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Combination of TXA709 and cefdinir demonstrates synergistic antibacterial activity against MRSA

TAXIS Pharmaceuticals, a drug-discovery company focused on developing a new class of antibiotic agents to treat life-threatening, multidrug-resistant bacterial infections, announced the presentation of results demonstrating the synergistic antibacterial activity of its lead clinical candidate, TXA709, when combined with cefdinir, a third-generation cephalosporin antibiotic.

19 Sep 2015

Manchester researchers reveal why ER+ breast cancer women develop resistance to hormone therapy

University of Manchester researchers funded by Breast Cancer Now have discovered a new explanation as to why women with oestrogen receptor positive (ER+) breast cancer develop resistance to hormone treatment, and a potential new approach to overcome the problem.

18 Sep 2015

PharmaMar begins phase II 'Basket' trial to evaluate safety, efficacy of PM1183 in advanced solid tumors

PharmaMar announced today the start of a multicenter, international, open-label, exploratory phase II "Basket" trial (NCT02454972) to evaluate the efficacy and safety of the anticancer agent PM1183 (lurbinectedin) in advanced solid tumors.

18 Sep 2015

Study confirms pathogenic role of beta amyloid in dementia as seen in AD and Down syndrome

More than five million Americans are living with Alzheimer's disease (AD). Of them, 400,000 also have Down syndrome. Both groups have similar looking brains with higher levels of the protein beta amyloid.

18 Sep 2015

UCPH, Beckman Coulter Genomics identify effects of cancer on protein signaling networks within human cells

Studies published of early results of the strategic collaboration between Beckman Coulter Genomics and Linding Lab at UCPH.

From Beckman Coulter Life Sciences - Automation and Genomics 18 Sep 2015

Obese patients with type 2 diabetes should be prioritised for obesity surgery over those without diabetes

New research published in The Lancet Diabetes & Endocrinology suggests that, when considering overall costs of healthcare, obese patients with type 2 diabetes, especially those with recent disease onset, should be prioritised for obesity surgery over those without type 2 diabetes, since many patients see a reversal of diabetes after surgery and thus need fewer expensive diabetes medications or treatment for complications in future.

18 Sep 2015

Researchers identify protein that regulates neuron growth

An international team of researchers, led by scientists at the National University of Singapore (NUS), has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells.

18 Sep 2015

Norwegian COPD sufferers prescribed more sedatives than psychiatric patients, shows study

New research has revealed that Norwegian COPD sufferers are prescribed even more sedatives than psychiatric patients. The researchers behind the study believe that this is problematic because the drugs in question are addictive and inhibit lung function.

18 Sep 2015

ACCC survey highlights challenges and recent trends in U.S. cancer programs

The Association of Community Cancer Centers (ACCC) recently released results of its sixth annual Trends in Cancer Programs survey, highlighting the challenges and recent trends seen in U.S. cancer programs.

18 Sep 2015

Specific biomarker predicts which HER2-negative breast cancer patients respond to targeted therapy

A multicenter team led by Case Western Reserve has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond — and which should switch to another kind of treatment.

18 Sep 2015

Experts recommend three simple steps to combat flu

Experts at the National Foundation for Infectious Diseases Influenza/Pneumococcal news conference today reinforced the important message of prevention this upcoming cold and flu season.

17 Sep 2015

Amgen, Xencor partner to develop and commercialize new therapeutics for cancer immunotherapy, inflammation

Amgen and Xencor, Inc. announced today that the two companies have entered into a research and license agreement to develop and commercialize novel therapeutics in the areas of cancer immunotherapy and inflammation.

16 Sep 2015

Exosomes provide a promising way to induce human stem cell differentiation

Regenerative medicine using stem cells is an increasingly promising approach to treat many types of injury. Transplanted stem cells can differentiate into just about any other kind of cell, including neurons to potentially reconnect a severed spinal cord and repair paralysis.

16 Sep 2015

Novel radiopharmaceutical probe has potential to save lives of patients with ischemic stroke

A novel radiopharmaceutical probe developed at Massachusetts General Hospital has the potential of providing physicians with information that could save the lives of patients with ischemic stroke or pulmonary embolism - conditions caused when important blood vessels are blocked by a clot that has traveled from another part of the body.

16 Sep 2015

Study reports use of new psychoactive drugs in US nationally representative survey

In recent years, there has been an increase in emergence and use of a variety of new drugs, so-called "novel psychoactive substances" (NPS) in the US and worldwide.

16 Sep 2015

Research examines effects of antidepressant use on health of mother and child

The use of antidepressants during pregnancy has no long term neurodevelopmental or behavioural effects on the child, however they may be associated with an increased risk of postpartum haemorrhage, suggests the findings from three studies published in BJOG: An International Journal of Obstetrics and Gynaecology (BJOG).

16 Sep 2015

Bionomics’ BNC210 Phase 1 trial for anxiety and depression meets primary endpoint

Bionomics Limited, a biopharmaceutical company focused on the discovery and development of innovative therapeutics for the treatment of diseases of the central nervous system (CNS) and cancer, today reported positive data from the completed Phase 1 multiple ascending dose, placebo controlled clinical trial of BNC210, an orally administered negative allosteric modulator of the alpha-7 nicotinic acetylcholine receptor (alpha-7 receptor) being developed for the treatment of anxiety and depression.

16 Sep 2015

Scientists find how cells adapt to overcome cancer drugs

CANCER RESEARCH UK scientists have found how cells adapt to overcome cancer drugs designed to interfere with their genetic controls, according to a study published today (Wednesday) in Epigenetics and Chromatin.

16 Sep 2015

Researchers use new synthetic method to prepare potential drug candidates for type 2 diabetes

Aryl alkyl ethers are important structural motifs found in many biologically active compounds. Therefore, stereoselective etherification is a highly important synthetic operation in the preparation of drug candidates.

16 Sep 2015

AstraZeneca presents safety and efficacy data for ExQW at 51st Annual Meeting of EASD

AstraZeneca today announced new analyses of exenatide once weekly (ExQW) demonstrating a favorable gastrointestinal (GI) tolerability profile, including less frequent upper and lower GI adverse events (AE), compared to shorter-acting glucagon-like peptide-1 receptor agonists (GLP-1RA), exenatide twice daily (ExBID) and liraglutide once daily (LiraQD).

16 Sep 2015

Drugs News and Research

Combination of TXA709 and cefdinir demonstrates synergistic antibacterial activity against MRSA

Manchester researchers reveal why ER+ breast cancer women develop resistance to hormone therapy

PharmaMar begins phase II 'Basket' trial to evaluate safety, efficacy of PM1183 in advanced solid tumors

Study confirms pathogenic role of beta amyloid in dementia as seen in AD and Down syndrome

UCPH, Beckman Coulter Genomics identify effects of cancer on protein signaling networks within human cells

Obese patients with type 2 diabetes should be prioritised for obesity surgery over those without diabetes

Researchers identify protein that regulates neuron growth

Norwegian COPD sufferers prescribed more sedatives than psychiatric patients, shows study

ACCC survey highlights challenges and recent trends in U.S. cancer programs

Specific biomarker predicts which HER2-negative breast cancer patients respond to targeted therapy

Experts recommend three simple steps to combat flu

Amgen, Xencor partner to develop and commercialize new therapeutics for cancer immunotherapy, inflammation

Exosomes provide a promising way to induce human stem cell differentiation

Novel radiopharmaceutical probe has potential to save lives of patients with ischemic stroke

Study reports use of new psychoactive drugs in US nationally representative survey

Research examines effects of antidepressant use on health of mother and child

Bionomics’ BNC210 Phase 1 trial for anxiety and depression meets primary endpoint

Scientists find how cells adapt to overcome cancer drugs

Researchers use new synthetic method to prepare potential drug candidates for type 2 diabetes

AstraZeneca presents safety and efficacy data for ExQW at 51st Annual Meeting of EASD

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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