Malignant News and Research

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Johns Hopkins researchers successfully deliver new nanoparticle gene therapy to treat glioma in rats

Despite improvements in the past few decades with surgery, chemotherapy and radiation therapy, a predictably curative treatment for glioma does not yet exist. New insights into specific gene mutations that arise in this often deadly form of brain cancer have pointed to the potential of gene therapy, but it's very difficult to effectively deliver toxic or missing genes to cancer cells in the brain.

5 Feb 2015

Genomics of papillary thyroid carcinoma (PTC): an interview with Professor Thomas J. Giordano

There are two types of thyroid cells and therefore there are two broad types of thyroid cancer. Medullary carcinoma is derived from parafollicular or C cells, whereas follicular cells give rise to several types of thyroid cancers.

4 Feb 2015

New study sheds light on syndrome linked to aggressive pediatric cancer

A new study involving researchers at The University of Nottingham has revealed how children with an aggressive cancer predisposition syndrome experience a never before seen flood of mutations in their disease in just six months.

4 Feb 2015

Researchers develop optimised PSA screening programme for prostate cancer

As an indicator of prostate cancer, the PSA test is regarded in urology as highly controversial since it is not always unequivocal. A team of researchers from the Comprehensive Cancer Center at the MedUni Vienna and Vienna General Hospital has now developed a programme that compensates the shortfalls of PSA screening with methods from personalised medicine. As a result, prostate cancer screening is able to reach a new level of quality.

4 Feb 2015

Oncology experts study use of fertility-sparing cancer treatments

While families around the world delay childbearing to later in life, cancer diagnoses are affecting people ever earlier in life. When these lifestyle trends collide, we see an increasing number of young women rendered infertile by cancer or cancer treatments.

4 Feb 2015

Researchers are one step closer to devising an approach to identify pancreatic cancer earlier

Pancreatic cancer affects approximately 46,000 people each year in the United States and ranks fourth among the leading causes of cancer-related deaths. Only about 6 percent of individuals with pancreatic cancer will live five years after their diagnosis.

3 Feb 2015

CellDetect urine test for detecting bladder cancer meets primary endpoint in multi-center clinical study

BioLight Life Sciences Investments Ltd., a firm that invests in, manages and commercializes biomedical innovations in ophthalmology and cancer diagnostics, announced today that a blinded, multi-center clinical study of the CellDetect non-invasive test for detecting bladder cancer in urine, successfully achieved the study's primary endpoint for effectively detecting the recurrence of bladder cancer in subjects with a history of the disease.

3 Feb 2015

Mesothelioma Victims Center implores US homeowners to understand the potential hazards of asbestos

The Mesothelioma Victims Center is urging all US homeowners to familiarize themselves with the dangers of exposure to asbestos in any home constructed with the material as there could be a remote possibility of developing a malignant form of cancer called mesothelioma.

2 Feb 2015

Survey results shows meningioma survivors more likely to want and intend to have baby

The diagnosis of a brain tumor—even one that's usually "benign" and slow growing such as a meningioma—can be scary.

2 Feb 2015

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 15 new Damon Runyon Fellows at its fall Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country.

31 Jan 2015

Breast and lung cancer patients with low levels of TTP protein have poorer prognosis

Moffitt Cancer Center researchers have found that breast and lung cancer patients who have low levels of a protein called tristetraprolin (TTP) have more aggressive tumors and a poorer prognosis than those with high levels of the protein.

31 Jan 2015

Alectinib active against leptomeningeal metastases in ALK-positive NSCLC

Patients with anaplastic lymphoma kinase-rearranged non-small-cell lung cancer who have leptomeningeal metastases may benefit from treatment with the second-generation ALK inhibitor alectinib, a case series suggests.

28 Jan 2015

Lund researchers find new way to identify malignant tumours in children

A research group at Lund University in Sweden has found a new way to identify the most malignant tumours in children. The method involves studying genetic 'micro-variation', rather than the presence of individual mutations.

28 Jan 2015

Novel technique could help identify cancerous tissue during brain tumor surgery

A novel radioguided surgery technique could quickly and effectively identify residual cancer cells during brain tumor surgery, with low radiation exposure for both patients and surgeons. The study, featured in the January 2015 issue of the Journal of Nuclear Medicine, reports that Y-90 DOTATOC, a beta-minus-emitting tracer, can effectively delineate the margins of meningiomas and high-grade gliomas.

28 Jan 2015

Researchers reveal role of epigenetic factors in malignant skin cancer

Melanoma, the most aggressive of all skin cancer strains, is often fatal for patients due to the pronounced formation of metastases. Until now, a melanoma's rampant growth was mainly attributed to genetic causes, such as mutations in certain genes. However, researchers from the University of Zurich now reveal that so-called epigenetic factors play a role in the formation of metastases in malignant skin cancer. This opens up new possibilities for future cancer treatments.

22 Jan 2015

Researchers identify promising new target for developing better therapies for neuroblastoma kids

Researchers at the University of Michigan's C.S. Mott Children's Hospital have identified a promising new target for developing new therapies for kids with high-risk neuroblastoma, according to a new study published in Molecular Cancer Research.

22 Jan 2015

Alzheimer's drug Aricept (donepezil) linked to serious side effects

New warnings have been added to the prescribing information for the Alzheimer's drug Aricept (donepezil) advising of the risk of two rare but potentially serious conditions: muscle breakdown (rhabdomyolysis) and a neurological disorder called neuroleptic malignant syndrome (NMS).

21 Jan 2015

Study: Mutated ATRX gene may serve as much-needed biomarker for rare neuroendocrine tumors

A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors. Now, for the first time, researchers at Penn's Abramson Cancer Center have found that the same mutated gene may serve as a much-needed biomarker for the pheochromocytomas and paragangliomas (PCC/PGL) that become malignant.

21 Jan 2015

Researchers invent new imaging system to help detect malignant tissue during surgery

With the goal of making it easier for surgeons to detect malignant tissue during surgery and hopefully reduce the rate of cancer recurrence, scientists have invented a new imaging system that causes tumors to "light up" when a hand-held laser is directed at them.

21 Jan 2015

Researchers identify ten new antibodies that can possibly prevent cancer tumours

Out of a library with billions of artificial antibodies, researchers have identified ten that can possibly prevent cancer tumours from growing.

20 Jan 2015

Malignant News and Research

Johns Hopkins researchers successfully deliver new nanoparticle gene therapy to treat glioma in rats

Genomics of papillary thyroid carcinoma (PTC): an interview with Professor Thomas J. Giordano

New study sheds light on syndrome linked to aggressive pediatric cancer

Researchers develop optimised PSA screening programme for prostate cancer

Oncology experts study use of fertility-sparing cancer treatments

Researchers are one step closer to devising an approach to identify pancreatic cancer earlier

CellDetect urine test for detecting bladder cancer meets primary endpoint in multi-center clinical study

Mesothelioma Victims Center implores US homeowners to understand the potential hazards of asbestos

Survey results shows meningioma survivors more likely to want and intend to have baby

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

Breast and lung cancer patients with low levels of TTP protein have poorer prognosis

Alectinib active against leptomeningeal metastases in ALK-positive NSCLC

Lund researchers find new way to identify malignant tumours in children

Novel technique could help identify cancerous tissue during brain tumor surgery

Researchers reveal role of epigenetic factors in malignant skin cancer

Researchers identify promising new target for developing better therapies for neuroblastoma kids

Alzheimer's drug Aricept (donepezil) linked to serious side effects

Study: Mutated ATRX gene may serve as much-needed biomarker for rare neuroendocrine tumors

Researchers invent new imaging system to help detect malignant tissue during surgery

Researchers identify ten new antibodies that can possibly prevent cancer tumours

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