myelin, the main characteristic of the disease, which leads to MS-like symptoms in mice.

14 Dec 2015

Study offers insight into how female Viagra affects the brain

As the drug touted as "the female Viagra" comes to market, researchers at the University of Wisconsin-Madison are learning more about how the drug, called flibanserin, affects the brain.

13 Dec 2015

Nutritionist offers myriad methods to help people eat during cancer treatment

Ernestine Trujillo, MS, RD, LD, plays an important role in helping people through their cancer treatment: she helps them to eat. Eating keeps their strength up so that they can get through treatment. But eating during cancer treatment isn't always easy. Trujillo, a Senior Clinical Nutritionist at the University of New Mexico Comprehensive Cancer Center, offers myriad methods to help people get the nutrition they need.

13 Dec 2015

Innovative Phase II trial evaluates effectiveness of diabetes medication for lymphoma

Cancer, it could be said, grows like a weed: rapidly, invasively, and with devastating impact on the place it infests. Also like a weed, cancer can't grow on its own — it needs nourishment, which it drains from the human body, just as weeds take nutrients in the soil away from other plants.

13 Dec 2015

Perceived stress increases likelihood of amnestic mild cognitive impairment in older people

Feeling stressed out increases the likelihood that elderly people will develop mild cognitive impairment—often a prelude to full-blown Alzheimer's disease. In a new study, scientists at Albert Einstein College of Medicine and Montefiore Health System found that highly stressed participants were more than twice as likely to become impaired than those who were not.

13 Dec 2015

Paying close attention to results of simple blood test can help predict risk of kidney failure, death

Kidney disease in the United States is both common and under-diagnosed, but two new studies led by Johns Hopkins Bloomberg School of Public Health researchers suggest that paying close attention to results of a simple blood test can help predict the likelihood that patients are headed for kidney failure or death.

13 Dec 2015

Earlier intervention can lead to better recovery in underweight children with multiple household risk factors

Young children who are underweight experienced greater weight recovery the earlier an intervention was started, and the recovery was more significant in children with multiple household risk factors, according to a study published this week in The Journal of Pediatrics.

12 Dec 2015

New MSK-led studies on liquid biopsy presented at San Antonio Breast Cancer Symposium

Information gleaned from a liquid biopsy may help predict how individual women with advanced breast cancer will respond to certain therapies as well as reveal genetic mutations that can impact prognosis, according to two new studies led by Memorial Sloan Kettering Cancer Center Physician-in-Chief José Baselga and physician-scientist Sarat Chandarlapaty.

12 Dec 2015

Larger crystals of bacteriorhodopsin protein grow by consuming smaller crystals around them

A group of biophysicists from Moscow Institute of Physics and Technology and their international colleagues have studied the crystallization of molecules of the membrane protein bacteriorhodopsin. The scientists have demonstrated that the larger crystals of the protein grow by "consuming" smaller crystals around them and creating "depletion zone" around themselves.

12 Dec 2015

Drugs News and Research

Researchers discover novel way to enhance, restore cancer suppressor activity in B-ALL

Experimental drugs that modify cell metabolism also halt tumor growth

Using antidepressants during pregnancy greatly increases autism risk

New study describes a way to identify complex type of mutation in cancer genomes

Researchers discover first broad spectrum drug that can potently kill aging cells in culture

Global Health Impact Index can measure actual impact of drugs worldwide

Antibiotic resistance may help find drugs to combat amyloid formation

Human body clock study paves way for drug treatment of osteoarthritis

SLU scientist awarded new $2.2 million NIH grant to develop cure for hepatitis B

ESSA reports net loss of $11.5 million for year ended September 30, 2015

Experts call for radical action to assure health for entire India

Study: Brain cell death may trigger multiple sclerosis

Study offers insight into how female Viagra affects the brain

Nutritionist offers myriad methods to help people eat during cancer treatment

Innovative Phase II trial evaluates effectiveness of diabetes medication for lymphoma

Perceived stress increases likelihood of amnestic mild cognitive impairment in older people

Paying close attention to results of simple blood test can help predict risk of kidney failure, death

Earlier intervention can lead to better recovery in underweight children with multiple household risk factors

New MSK-led studies on liquid biopsy presented at San Antonio Breast Cancer Symposium

Larger crystals of bacteriorhodopsin protein grow by consuming smaller crystals around them

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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