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Nonmedical use of prescription opioids drops but overdose death rates rise in U.S.

From 2003 to 2013, the percentage of nonmedical use of prescription opioids decreased among adults in the U.S., while the prevalence of prescription opioid use disorders, frequency of use, and related deaths increased, according to a study in the October 13 issue of JAMA.

15 Oct 2015

BDSI announces FDA approval of BUNAVAIL sNDA for manufacturing specification change

BioDelivery Sciences International, Inc. announced that the U.S. Food and Drug Administration has approved the company's Supplemental New Drug Application (sNDA) for a manufacturing specification change for BUNAVAIL (buprenorphine and naloxone) buccal film (CIII).

15 Oct 2015

Neutrophils kill invading microorganisms, starve microbes to death

The most frequent immune cells in the human blood, so-called neutrophils, efficiently kill invading microorganisms and slowly starve microbes to death by removing crucial trace elements. This is shown by researchers from Umeå University in Sweden in a study published in a special issue of Metallomics.

15 Oct 2015

Loyola partners with Cook County Sheriff's Department to hold Medication Take-Back Day on October 20

Loyola University Health System will partner with the Cook County Sheriff's Department to hold a Medication Take-Back Day on Tuesday, October 20, 2015 from 9 am to 3 pm at the Loyola Outpatient Center lobby located at 2160 S. First Ave. in Maywood.

15 Oct 2015

Drug interactions in placenta may increase risk of birth defects or stunting fetal growth

To date, studies in pregnant women examining transport of drugs across the placenta are rare and inadequate, said Tomo Nabekura, PhD. Such knowledge could be vital to preserving fetal health. In a new laboratory study, Nabekura and colleagues have illuminated a piece of this puzzle, and the results hint that mothers taking new anti-hepatitis C and/or anti-HIV drugs along with anti-hypertensives or non-steroidal anti-inflammatories (NSAIDs) could be raising the risk of birth defects or stunting fetal growth, respectively.

15 Oct 2015

Poorly-designed animal study threatens validity of preclinical research

Badly designed studies may lead to the efficacy of drugs being overestimated and money being wasted on trials that prove fruitless, according to new a study from McGill University in Canada.

15 Oct 2015

CWRU investigator receives $2.82 million NIH grant to make stealth bombs for brain cancer treatment

A Case Western Reserve University researcher has received a 5-year, $2.82 million National Institutes of Health grant to make, in essence, stealth bombs that slip past the brain's defenses to attack an incurable form of cancer.

15 Oct 2015

New blood test could help pair cancer patients with suitable therapy for their disease

CANCER RESEARCH UK-funded scientists have developed a blood test that could help pair cancer patients with the most suitable therapy for their disease and then track the tumour's progress to see if the treatment is working, according to research published today (Thursday) in Clinical Cancer Research.

15 Oct 2015

Novel ligand peptide-mimic inhibits abnormal overgrowth of blood vessels, may lead to new anti-cancer drugs

An international research team led by scientists at the University of New Mexico Cancer Center discovered and developed a novel ligand peptide-mimic that inhibits abnormal overgrowth of blood vessels in retinal diseases and tumors. The discovery could lead to new drugs that keep cancers from growing. The team published a paper in the journal Science Translational Medicine.

15 Oct 2015

Different Crohn's disease treatments affect children's gut microbes in distinct ways

Different treatments for Crohn's disease in children affects their gut mi-crobes in distinct ways, which has implications for future development of microbial-targeted therapies for these patients, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Oct 2015

Long-term lithium exposure does not increase renal dysfunction risk

Stable lithium maintenance therapy does not increase the risk of renal dysfunction in patients with bipolar affective disorder, findings from a population-based study suggest.

14 Oct 2015

enGene, Janssen Biotech sign agreement to develop and commercialize new IBD therapies

enGene, Inc. a gene therapy company focused on development of therapeutics using its proprietary "Gene Pill" and enema gene delivery platform, today announced that it has entered into a definitive agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, to develop and commercialize new therapies for inflammatory bowel disease (IBD).

14 Oct 2015

Boehringer Ingelheim, Lilly announce availability of Synjardy tablets in U.S. pharmacies

Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company announced that Synjardy (empagliflozin/metformin hydrochloride) tablets are now available by prescription in pharmacies across the United States.

14 Oct 2015

Antipsychotic drugs more frequently used in Alzheimer's disease patients, new study finds

Antipsychotic drugs are initiated in patients with Alzheimer's disease (AD) more frequently than in the general population - already 2-3 years before the Alzheimer's diagnosis, according to a new study from the University of Eastern Finland.

14 Oct 2015

Researchers one step closer to finding effective drug for alcohol dependence

Researchers at Karolinska Institutet and the Sahlgrenska Academy in Sweden might be one step closer to finding an effective drug for alcohol dependence. In two separate studies, they show that the so-called dopamine stabilizer OSU6162 can reduce the craving for alcohol in alcohol dependent people and normalises the level of dopamine in the brain reward system of rats that have consumed alcohol over a long period of time.

14 Oct 2015

Thyroid hormone treatment improves cardiac health in female rats with high blood pressure

Thyroid hormones administered to female rats with high blood pressure led to encouraging cardiac improvements, according to a study in the American Journal of Physiology led by NYIT College of Osteopathic Medicine researcher Martin Gerdes.

14 Oct 2015

Researchers come up with new design for a better liposome

Using computational modeling, researchers at Carnegie Mellon University, the Colorado School of Mines and the University of California, Davis have come up with a design for a better liposome. Their findings, while theoretical, could provide the basis for efficiently constructing new vehicles for nanodrug delivery.

14 Oct 2015

Drugs News and Research

Nonmedical use of prescription opioids drops but overdose death rates rise in U.S.

BDSI announces FDA approval of BUNAVAIL sNDA for manufacturing specification change

Neutrophils kill invading microorganisms, starve microbes to death

Loyola partners with Cook County Sheriff's Department to hold Medication Take-Back Day on October 20

Drug interactions in placenta may increase risk of birth defects or stunting fetal growth

Poorly-designed animal study threatens validity of preclinical research

CWRU investigator receives $2.82 million NIH grant to make stealth bombs for brain cancer treatment

New blood test could help pair cancer patients with suitable therapy for their disease

Novel ligand peptide-mimic inhibits abnormal overgrowth of blood vessels, may lead to new anti-cancer drugs

Different Crohn's disease treatments affect children's gut microbes in distinct ways

Long-term lithium exposure does not increase renal dysfunction risk

enGene, Janssen Biotech sign agreement to develop and commercialize new IBD therapies

Boehringer Ingelheim, Lilly announce availability of Synjardy tablets in U.S. pharmacies

Antipsychotic drugs more frequently used in Alzheimer's disease patients, new study finds

Researchers one step closer to finding effective drug for alcohol dependence

Thyroid hormone treatment improves cardiac health in female rats with high blood pressure

Researchers come up with new design for a better liposome

CU Cancer Center study reports 'robust antitumor activity' of TAK-733 drug in mouse models of colorectal cancer

Researchers find significant link between breast cancer and nutrition, explore new preventative treatment

Researchers identify new therapeutic target for Duchenne muscular dystrophy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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