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The effectiveness of nirmatrelvir therapy for preventing mortality and hospitalizations due to COVID-19 in high-risk patients during the Omicron surge

Researchers evaluated how effective nirmatrelvir is in preventing COVID-19-associated death and hospitalization in high-risk patients.

2 Jun 2022

Aromatherapy can help control pain and reduce opioid consumption, preliminary study suggests

Aromatherapy reduces post-surgical opioid use by half in hip replacement patients anxious before their operation, according to a new preliminary study being presented at the annual meeting of the European Society of Anaesthesiology and Intensive Care (ESAIC) in Milan, Italy (4-6 June).

2 Jun 2022

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Individuals with HIV who began taking antiretroviral therapy (ART) in the early stages of infection achieved a lengthy period of HIV suppression without ART after receiving two broadly neutralizing anti-HIV antibodies (bNAbs), according to a small study published today in the journal Nature.

1 Jun 2022

Study reveals the prevalence and determinants of eating problems among older home care clients

Eating problems are common among older home care clients, a new study from the University of Eastern Finland shows.

1 Jun 2022

Study may explain why people with both Type 1 and Type 2 diabetes are prone to tooth decay

People with both Type 1 and Type 2 diabetes are prone to tooth decay, and a new study from Rutgers may explain why: reduced strength and durability of enamel and dentin, the hard substance under enamel that gives structure to teeth.

31 May 2022

Study highlights clinical features and treatment approaches for human monkeypox in the UK

researchers from the UK unveil the details of imported, household, and hospital transmission of monkeypox and report the first usage of two specific antiviral agents in the treatment of this disease.

30 May 2022

Researchers develop oil-based gels as drug delivery systems for children in resource-limited countries

Administering medications to children poses unique challenges, especially in resource-limited countries with high infant and child mortality rates.

27 May 2022

Key immunological changes that support peanut allergy remission in children discovered

Australian researchers have discovered the key immunological changes that support the remission of peanut allergy in children, paving the way for new, more targeted treatments.

25 May 2022

Common prostate cancer medications may increase risk of serious metabolic or cardiovascular issues

Men taking either of the two most common oral medications for advanced prostate cancer who had also undergone hormone therapy to treat their disease were at higher risk of serious metabolic or cardiovascular issues than patients who were only receiving hormone therapy, Michigan Medicine researchers found.

25 May 2022

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

Researchers reviewed available mucosal vaccines discussing the current challenges and ways to advance the existing approaches.

25 May 2022

The effectiveness of molnupiravir and nirmatrelvir/ritonavir in reducing hospitalization and deaths in non-hospitalized COVID-19 patients

Researchers assessed the effectiveness of two orally administered antiviral medications, nirmatrelvir/ritonavir, and molnupiravir, in decreasing hospitalization and deaths among real-world non-hospitalized COVID-19 patients in Hong Kong.

25 May 2022

Anti-SARS-CoV-2 antibodies from breast milk persist in infants’ digestive tract

The current preliminary investigation study published in the journal Nutrients sought to investigate the longevity of anti-SARS-CoV-2 immunoglobulin (Ig)A and IgG in breast milk during the in vitro-simulated gastrointestinal digestion.

24 May 2022

Efficacy study of Paxlovid and Molnupiravir in real-world settings shows positive results

In a recent study posted to the medRxiv* pre-print server, researchers evaluated the effectiveness of oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals, molnupiravir (Lagevrio) or nirmatrelvir/ritonavir (Paxlovid) in a real-world setting.

24 May 2022

Medication, lifestyle intervention effective in preventing Type 2 diabetes, but not cardiovascular disease

A lifestyle intervention program of increased physical activity, healthy eating and aiming for weight loss of 7% or more, or taking the medication metformin were effective long-term to delay or prevent Type 2 diabetes in adults with prediabetes.

23 May 2022

Can human coronaviruses infect the GI tract?

Researchers review current findings on how human coronaviruses like SARS-CoV-2 might cause GI symptoms.

22 May 2022

Five medical organizations release new guidance for preventing hospital-acquired pneumonia

In the second in series of updates on guidance for infection control in acute-care hospitals, five medical organizations are recommending best practices for preventing hospital-associated pneumonia. Pneumonia is the most common and deadly healthcare-associated infection.

20 May 2022

UNC-Chapel Hill secures $65 million NIH grant for establishing Antiviral Drug Discovery Center

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health awarded the UNC Gillings School of Global Public Health a $65 million grant establishing an Antiviral Drug Discovery Center to develop oral antivirals that can combat pandemic-level viruses like COVID-19.

20 May 2022

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

A new study has revealed that ATV006, which is a 5′-hydroxyl-isobutyryl prodrug, possesses extraordinary oral pharmaco-kinetic (PK) profiles in rats and cynomolgus monkeys and exhibited significant antiviral activity against ancestral SARS-COV-2 strain as well as VOCs.

20 May 2022

Low-dose apixaban treatment reduces recurrence of venous thromboembolism compared to anticoagulant discontinuation after negative D-dimer

Patients who have suffered from a first episode of unprovoked venous thromboembolism (VTE) have an eight times higher risk of recurrence if they stop treatment after repeated negative D-dimer tests, instead of continuing with low-dose anticoagulant (apixaban).

20 May 2022

Existing drug may reduce damage after spinal cord injury, research shows

Scientists from the University of Birmingham have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord.

20 May 2022

Oral News and Research

The effectiveness of nirmatrelvir therapy for preventing mortality and hospitalizations due to COVID-19 in high-risk patients during the Omicron surge

Aromatherapy can help control pain and reduce opioid consumption, preliminary study suggests

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Study reveals the prevalence and determinants of eating problems among older home care clients

Study may explain why people with both Type 1 and Type 2 diabetes are prone to tooth decay

Study highlights clinical features and treatment approaches for human monkeypox in the UK

Researchers develop oil-based gels as drug delivery systems for children in resource-limited countries

Key immunological changes that support peanut allergy remission in children discovered

Common prostate cancer medications may increase risk of serious metabolic or cardiovascular issues

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

The effectiveness of molnupiravir and nirmatrelvir/ritonavir in reducing hospitalization and deaths in non-hospitalized COVID-19 patients

Anti-SARS-CoV-2 antibodies from breast milk persist in infants’ digestive tract

Efficacy study of Paxlovid and Molnupiravir in real-world settings shows positive results

Medication, lifestyle intervention effective in preventing Type 2 diabetes, but not cardiovascular disease

Can human coronaviruses infect the GI tract?

Five medical organizations release new guidance for preventing hospital-acquired pneumonia

UNC-Chapel Hill secures $65 million NIH grant for establishing Antiviral Drug Discovery Center

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

Low-dose apixaban treatment reduces recurrence of venous thromboembolism compared to anticoagulant discontinuation after negative D-dimer

Existing drug may reduce damage after spinal cord injury, research shows

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