Protein C News and Research

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Study clarifies role of KLF12 in CRC tumor growth

Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. Furthermore, data demonstrate that KLF12 and EGR1 levels synergistically correlate with poor CRC prognoses.

29 Jul 2016

Study verifies human gene therapy in MPS I animal model

Researchers are closer to finding a better way to treat children with a rare metabolic disorder called MPS I. It is caused by a deficiency of the key enzyme IDUA needed to break down complex sugars in cells.

29 Jul 2016

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Scientists have developed a new method of measuring the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease.

29 Jul 2016

New research sheds light on how fruit flies sense foods

Some people love avocados. Others hate them. For many of the latter, the fruit's texture is the source of their intense dislike. What gives?

29 Jul 2016

MIT researchers develop portable device to manufacture biopharmaceuticals on demand

For medics on the battlefield and doctors in remote or developing parts of the world, getting rapid access to the drugs needed to treat patients can be challenging.

29 Jul 2016

T-cell technology could be used to treat ovarian tumors with no adverse effects

With only incremental improvements in ovarian cancer survival over the last 40 years, there is a clear need for new treatment options with long-lasting results. Many researchers have turned toward the development of immunotherapies that direct T-cells to selectively eliminate ovarian tumor cells, but an appropriate therapeutic target for ovarian cancers has remained elusive.

29 Jul 2016

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease.

29 Jul 2016

Research findings may offer new way to strengthen body’s natural defenses to battle pneumonia

A molecule being targeted in cancer is also critical for the immune system's ability to battle pneumonia, researchers at the University of Virginia School of Medicine have determined.

29 Jul 2016

Blood pressure hormone system important for cardiovascular health can promote obesity

New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity.

29 Jul 2016

Human immune system proteins can help combat chlamydia infections

Scientists from Federal Research and Clinical Centre of Physical-Chemical Medicine, Koltzov Institute of Developmental Biology and MIPT have shown that peptidoglycan recognition proteins (PGLYRPs) of the human immune system can play a key role in the fight against chlamydia infections. Their study was published in Infection and Immunity.

28 Jul 2016

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

The formation of large numbers of polyps in the colon has a high probability of developing into colon cancer, if left untreated.

28 Jul 2016

Scientists identify mutation responsible for new, rare genetic disorder

An international team of researchers has discovered the mutation responsible for a rare, newly identified genetic disorder that causes craniofacial abnormalities and developmental delays.

28 Jul 2016

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

Although it reads like European license plate number, a protein known as ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center.

28 Jul 2016

Researchers develop new test for early detection of patients' resistance to leukemia treatment

Australian researchers have made a world-first breakthrough in the early detection of patients' resistance to a common treatment for chronic myeloid leukemia.

28 Jul 2016

Resveratrol may be clinically beneficial to people with Alzheimer's disease

Resveratrol, given to Alzheimer's patients, appears to restore the integrity of the blood-brain barrier, reducing the ability of harmful immune molecules secreted by immune cells to infiltrate from the body into brain tissues, say researchers at Georgetown University Medical Center.

28 Jul 2016

Higher nut intake linked to lower levels of inflammatory biomarkers

In a cross-sectional analysis published online today in the American Journal of Clinical Nutrition, researchers looked at the association between habitual nut consumption and inflammatory biomarkers among 5,013 men and women participating in two ongoing prospective cohort studies: the Nurses' Health Study and Health Professionals Follow-up Study.

28 Jul 2016

Updated guidelines for breast cancer increase number of patients who test HER2-positive

Changes to HER2 testing guidelines for breast cancer in 2013 significantly increased the number of patients who test HER2-positive, according to a new study by Mayo Clinic researchers published in the Journal of Clinical Oncology.

28 Jul 2016

New research elucidates details about architecture of synaptic transmission

For more than a century, neuroscientists have known that nerve cells talk to one another across the small gaps between them, a process known as synaptic transmission.

28 Jul 2016

UNMC researcher aims to find workable solution for tackling antibiotic resistance

Sam Sanderson, Ph.D., a research associate professor in the UNMC College of Pharmacy, recently secured an R01 grant from the National Institutes of Health to find a workable solution to the problem of antibiotic resistance.

28 Jul 2016

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

In addition to its more obvious ills, type 2 diabetes is a condition closely associated with bone fractures, increasing the risk of fractures twofold. To make matters worse, certain anti-diabetic drugs further increase this risk, particularly in postmenopausal women, severely limiting their treatment options.

28 Jul 2016

Protein C News and Research

Study clarifies role of KLF12 in CRC tumor growth

Study verifies human gene therapy in MPS I animal model

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

New research sheds light on how fruit flies sense foods

MIT researchers develop portable device to manufacture biopharmaceuticals on demand

T-cell technology could be used to treat ovarian tumors with no adverse effects

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Research findings may offer new way to strengthen body’s natural defenses to battle pneumonia

Blood pressure hormone system important for cardiovascular health can promote obesity

Human immune system proteins can help combat chlamydia infections

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

Scientists identify mutation responsible for new, rare genetic disorder

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

Researchers develop new test for early detection of patients' resistance to leukemia treatment

Resveratrol may be clinically beneficial to people with Alzheimer's disease

Higher nut intake linked to lower levels of inflammatory biomarkers

Updated guidelines for breast cancer increase number of patients who test HER2-positive

New research elucidates details about architecture of synaptic transmission

UNMC researcher aims to find workable solution for tackling antibiotic resistance

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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