Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

AP-1 proteins modulate fat accumulation in liver, say researchers

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease.

8 Jan 2014

Study identifies strategy to help women climb the academic ladder

More women are choosing science careers, yet women are notoriously underrepresented in senior academic positions—often because they abandon their careers due to pessimism about advancement. New research suggests that putting more women in decision-making roles on the teams that organize symposia could offer a simple, effective step forward.

7 Jan 2014

Support from lactation consultant improves chances of breastfeeding

In two separate clinical trials, researchers at Albert Einstein College of Medicine of Yeshiva University have found that periodic meetings with a lactation consultant encourages women traditionally resistant to breastfeeding to do so, at least for a few months-long enough for mother and child to gain health benefits. The results of the trials were published online today in American Journal of Public Health.

28 Dec 2013

SLU professor offers 6 tips to relieve stress

Have you made a New Year's resolution yet? Consider this - as we inch closer to the New Year, William Manard, M.D., assistant professor in the department of family and community medicine at Saint Louis University suggests making a broad lifestyle change by better managing your emotional health.

27 Dec 2013

Periodic meetings with lactation consultant improves chances of breastfeeding

In two separate clinical trials, researchers at Albert Einstein College of Medicine of Yeshiva University have found that periodic meetings with a lactation consultant encourages women traditionally resistant to breastfeeding to do so, at least for a few months—long enough for mother and child to gain health benefits.

20 Dec 2013

Study supports mounting evidence that inflammation may be the cause of chronic rhinosinusitis

Saint Louis University researchers have analyzed the microbiomes of people with chronic rhinosinusitis and healthy volunteers and found evidence that some chronic sinus issues may be the result of inflammation triggered by an immune response to otherwise harmless microorganisms in the sinus membranes.

20 Dec 2013

Researchers reveal how metabolic system breaks down in obesity

Researchers at University of Michigan have illuminated an aspect of how the metabolic system breaks down in obesity. The findings provide additional evidence that a drug entering clinical trials at the university could reverse obesity, Type 2 diabetes and fatty liver disease in humans.

20 Dec 2013

UT Southwestern receives $10M grant to find effective treatments for alcoholic hepatitis

UT Southwestern Medical Center has launched the local arm of a national, multicenter study aimed at finding more effective treatments for alcoholic hepatitis, a disease of the liver that often leads to cirrhosis and death in severe cases.

19 Dec 2013

Alnylam initiates Phase II study with ALN-TTRsc for treatment of ATTR

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has initiated a pilot Phase II study with ALN-TTRsc, a subcutaneously delivered RNAi therapeutic targeting the transthyretin gene in development for the treatment of TTR-mediated amyloidosis.

17 Dec 2013

Scientists continue work to end chemotherapy pain

With this year's $600,000 grant from the Leukemia & Lymphoma Society and $1.5 million grant from the NIH, a Saint Louis University investigator is continuing her work to end chemotherapy pain. Noted pain researcher Daniela Salvemini, Ph.D., is using the funding to capitalize on her recent finding published in Pain, a breakthrough that helps scientists understand a molecular pathway by which pain occurs with certain anti-cancer drugs.

17 Dec 2013

Dermatologist offers 5 grooming essentials for men to make skin healthy and glow

If you're short on holiday gift ideas for men this season, consider a grooming product. Contrary to popular belief, a growing number of men are requesting recommendations for skincare products, says Natalie Semchyshyn, M.D., assistant professor of dermatology at Saint Louis University.

16 Dec 2013

Women are more susceptible to damaging effects of alcohol than men

Women are more susceptible to the damaging effects of alcohol than men because they are generally smaller in stature and have less body water than men, according to a leading Houston hepatologist.

16 Dec 2013

Cellular Biomedicine Group completes TC-DC Phase I clinical trial for hepatocellular carcinoma

Cellular Biomedicine Group, Inc., a biomedicine firm engaged in the development of new treatments for degenerative and cancerous diseases, is pleased to announce that it has treated the final patient of its Phase I clinical trial which evaluates the safety and preliminary efficacy of TC-DC (Tumor Stem Cell Specific Dendritic Cell) therapy for hepatocellular carcinoma, the most common type of liver cancer.

16 Dec 2013

Texas Children's Heart Center opens Center for Preventive Cardiology

Texas Children's Heart Center is proud to announce the opening of the Center for Preventive Cardiology, which is designed to medically manage the risk factors of acquired heart disease in children. The center is the only one of its kind in Texas that offers multidisciplinary, specialized care for children with these risk factors or who have a strong family history of cardiac disease, elevated cholesterol, high blood pressure or the diagnosis of Kawasaki disease.

13 Dec 2013

Medivir initiates phase IIa trial to evaluate efficacy of simeprevir combination therapy in HCV-infected patients

Medivir AB (STO:MVIR-B) (OMX: MVIR), announces the initiation of a phase IIa trial in chronic genotype 1 hepatitis C infected patients to evaluate the efficacy, safety and tolerability of a 12-week combination therapy of simeprevir, TMC647055 and JNJ56914845, a NS5A replication complex inhibitor.

12 Dec 2013

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

AstraZeneca and Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration's (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) recommends the investigational medicine metreleptin for the treatment of pediatric and adult patients with generalized lipodystrophy (LD).

12 Dec 2013

Celgene subsidiary presents REVLIMID study results on lymphoma at ASH annual meeting

Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation (NASDAQ:CELG) today announced that results from two studies of REVLIMID (lenalidomide) combinations in patients with diffuse large B-cell lymphoma (DLBCL) were presented at the American Society of Hematology annual meeting in New Orleans, La.

11 Dec 2013

Study looks at brain imaging data in veterans who suffered combat-related head injuries

In preliminary findings, Saint Louis University researchers report that veterans who suffered blast injuries have changes in brain tissue that are still apparent in images years after the blast. The data, presented at the annual meeting of the Radiological Society of North America, represents a small but intriguing look at brain imaging in those who suffered combat-related head injuries.

11 Dec 2013

Alnylam presents new pre-clinical data with ALN-AT3 for treatment of hemophilia and RBD

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data with ALN-AT3, a subcutaneously administered RNAi therapeutic targeting antithrombin (AT) for the treatment of hemophilia and rare bleeding disorders (RBD), at the 55th Annual Meeting of the American Society of Hematology (ASH) held December 7 - 10, 2013 in New Orleans.

10 Dec 2013

Revised Clinical Practice Guidelines on management of HCV published by EASL

The European Association for the Study of the Liver today publishes their revised Clinical Practice Guidelines (CPGs) on the management of hepatitis C virus infection. The EASL guidelines, which supersede the previous version published in 2011, are designed to help physicians and other healthcare providers optimise their management of patients with acute and chronic HCV.

9 Dec 2013

Liver Disease News and Research

Further Reading

AP-1 proteins modulate fat accumulation in liver, say researchers

Study identifies strategy to help women climb the academic ladder

Support from lactation consultant improves chances of breastfeeding

SLU professor offers 6 tips to relieve stress

Periodic meetings with lactation consultant improves chances of breastfeeding

Study supports mounting evidence that inflammation may be the cause of chronic rhinosinusitis

Researchers reveal how metabolic system breaks down in obesity

UT Southwestern receives $10M grant to find effective treatments for alcoholic hepatitis

Alnylam initiates Phase II study with ALN-TTRsc for treatment of ATTR

Scientists continue work to end chemotherapy pain

Dermatologist offers 5 grooming essentials for men to make skin healthy and glow

Women are more susceptible to damaging effects of alcohol than men

Cellular Biomedicine Group completes TC-DC Phase I clinical trial for hepatocellular carcinoma

Texas Children's Heart Center opens Center for Preventive Cardiology

Medivir initiates phase IIa trial to evaluate efficacy of simeprevir combination therapy in HCV-infected patients

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

Celgene subsidiary presents REVLIMID study results on lymphoma at ASH annual meeting

Study looks at brain imaging data in veterans who suffered combat-related head injuries

Alnylam presents new pre-clinical data with ALN-AT3 for treatment of hemophilia and RBD

Revised Clinical Practice Guidelines on management of HCV published by EASL

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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