Mouse Model News and Research

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Researchers discover biochemical agent responsible for blood pressure drop in sepsis

A study conducted by an international group of researchers has overturned the understanding of life-threatening inflammatory diseases such as sepsis, pointing to a biochemical agent that may be involved in the rapid decline in blood pressure that occurs in the advanced stage of sepsis and usually causes the patient's death. This discovery could pave the way for novel therapeutic approaches.

14 May 2019

Microbes in maternal intestine may contribute to metabolic changes during pregnancy

New research in The Journal of Physiology has found, using a mouse model, that microbes in the maternal intestine may contribute to impairment of the gut barrier during pregnancy.

13 May 2019

New findings could facilitate the development of hepatitis C mouse model

Small differences in a liver cell protein have significant impacts on hepatitis C virus replication in mice and humans, findings that could facilitate the development of a mouse model of the infection. The report, led by researchers at Princeton University, was published today in the journal eLife.

12 May 2019

New computational framework reveals impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice.

10 May 2019

Study: Under-connectivity is the underlying cause of brain disorders

Under-connectivity, or too few connections in the brain, is the underlying cause of brain disorders like autism and schizophrenia, according to a recent study from investigators at the George Washington University Institute for Neuroscience.

10 May 2019

Penn study reveals link between mitochondrial damage and osteoporosis

Some risk factors for osteoporosis such as being older and female or having a family history of the condition cannot be avoided. But others can, like smoking cigarettes, consuming alcohol, taking certain medications, or being exposed to environmental pollutants.

9 May 2019

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

Skin-related stem cells could be used to regenerate vital part of the nervous system

Neurodegenerative diseases like multiple sclerosis affect millions of people worldwide and occur when parts of the nervous system lose function over time.

7 May 2019

Increasing early beta-cell proliferation could halt development of type 1 diabetes

Many in-development cures for type 1 diabetes have understandably focused on tackling the autoimmune aspect of the disease before figuring out a way to replace the destroyed beta cells. But what if focusing on the beta cells first could prevent their destruction altogether?

7 May 2019

Comprehensive brain map reveals ‘hidden’ microglia that may be involved in neurodegenerative diseases

Our brains do not only contain neurons, but also a variety of immune cells that play an important role for its functioning.

6 May 2019

$150,000 grant will support research on spinal muscular atrophy

EL PASO, Texas-Cure SMA recently awarded a $150,000 research grant to Laxman Gangwani, Ph.D., associate professor of Molecular and Translational Medicine, Center of Emphasis in Neurosciences, at TTUHSC El Paso's Paul L. Foster School of Medicine.

2 May 2019

Protein supplements containing BCAA may have ‘detrimental effects’ on health and lifespan

New research suggests that BCAAs in the form of pre-mixed protein powders, shakes and supplements may do more harm to health than good.

1 May 2019

Prior radioprotection via EGLN inhibitor improves survival in mouse model of pancreatic cancer

Administration of the EGLN inhibitor FG-4592 prior to ablative radiotherapy provided protection against fatal gastrointestinal bleeding and improved survival in a mouse model of unresectable pancreatic cancer.

30 Apr 2019

Sleep problems in autism may be linked to gene mutation

Up to 80 percent of children with autism spectrum disorder experience sleep problems.

29 Apr 2019

Scientists discover trigger region for absence epileptic seizures

Scientists have discovered a neurological origin for absence seizures--a type of seizure characterized by very short periods of lost consciousness in which people appear to stare blankly at nothing.

25 Apr 2019

Myelination deficits cause abnormal hypersocial behavior associated with Williams syndrome

A new Tel Aviv University study finds that gene deletion or deficiency in neurons is responsible for the abnormal hypersocial behavior associated with Williams syndrome, a rare disorder affecting 1 in 10,000 people around the world.

24 Apr 2019

Three-antibiotic cocktail eradicates 'persister' Lyme bacteria in mouse model

A new study from researchers at the Johns Hopkins Bloomberg School of Public Health found that a slow-growing variant form of Lyme bacteria caused severe symptoms in a mouse model.

24 Apr 2019

UVA researchers shed light on why C. difficile infections are so dangerous

A new discovery about dangerous C. difficile diarrhea has identified a new way that the bacteria – and possibly others like it – cause severe disease.

23 Apr 2019

MIT scientists reverse some behavioral symptoms of rare neurodevelopmental disorder

Williams Syndrome, a rare neurodevelopmental disorder that affects about one in 10,000 babies born in the United States, produces a range of symptoms including cognitive impairments, cardiovascular problems, and extreme friendliness, or hypersociability.

22 Apr 2019

Scientific breakthrough provides new hope for people living with multiple sclerosis

A scientific breakthrough provides new hope for millions of people living with multiple sclerosis. Researchers at Oregon Health & Science University have developed a compound that stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord.

19 Apr 2019