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Newly discovered prion causes Multiple System Atrophy

Multiple System Atrophy (MSA), a neurodegenerative disorder with similarities to Parkinson's disease, is caused by a newly discovered type of prion, akin to the misfolded proteins involved in incurable progressive brain diseases such Creutzfeldt-Jakob Disease (CJD), according to two new research papers led by scientists at UC San Francisco.

1 Sep 2015

Bionomics submission of BNC101 IND for cancer treatment passes FDA review

Bionomics Limited, a biopharmaceutical company focused on the discovery and development of innovative therapeutics for the treatment of diseases of the central nervous system (CNS) and cancer, today announced that its BNC101 IND submission has passed review by the US Food and Drug Administration (FDA).

31 Aug 2015

Soligenix completes enrolment in SGX942 Phase 2 trial for oral mucositis in cancer patients

Soligenix, Inc., a late-stage biopharmaceutical company developing products that address unmet medical needs in the areas of inflammation, oncology and biodefense, announced today it has completed enrollment of the additional subjects, as directed by the Data Review Committee (DRC) earlier this year, into the company's Phase 2 study for SGX942.

31 Aug 2015

Scientists identify new protein that regulates severity of tissue damage caused by RA

Scientists have identified a new protein (C5orf30) which regulates the severity of tissue damage caused by rheumatoid arthritis (RA), an autoimmune disease that causes inflammation, pain, stiffness and damage to the joints of the feet, hips, knees, and hands.

31 Aug 2015

ELIXA trial results demonstrate cardiovascular safety of lixisenatide drug

In patients with type 2 diabetes and acute coronary syndrome, the glucose-lowering medication lixisenatide did not increase or decrease the rate of cardiovascular (CV) events compared to placebo, according to results of the Evaluation of Lixisenatide in Acute Coronary Syndrome (ELIXA) trial.

31 Aug 2015

Phase III trial results show cariprazine effective in treating negative symptoms associated with schizophrenia

Results of a clinical trial seem to show the first effective treatment for the negative symptoms - withdrawal, lack of emotion, and apathy - associated with schizophrenia.

31 Aug 2015

Study finds no significant impact of ATP on reducing late recurrence of AF

Late recurrence of atrial fibrillation (AF) is not reduced in patients whose pulmonary vein isolation (PVI) treatment incorporates the addition of adenosine triphosphate (ATP), according to results of the UNDER-ATP trial.

31 Aug 2015

Midday naps linked to reduced blood pressure levels, fewer antihypertensive medications

Midday naps are associated with reduced blood pressure levels and prescription of fewer antihypertensive medications, according to research presented at ESC Congress today by Dr Manolis Kallistratos, a cardiologist at Asklepieion Voula General Hospital in Athens, Greece.

29 Aug 2015

September tip sheet from Cedars-Sinai Medical Center

A computer algorithm did a better job than doctors at documenting "red flag" symptoms among patients with gastrointestinal disorders, a Cedars-Sinai study has found, underscoring the potential of the technology to improve patient care.

29 Aug 2015

Synthetic tissue environment enables spatial definition of cancer cells and macrophages

Tumors are notoriously difficult to study in their natural habitat - body tissues - but a new synthetic tissue environment may give cancer researchers the next-best look at tumor growth and behavior.

29 Aug 2015

New treatment algorithm for pulmonary arterial hypertension launched in 2015 ESC/ERS Guidelines

A novel treatment algorithm for pulmonary arterial hypertension is launched today in new pulmonary hypertension guidelines from the European Society of Cardiology and European Respiratory Society.

29 Aug 2015

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Engineers at the University of Toronto just made assembling functional heart tissue as easy as fastening your shoes. The team has created a biocompatible scaffold that allows sheets of beating heart cells to snap together just like Velcro™.

29 Aug 2015

Researchers examine how patients handle stigma of using medical marijuana

Research recently published in Journal of Psychoactive Drugs (Routledge) examines the experiences of California residents who have been prescribed medical marijuana and the stigma they experience from public opinion. The findings indicate that the stigma of using medical marijuana may contribute to the under-treatment of those who might benefit from medical marijuana.

29 Aug 2015

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Viruses are able to redirect the functioning of cells in order to infect them. Inspired by their mode of action, scientists from the CNRS and Université de Strasbourg have designed a "chemical virus" that can cross the double lipid layer that surrounds cells, and then disintegrate in the intracellular medium in order to release active compounds.

29 Aug 2015

Passport Health participates in clinical study to test effects of oral typhoid vaccination

Passport Health, in partnership with vaccine manufacturer PaxVax, Inc. is participating in a clinical study to test the effects of the oral typhoid vaccination, Vivotif (Typhoid Vaccine Live Oral Ty21a). The study will look at the side effects that could occur when taking Vivotif across the range of approved potencies.

28 Aug 2015

Researchers provide new insights into biology of aging, age-related diseases

The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging Prof. Robert J. Shmookler Reis (current world record holder in life extension for model animals - 10 fold for nematodes) has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks.

28 Aug 2015

Can-Fite BioPharma announces Q2 financial results for 2015, updates drug development programs

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs being developed to treat inflammatory diseases, cancer and sexual dysfunction, today reported financial results for the six months ended June 30, 2015 and updates on its drug development programs.

28 Aug 2015

Findings reveal a new way to prevent meningitis

The fungus Cryptococcus causes meningitis, a brain disease that kills about 1 million people each year — mainly those with impaired immune systems due to AIDS, cancer treatment or an organ transplant.

28 Aug 2015

ACR commends FDA’s draft guidance requiring distinct names for biosimilars, biologic therapies

The American College of Rheumatology (ACR) today praised the Food and Drug Administration (FDA) for issuing draft guidance requiring separate and distinct names for biosimilars and biologic therapies.

28 Aug 2015

AMCP issues statement in response to FDA’s draft guidance requiring nonproprietary names for biological products

The Academy of Managed Care Pharmacy (AMCP) is disappointed in the Food and Drug Administration's (FDA's) draft guidance and proposed rule that calls for biologics, including reference products and biosimilars, to bear a nonproprietary name with an FDA-designated suffix.

28 Aug 2015

Drugs News and Research

Newly discovered prion causes Multiple System Atrophy

Bionomics submission of BNC101 IND for cancer treatment passes FDA review

Soligenix completes enrolment in SGX942 Phase 2 trial for oral mucositis in cancer patients

Scientists identify new protein that regulates severity of tissue damage caused by RA

ELIXA trial results demonstrate cardiovascular safety of lixisenatide drug

Phase III trial results show cariprazine effective in treating negative symptoms associated with schizophrenia

Study finds no significant impact of ATP on reducing late recurrence of AF

Midday naps linked to reduced blood pressure levels, fewer antihypertensive medications

September tip sheet from Cedars-Sinai Medical Center

Synthetic tissue environment enables spatial definition of cancer cells and macrophages

New treatment algorithm for pulmonary arterial hypertension launched in 2015 ESC/ERS Guidelines

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Researchers examine how patients handle stigma of using medical marijuana

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Passport Health participates in clinical study to test effects of oral typhoid vaccination

Researchers provide new insights into biology of aging, age-related diseases

Can-Fite BioPharma announces Q2 financial results for 2015, updates drug development programs

Findings reveal a new way to prevent meningitis

ACR commends FDA’s draft guidance requiring distinct names for biosimilars, biologic therapies

AMCP issues statement in response to FDA’s draft guidance requiring nonproprietary names for biological products

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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