Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Study sheds new light on left ventricular dysfunction in ischemic heart disease

Ischemic heart disease is a growing cause of heart failure owing to the increasing prevalence of diabetes, hypertension, and obesity.

17 Feb 2019

Study finds underutilization of aspirin to prevent colorectal cancer in high risk patients

Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor.

7 Feb 2019

Hypertension drug may improve effectiveness of ovarian cancer treatment

A new study from a Massachusetts General Hospital research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cancer

16 Jan 2019

Review highlights calcium handling mechanisms involved in reperfusion injury

Stroke and myocardial infarction (MI) are a significant cause of death and disability worldwide. However, over the past several decades because of advances in medicines (thrombolytic agents, antiplatelet drugs, beta blockers, and angiotensin converting enzyme inhibitors) and approaches to restore tissue perfusion (percutaneous coronary intervention and cardiopulmonary bypass), the mortality of MI has declined dramatically.

20 Dec 2018

FDA issues warning letter to Zhejiang Huahai Pharmaceutical involved in valsartan recall

The U.S. Food and Drug Administration today released a warning letter issued to Zhejiang Huahai Pharmaceutical Co. Ltd. (ZHP), in Linhai, Taizhou Zhejiang China, the manufacturer of the active pharmaceutical ingredient (API) found in valsartan that is the subject of an ongoing FDA investigation into probable cancer-causing impurities in certain commonly prescribed heart medicines.

12 Dec 2018

Low-salt diet may be more beneficial for females than males

A low-salt diet may be more beneficial in lowering blood pressure in females than males, report scientists who found that while actual salt retention isn't higher in females, there is still an effect that drives pressure up.

11 Dec 2018

Scientists identify new drug target for potential blood pressure treatment

Scientists have identified a key player in blood pressure regulation and have shown that switching it off reduces blood pressure in mice, according to new research in eLife.

6 Dec 2018

D-serine produced by gut microbiota protects against acute kidney injury, show study

The kidney is an organ not only for excreting body waste by urine but also for maintaining body homeostasis in close cooperation with other organs.

27 Nov 2018

Heart failure patients with stronger hearts have more depressive symptoms, lower quality of life

Heart failure patients fall into two general categories: those with weaker hearts, and those with stronger, but stiffer hearts that continue to eject the normal volume of blood with every beat.

20 Nov 2018

Angiotensin receptor blockers improve sodium excretion in blacks

Drugs that inhibit a hormone that constricts blood vessels also help improve sodium excretion in blacks who hold onto too much sodium in the face of stress, investigators report.

13 Nov 2018

Newly designed mice emulate severe form of kidney damage in humans with diabetes

Scientists led by Duke-NUS Medical School have designed mice that successfully emulate a severe form of kidney damage in humans with diabetes, called diabetic nephropathy.

9 Nov 2018

Common biomarker of kidney disease may also indicate COPD

A commonly used biomarker of kidney disease may also indicate lung problems, particularly COPD, or chronic obstructive pulmonary disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

28 Sep 2018

New statement provides detailed overview of how to diagnose, treat resistant hypertension

Resistant hypertension affects 12 percent to15 percent of patients treated for high blood pressure according to a new scientific statement from the American Heart Association.

14 Sep 2018

Blood pressure lowering therapy and statins continue to improve survival in patients with hypertension

Blood pressure and cholesterol lowering drugs continue to improve survival in patients with hypertension after more than a decade, according to late breaking results from the ASCOT Legacy study presented at ESC Congress 2018 and published in The Lancet.

28 Aug 2018

Blood pressure medication slows enlargement of the aorta in patients with Marfan syndrome

Treatment with a drug to lower blood pressure slows enlargement (dilatation) of the aorta in children and young adults with Marfan syndrome, according to late breaking results from the AIMS trial presented today in a Hot Line Session at ESC Congress 2018.

28 Aug 2018

Taking vacations could prolong life, suggests new study

Taking vacations could prolong life. That's the finding of a 40-year study presented today at ESC Congress and accepted for publication in The Journal of Nutrition, Health & Aging.

28 Aug 2018

Antithrombin drug does not reduce risk of myocardial infarction, stroke in heart failure patients

The antithrombin drug rivaroxaban does not reduce the risk of a composite endpoint of survival, myocardial infarction and stroke after an episode of worsening heart failure in patients with heart failure, sinus rhythm, and coronary artery disease, according to late breaking results from the COMMANDER HF trial presented today in a Hot Line Session at ESC Congress 2018 and with simultaneous publication in NEJM.

27 Aug 2018

$Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction$

Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction

Data from the TRANSITION study presented today at the European Society of Cardiology Congress in Munich, Germany has shown that Entresto® can be initiated early and safely in a wide range of heart failure patients with reduced ejection fraction who have been stabilized after hospitalization due to an acute heart failure episode.

25 Aug 2018

Drug in clinical trials for Parkinson's disease offers hope for treating heart failure

A drug currently in clinical trials for treating symptoms of Parkinson's disease may someday have value for treating heart failure, according to results of early animal studies by Johns Hopkins Medicine researchers.

20 Jul 2018

Plant-based products fail to have positive impact on blood pressure during clinical studies

In the high-pressure world of lowering hypertension, a surprising favorite isn't standing up too well in clinical trials.

17 Jul 2018

Angiotensin News and Research

Further Reading

Study sheds new light on left ventricular dysfunction in ischemic heart disease

Study finds underutilization of aspirin to prevent colorectal cancer in high risk patients

Hypertension drug may improve effectiveness of ovarian cancer treatment

Review highlights calcium handling mechanisms involved in reperfusion injury

FDA issues warning letter to Zhejiang Huahai Pharmaceutical involved in valsartan recall

Low-salt diet may be more beneficial for females than males

Scientists identify new drug target for potential blood pressure treatment

D-serine produced by gut microbiota protects against acute kidney injury, show study

Heart failure patients with stronger hearts have more depressive symptoms, lower quality of life

Angiotensin receptor blockers improve sodium excretion in blacks

Newly designed mice emulate severe form of kidney damage in humans with diabetes

Common biomarker of kidney disease may also indicate COPD

New statement provides detailed overview of how to diagnose, treat resistant hypertension

Blood pressure lowering therapy and statins continue to improve survival in patients with hypertension

Blood pressure medication slows enlargement of the aorta in patients with Marfan syndrome

Taking vacations could prolong life, suggests new study

Antithrombin drug does not reduce risk of myocardial infarction, stroke in heart failure patients

Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction

Drug in clinical trials for Parkinson's disease offers hope for treating heart failure

Plant-based products fail to have positive impact on blood pressure during clinical studies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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