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Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

In a new study, scientists identified an unmodified peptide addressing pre-hairpin spike (S) protein intermediate inhibiting SARS-CoV-2 infection.

15 Aug 2022

Is the level of circulating SARS-CoV-2 RNA or spike protein associated with acute disease severity?

Researchers investigated the levels of circulating SARS-CoV-2 spike protein and viral RNA among patients hospitalized with acute COVID-19 and in patients with and without post-acute sequelae of COVID-19.

15 Aug 2022

Do pre-existing antibodies alter the development of memory B cells in response to SARS-CoV-2 mRNA vaccination in humans?

Researchers explored how passive administration of monoclonal antibodies impact the development of immunological memory in response to COVID-19 vaccination.

15 Aug 2022

Mechanistic insights into engineered ACE2 receptor traps

Researchers determined the cryo-electron microscopic (cryo-EM) structures of engineered angiotensin-converting enzyme 2 (ACE2) receptor traps.

12 Aug 2022

Bispecific antibody exhibits high breadth and potency against SARS-CoV-2 Omicron sub-lineages

In a new study, researchers developed bispecific-antibodies (bsAbs) against SARS-CoV-2 Omicron sub-lineages.

12 Aug 2022

Influence of SARS-CoV-2 breakthrough infection and age on humoral immunity post-three-dose COVID-19 vaccination

In a new study, researchers briefly reported the effect of SARS-CoV-2 breakthrough infection and age on humoral immunity following triple-dose SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccination.

12 Aug 2022

How does COVID-19 increase clotting risk?

An in-depth review article describing coronavirus disease 2019 (COVID-19)-related coagulopathy has recently been published in the journal Nature Reviews Immunology.

11 Aug 2022

Study warns of a potential Sindbis virus epidemic in 2022

Researchers seek to raise awareness of a potentially impending Sindbis virus epidemic.

11 Aug 2022

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

Researchers demonstrated multiple routes SARS-CoV-2 might take to develop high-level resistance to nirmatrelvir, an oral antiviral targeting the 3C-like protease (3CLpro) of SARS-CoV-2.

11 Aug 2022

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Researchers described a novel protein subunit vaccine comprising the receptor-binding domain (RBD) of ancestral SARS-CoV-2 spike (S) protein, dimerized with an immunoglobulin (Ig)G1-fraction, crystallizable (Fc) domain.

11 Aug 2022

Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies

In a recent Biomaterials study, researchers developed AIEgen-embedded polystyrene (PS) nanoparticles-based LFIA that can accurately detect anti-SARS-CoV-2 NAb in serum samples of vaccinated individuals.

11 Aug 2022

Scientists develop nanoantidote to reduce acidosis in critically ill COVID-19 patients

A group of scientists from China has recently developed an antacid nanoantidote that can effectively ameliorate blood acidosis induced by SARS-CoV-2 infection.

11 Aug 2022

Repurposed drug shows promise as potential new treatment for motor neuron disease

A drug typically used to treat enlarged prostates and high blood pressure has shown promise as a potential new therapy for motor neuron disease (MND), according to a new study.

11 Aug 2022

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

In a study recently published in Cancer Research, a journal of the American Association for Cancer Research, a team of researchers led by C. Patrick Reynolds, M.D., Ph.D., director for the Texas Tech University Health Sciences Center School of Medicine Cancer Center, sought to expand upon his lab's previous research that showed ALT tumors identified by a biomarker known as C-circles share a common biology that confers vulnerabilities to be exploited for cancer therapy.

10 Aug 2022

Enzyme News and Research

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

Is the level of circulating SARS-CoV-2 RNA or spike protein associated with acute disease severity?

Do pre-existing antibodies alter the development of memory B cells in response to SARS-CoV-2 mRNA vaccination in humans?

Mechanistic insights into engineered ACE2 receptor traps

Bispecific antibody exhibits high breadth and potency against SARS-CoV-2 Omicron sub-lineages

Influence of SARS-CoV-2 breakthrough infection and age on humoral immunity post-three-dose COVID-19 vaccination

How does COVID-19 increase clotting risk?

Study warns of a potential Sindbis virus epidemic in 2022

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies

Scientists develop nanoantidote to reduce acidosis in critically ill COVID-19 patients

Repurposed drug shows promise as potential new treatment for motor neuron disease

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

Review of natural products with promising anti-SARS-CoV-2 potential

The features of the newly emerging SARS-CoV-2 Omicron BA.2.75 subvariant

Scientists present highly accurate novel framework for SARS-CoV-2 genomic surveillance

Researchers explore SARS-CoV-2 entry route and downstream cellular and viral processes

Coronavirus biology: viral RNA synthesis, origin, and vaccines

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo