Malignant News and Research

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Patients who undergo chemo before breast cancer operation more likely to opt for lumpectomy

Patients with larger malignant tumors of the breast who undergo chemotherapy before a breast cancer operation are more likely to opt for a breast-preserving procedure and forgo a mastectomy (surgical removal of the breast), according to a new study published online as an "article in press" in the Journal of the American College of Surgeons.

28 Feb 2015

New cancer drug enters phase I clinical trials in humans

A new drug that prompts cancer cells to self-destruct while sparing healthy cells is now entering phase I clinical trials in humans. The drug, called PAC-1, first showed promise in the treatment of pet dogs with spontaneously occurring cancers, and is still in clinical trials in dogs with osteosarcoma.

27 Feb 2015

Scientists find new links between inflammation and tissue regeneration

Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair - a process that is generally understood but remains mysterious in its particulars.

26 Feb 2015

New TAU study may offer hope to people diagnosed with Glioblastoma multiforme

There are no effective available treatments for sufferers of Glioblastoma multiforme (GBM), the most aggressive and devastating form of brain tumor. The disease, always fatal, has a survival rate of only 6-18 months.

25 Feb 2015

New NCCN Guidelines for treating Acute Lymphoblastic Leukemia

According to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Acute Lymphoblastic Leukemia (ALL), the treatment approach to ALL is one of the most complex and intensive programs in cancer therapy.

24 Feb 2015

New HPV vaccine has potential to prevent 90% of conditions triggered by HPV

A new vaccine against HPV infections has the potential to prevent 90 per cent of all of the conditions triggered by the human papillomavirus. These are the findings of a randomised, controlled, international study involving a new, 9-component vaccine against HPV used on more than 14,000 young women aged between 16 and 26 years.

23 Feb 2015

Proximity Ligation Assay helps detect effectiveness of cancer vaccines

Cancer vaccines are designed to turn the body's own immune system specifically against tumor cells. Particularly promising are vaccines that are directed against so-called neoantigens: These are proteins that have undergone a genetic mutation in tumor cells and, therefore, differ from their counterparts in healthy cells.

20 Feb 2015

Researchers show how gene mutations cause common forms of cartilage tumors

Duke Medicine researchers have shown how gene mutations may cause common forms of cartilage tumors. In a study published in the Feb. 16, 2015, issue of the Proceedings of the National Academy of Sciences, Duke researchers and their colleagues revealed that mutations in the isocitrate dehydrogenase (IDH) gene contribute to the formation of benign tumors in cartilage that can be a precursor to malignancies.

17 Feb 2015

ASU to host inaugural meeting for brand new scientific society in Tempe, Arizona

Arizona State University will host a premiere opportunity to engage and mingle with luminaries in the burgeoning field of evolutionary medicine, a new interdisciplinary approach that is becoming an essential perspective in our view of disease, today's medical practice and the worldwide impact on public health as it hosts the Inaugural International Society for Evolution, Medicine & Public Health Meeting, March 19-21, 2015 in Tempe, Arizona.

17 Feb 2015

Changes in moles and skin cancer: an interview with Dr Anjali Mahto, Consultant Dermatologist & British Skin Foundation Spokesperson

Melanoma is the 5th most common cancer in the UK and its incidence is continuing to increase since the mid-1970s. Cancer Research UK reports that its rates have increased more rapidly than any of the current ten most common cancers in males and females. Whilst some of this may be attributed to better surveillance and earlier detection, the real problem lies with sun-seeking behaviour and exposure to ultraviolet (UV) radiation.

16 Feb 2015

Researcher uses Gene Rank technique to capture, describe gene connectivity

Using the technique known as "Gene Rank" (GR), Dartmouth's Norris Cotton Cancer Center investigator Eugene Demidenko, PhD, captured and described a new characterization of gene connectivity in "Microarray Enriched Gene Rank," published in BioData Mining. The effective computer algorithm can be used to compare tissues across or within organisms at great speed with a simple laptop computer.

15 Feb 2015

Novel image-analysis technique improves breast cancer detection and diagnosis

Researchers at the University of Oklahoma have developed an image-analysis technique that is designed to improve breast cancer detection and diagnosis.

13 Feb 2015

Study finds higher levels of malignant mesothelioma cases in southern Nevada

Malignant mesothelioma has been found at higher than expected levels in women and in individuals younger than 55 years old in the southern Nevada counties of Clark and Nye, likewise in the same region carcinogenic mineral fibers including actinolite asbestos, erionite, winchite, magnesioriebeckite and richterite were discovered.

11 Feb 2015

Oncolytics Biotech submits Orphan Drug Designation for high grade gliomas in pediatric patients

Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY) today announced that it has submitted an application for Orphan Drug Designation to the U.S. Food and Drug Administration ("FDA") for REOLYSIN® for the treatment of high grade gliomas (HGG) in pediatric patients.

9 Feb 2015

New findings could pave way to develop drug therapies for necrosis-related diseases

Strokes, heart attacks and traumatic brain injuries are separate diseases with certain shared pathologies that achieve a common end - cell death and human injury due to hypoxia, or lack of oxygen.

9 Feb 2015

Salicylates drugs reduce proliferation, viability of cultured vestibular schwannoma cells

Researchers from Massachusetts Eye and Ear and the Harvard Medical School/ Massachusetts Institute of Technology's Program in Speech and Hearing Bioscience and Technology have demonstrated that salicylates, a class of non-steroidal inflammatory drugs (NSAIDs), reduced the proliferation and viability of cultured vestibular schwannoma cells that cause a sometimes lethal intracranial tumor that typically causes hearing loss and tinnitus.

9 Feb 2015

Chinese researchers achieve major breakthrough in nano-carrier drugs for pancreatic cancer

At the "Symposium on the Application of Genetic Testing in Individualized Diagnosis and Treatment of Tumor" recently held in Tianjin, the research team led by Professor Hao Jihui of the Pancreas Oncology Department of Tianjin Medical University Cancer Hospital announced that they had achieved a major breakthrough in the field of nano-carrier drugs for pancreatic cancer.

6 Feb 2015

Newly found protein in naked mole rat helps ward off cancer

A protein newly found in the naked mole rat may help explain its unique ability to ward off cancer.

5 Feb 2015

Scientists investigate how T cells in colorectal tumors actively fight cancer

In recent years, a standard follow-up to colorectal cancer surgery has been to analyze the tumor tissue for the presence of immune cells. Finding high quantities of cytotoxic T cells, or "killer cells", means that there is a good chance that the disease will take a favorable course and that the risk of metastasis is comparatively low.

5 Feb 2015

Novel EPR oximetry technique may help clinicians directly measure oxygen in cancer, stroke patients

A novel Electron Paramagnetic Resonance (EPR) oximetry technique will help clinicians directly measure oxygen and schedule treatments at times of high oxygen levels in cancer and stroke patients to improve outcomes, The EPR team at Dartmouth's Geisel School of Medicine has found.

5 Feb 2015

Malignant News and Research

Patients who undergo chemo before breast cancer operation more likely to opt for lumpectomy

New cancer drug enters phase I clinical trials in humans

Scientists find new links between inflammation and tissue regeneration

New TAU study may offer hope to people diagnosed with Glioblastoma multiforme

New NCCN Guidelines for treating Acute Lymphoblastic Leukemia

New HPV vaccine has potential to prevent 90% of conditions triggered by HPV

Proximity Ligation Assay helps detect effectiveness of cancer vaccines

Researchers show how gene mutations cause common forms of cartilage tumors

ASU to host inaugural meeting for brand new scientific society in Tempe, Arizona

Changes in moles and skin cancer: an interview with Dr Anjali Mahto, Consultant Dermatologist & British Skin Foundation Spokesperson

Researcher uses Gene Rank technique to capture, describe gene connectivity

Novel image-analysis technique improves breast cancer detection and diagnosis

Study finds higher levels of malignant mesothelioma cases in southern Nevada

Oncolytics Biotech submits Orphan Drug Designation for high grade gliomas in pediatric patients

New findings could pave way to develop drug therapies for necrosis-related diseases

Salicylates drugs reduce proliferation, viability of cultured vestibular schwannoma cells

Chinese researchers achieve major breakthrough in nano-carrier drugs for pancreatic cancer

Newly found protein in naked mole rat helps ward off cancer

Scientists investigate how T cells in colorectal tumors actively fight cancer

Novel EPR oximetry technique may help clinicians directly measure oxygen in cancer, stroke patients

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