Pathogen News and Research

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Scientists report the first map of molecular responses of human lung cells to SARS-CoV-2 infection

In a multi-group collaborative involving the National Emerging Infectious Disease Laboratories (NEIDL), the Center for Regenerative Medicine (CReM), and the Center for Network Systems Biology (CNSB), scientists have reported the first map of the molecular responses of human lung cells to infection by SARS-CoV-2.

2 Dec 2020

Scientists identify mechanisms behind inflammasome activation by fungal pathogens

Scientists at St. Jude Children's Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus.

2 Dec 2020

The UK approves Pfizer vaccine for December 2020 roll out

The UK approves Pfizer vaccine and schedules phased vaccination process, commencing December 2020.

2 Dec 2020

New and sudden headaches may be a symptom of COVID-19

Researchers report a case of a young male patient who came in with a headache to an emergency room. He had increased intracranial pressure and tested positive for SARS-CoV-2, suggesting new headaches during the pandemic should not be ignored.

2 Dec 2020

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

A team of researchers at the University of Tokyo in Japan have detected a sarbecovirus, called Rc-o319, which is phylogenetically positioned in the same clade as SARS-CoV-2 in Rhinolophus cornutus bats in Japan.

2 Dec 2020

New lab-on-a-chip can process and present results rapidly

The chip, developed at Imperial College London and known as TriSilix, is a 'micro laboratory' which performs a miniature version of the polymerase chain reaction (PCR) on the spot. PCR is the gold-standard test for detecting viruses and bacteria in biological samples such as bodily fluids, faeces, or environmental samples.

2 Dec 2020

Particulate matter levels can play a significant role in SARS-CoV-2 transmission

A new study has found that particulate matter (PM) plays a role in providing surfaces for SARS-CoV-2 transmission and interaction, enabling fomite transmission through deposition.

2 Dec 2020

SARS-CoV-2 deletion mutations may have attenuated infectivity in some strains

A team of researchers at the University of Hong Kong has identified a panel of SARS-CoV-2 variants, called Del-mut, which contains a deletion in the S1/S2 junction. Upon investigating one of the deleted variants in animal models, they found that Del-mut-1 is attenuated in its ability to cause disease or pathological changes.

2 Dec 2020

Tecan launches rapid viral and pathogen characterization RNA-Seq library preparation solution for challenging sample types

Tecan has launched the Revelo RNA-Seq kit, offering end-to-end processing of human samples to enable complete viral RNA-Seq library preparation in a day.

From Tecan 2 Dec 2020

New combination therapy may help fight antimicrobial resistance

An inexpensive, FDA-approved drug -- cholestyramine -- taken in conjunction with an antibiotic prevents the antibiotic from driving antimicrobial resistance, according to new research by scientists at Penn State and the University of Michigan. The team's findings appear today (Dec. 1) in the journal eLife.

2 Dec 2020

Study shows how parasite that causes Chagas disease resists current therapies

New insight on how a parasite can resist current therapies has been published today in the open-access eLife journal.

2 Dec 2020

Immune mechanism in COVID-19 patients triggers cytokine storm

Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death.

2 Dec 2020

Nanomedicine's giant step into the fight against the COVID-19

A recent editorial in Nature Nanotechnology discusses the enormous feat of scientific innovation, with messenger RNA (mRNA)-based vaccines developed to deliver the gene sequence of specific SARS-CoV-2 viral proteins into host cells using nanotechnology platforms.

1 Dec 2020

Altered smell and taste impacts psychological wellbeing of COVID-19 survivors, study finds

A recent study discloses that loss of taste and smell sensation after infection with SARS-CoV-2 negatively impacts the quality of life and psychological wellbeing of those that recover but experience persistence of this symptom.

1 Dec 2020

Potential SARS-CoV-2 antiviral: Ionophore X-206 found to inhibit viral replication in cell cultures

In a study published in the journal Antiviral Research, researchers from Aarhus University, Denmark, report on their tests on different polyether ionophores to inhibit SARS-CoV-2 in vitro.

1 Dec 2020

SARS-CoV-2's microRNAs may have promoted its jump to humans

A new study uses machine learning to explore the small microRNAs (or miRNAs) of SARS-CoV-2 that may determine the virus's ability to successfully infect humans by altering the course of transcriptional events.

1 Dec 2020

COVID-19 restrictions have led to 86 percent drop in norovirus infections in US, finds study

The onset of the COVID-19 pandemic led to the imposition of several non-pharmaceutical interventions (NPIs) across the world. While citizens in the USA have been chafing over the advice to wear masks in public, restricted social interactions, and limited attendance at schools, colleges and workplaces, a new study published on the preprint server medRxiv* in November 2020 reports that these NPIs were linked to a steep reduction in the incidence of the non-respiratory pathogen, noroviruses.

1 Dec 2020

New combination technique separates cell types, may prove effective against pathogens

To develop effective therapeutics against pathogens, scientists need to first uncover how they attack host cells. An efficient way to conduct these investigations on an extensive scale is through high-speed screening tests called assays.

1 Dec 2020

Memory B cells persist in recovered COVID-19 patients

A team of scientists from the University of Washington, USA, and the Karolinska Institute, Sweden, has comprehensively studied the antibody-mediated immune responses in patients diagnosed with coronavirus disease 2019 (COVID-19).

30 Nov 2020

Highly functional immune response in asymptomatic SARS-CoV-2 infection

Researchers in Singapore have conducted a study showing that asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – mount an efficient, balanced and coordinated cellular immune response that protects the host without appearing to trigger any pathological processes.

30 Nov 2020

Pathogen News and Research

Scientists report the first map of molecular responses of human lung cells to SARS-CoV-2 infection

Scientists identify mechanisms behind inflammasome activation by fungal pathogens

The UK approves Pfizer vaccine for December 2020 roll out

New and sudden headaches may be a symptom of COVID-19

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

New lab-on-a-chip can process and present results rapidly

Particulate matter levels can play a significant role in SARS-CoV-2 transmission

SARS-CoV-2 deletion mutations may have attenuated infectivity in some strains

Tecan launches rapid viral and pathogen characterization RNA-Seq library preparation solution for challenging sample types

New combination therapy may help fight antimicrobial resistance

Study shows how parasite that causes Chagas disease resists current therapies

Immune mechanism in COVID-19 patients triggers cytokine storm

Nanomedicine's giant step into the fight against the COVID-19

Altered smell and taste impacts psychological wellbeing of COVID-19 survivors, study finds

Potential SARS-CoV-2 antiviral: Ionophore X-206 found to inhibit viral replication in cell cultures

SARS-CoV-2's microRNAs may have promoted its jump to humans

COVID-19 restrictions have led to 86 percent drop in norovirus infections in US, finds study

New combination technique separates cell types, may prove effective against pathogens

Memory B cells persist in recovered COVID-19 patients

Highly functional immune response in asymptomatic SARS-CoV-2 infection

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