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NicOx updates on PF-03187207 and research collaboration with Pfizer

NicOx S.A. has announced the results of a dose-ranging phase 2 study conducted with PF‑03187207 in Japanese patients with glaucoma by its partner Pfizer Inc. PF-03187207 is a nitric oxide-donating prostaglandin analog. The study was designed to compare the safety and efficacy of several doses of PF-03187207 to Xalatan (latanoprost) and enrolled 112 Japanese patients with primary open-angle glaucoma or ocular hypertension.

25 Aug 2008

FDA approves Nplate (romiplostim), first bone marrow stimulator for chronic immune thrombocytopenic purpura

The U.S. Food and Drug Administration has approved Nplate (romiplostim), the first product that directly stimulates the bone marrow to produce needed platelets in patients with a rare blood disorder that can lead to serious bleeding.

24 Aug 2008

Why hormone therapy for prostate cancer fails

Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.

21 Aug 2008

Plastic coatings could help medical implants connect with neurons

Plastic coatings could someday help neural implants treat conditions as diverse as Parkinson's disease and macular degeneration.

21 Aug 2008

New imaging technology provides early diagnosis of osteoarthritis

A newly developed medical imaging technology may provide doctors with a long-awaited test for early diagnosis of osteoarthritis (OA), scientists from New York reported today at the 236th National Meeting of the American Chemical Society.

20 Aug 2008

Research indicates no justification for denying obese patients knee replacements

Research by scientists at the MRC Epidemiology Resource Centre at the University of Southampton, in collaboration with colleagues at the universities of Bristol, Oxford and Keele, has shown that there is no justification for denying obese patients knee replacement surgery.

20 Aug 2008

Simple bowel cancer test spots deadliest tumours

British scientists say a simple bowel cancer test could save thousands of lives by spotting the deadliest tumours.

20 Aug 2008

Obesity raises risks of serious gastrointestinal diseases

The prevalence of obesity and overweight in the United States coupled by the increased risk of gastrointestinal diseases related to obesity raises serious implications for the health of Americans. Several scientific studies in the August issue of The American Journal of Gastroenterology examine the association between obesity and the risk of colorectal cancer and gastroesophageal reflux disease, or GERD.

19 Aug 2008

Brachytherapy may benefit obese prostate cancer patients

Brachytherapy, also called seed implants, may be a more beneficial treatment than surgery or external beam radiation therapy for overweight or obese prostate cancer patients, according to a study published in the August issue of the International Journal of Radiation Oncology-Biology-Physics, the official journal of the American Society for Therapeutic Radiology and Oncology.

19 Aug 2008

Ultrasound imaging predicts heart attack risk

Repeat exams using widely available and inexpensive ultrasound imaging could help identify patients at high risk for a heart attack or other adverse cardiovascular events, according to a study published in the September issue of the journal Radiology.

19 Aug 2008

Attacking heart failure in the young

Pediatric cardiology experts from around the world will gather at the Indiana University School of Medicine for the inaugural Riley Heart Center Symposium on Cardiac Development Sept. 8-9 at Riley Hospital for Children.

19 Aug 2008

Chewing gum speeds up recovery from colon surgery

Scientists in Britain say chewing gum after colon surgery improves the recovery of the bowel.

19 Aug 2008

Urologists report success using robot-assisted surgery for urinary abnormality

Ashok Hemal, M.D., a urologic surgeon from Wake Forest University Baptist Medical Center, and colleagues have reported success using robot-assisted laparoscopic surgery to repair abnormal openings between the bladder and vagina known as fistulas. Reporting on their experience with seven patients, Hemal and colleagues have the world's largest known success with the procedure.

18 Aug 2008

Alternative vaccine strategy shows promise in prostate cancer patients

New research indicates that giving patients a continuous low dose of an immune system booster, a method known as metronomic dosing, as part of a therapeutic prostate cancer vaccine strategy is safe and produces similar immune responses and fewer side effects than the more common dosing method, which is not well tolerated by many patients. This study, led by researchers at that National Cancer Institute (NCI), part of the National Institutes of Health, was published in the Aug. 15, 2008, issue of Clinical Cancer Research.

17 Aug 2008

Risk of breast cancer recurring even after 5 years of therapy

New research has found that even after 5 years of systemic therapy, breast cancer patients still have a substantial risk of the disease recurring.

13 Aug 2008

Breast cancer patients still have risk of relapse after 5 years of systemic therapy

Breast cancer survivors continue to have a substantial risk of disease recurrence after five years of systemic therapy, according to a study published in the August 12 online issue of the Journal of the National Cancer Institute.

12 Aug 2008

Prostatectomy improves outcome of some men with prostate cancer over watchful waiting

Men with early prostate cancer who undergo radical prostatectomy have a lower rate of death due to prostate cancer than men who are followed without treatment, known as watchful waiting, according to a randomized controlled trial published in the August 12 online issue of the Journal of the National Cancer Institute.

12 Aug 2008

Precisely targeted radiation therapy can control limited cancer spread

Precisely targeted radiation therapy can eradicate all evidence of disease in selected patients with cancer that has spread to only a few sites, suggests the first published report from an ongoing clinical trial.

12 Aug 2008

Tiny, easy to insert heart pump aids critically ill patients

Cardiologists from the Heart Center at Wake Forest University Baptist Medical Center have added the world's smallest heart pump to their arsenal to help critically ill heart patients who are in advanced cardiac failure or shock. The device works by temporarily taking over the pumping function of the heart and providing time needed to initiate lifesaving interventions.

12 Aug 2008

Finding cancer's original cell key to treatments

Cancer biologists are turning their attention to the normal cells that give rise to cancers, to learn more about how tumor growth might be stopped at the earliest opportunity.

11 Aug 2008