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Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Researchers have discovered how a common mutation in a high-risk leukemia subtype drives the cancer's aggressiveness and have identified drugs that may work with existing precision medicines to improve survival. St. Jude Children's Research Hospital scientists led the study, which was published online today in the journal Cancer Cell.

28 Aug 2015

New study provides framework for establishing value-based pricing for new cancer drugs

At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the marketplace. Using a highly sophisticated economic model, researchers from Winship Cancer Institute of Emory University and Georgia Institute of Technology used an example of a new lung cancer drug.

28 Aug 2015

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and sometimes debilitating condition. The findings by a team from the University of Pittsburgh School of Medicine were published online in the journal eLife.

28 Aug 2015

Adaptive immune system plays active role in guiding development of mammary glands

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty.

28 Aug 2015

Lack of professional guidance on The Physician Payments Sunshine Act may hinder participation in clinical trials

A research article, published today in Postgraduate Medicine, has concluded that a lack of professional guidance on how to interpret elements of The Physician Payments Sunshine Act (2010) may be having a "chilling effect" on physicians' desire to participate in clinical trials and publish results.

28 Aug 2015

Brain scans may help predict patients' response to antipsychotic drug treatment

Investigators at The Feinstein Institute for Medical Research have discovered that brain scans can be used to predict patients' response to antipsychotic drug treatment. The findings are published online in the latest issue of The American Journal of Psychiatry.

28 Aug 2015

Key modifiable Alzheimer’s risk factors pinpointed

A meta-analysis has identified the key modifiable factors associated with an increased or decreased risk of Alzheimer’s disease.

27 Aug 2015

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system.

27 Aug 2015

Health providers still prescribing expensive malaria drugs in Nigeria to patients who do not have malaria

Health providers trained to perform malaria rapid diagnostic tests (RDT) are still prescribing valuable malaria medicines to patients who do not have malaria, according to new research published in PLOS ONE.

27 Aug 2015

New test predicts breast cancer relapse months in advance

UK-based researchers have developed a blood test that can predict whether patients with breast cancer will experience a relapse after receiving treatment, months before tumors are visible using hospital scans.

27 Aug 2015

Nitroglycerin can be repurposed to treat cancer, researchers find

For over a century, nitroglycerin has been used medically - particularly in the treatment of angina, or chest pain. It is a safe, cheap and effective treatment. Now, according to the latest study in ecancermedicalscience, researchers find that nitroglycerin is the latest in a series of medicines that could be repurposed to treat cancer.

27 Aug 2015

University of Nottingham to lead £6.5m research project that aims to develop next generation biomaterials

The University of Nottingham is to lead a £6.5m research project which aims to make the leap from 2D to 3D in the development of advanced materials and realise the true potential of regenerative medicine and medical devices for the future.

27 Aug 2015

Researchers design online database to help researchers identify cancer gene mutations

Many clinical trials use genome sequencing to learn which gene mutations are present in a patient's tumor cells. The question is important because targeting the right mutations with the right drugs can stop cancer in its tracks. But it can be difficult to determine whether there is evidence in the medical literature that particular mutations might drive cancer growth and could be targeted by therapy, and which mutations are of no consequence.

27 Aug 2015

Founder of ACPA discusses how patient with chronic pain can tackle their NSAID usage

When a patient with chronic pain is experiencing symptoms, relief is only thing on their mind. NSAIDs, or nonsteroidal anti-inflammatory drugs, can often provide that relief, however it's important to balance the potential benefits with the potential risks of these drugs.

27 Aug 2015

Yale study identifies new barrier to caring for chronic hepatitis C patients

Nearly one in four patients with chronic hepatitis C (HCV) are denied initial approval for a drug therapy that treats the most common strain of the infection, according to a Yale School of Medicine study.

27 Aug 2015

Individuals having high blood levels of two closely related proteins experience few adverse health events

Individuals previously diagnosed with heart disease may be less likely to experience heart failure, heart attacks, or stroke, or to die from these events, if they have higher blood levels of two very closely related proteins, according to a new study led by a UC San Francisco research team.

27 Aug 2015

Researchers find that 26% of senior oncology patients use complementary or alternative medicines

Alternative medicines are widely thought to be at least harmless and very often helpful for a wide range of discomforts and illnesses. However, although they're marketed as "natural," they often contain active ingredients that can react chemically and biologically with other therapies.

27 Aug 2015

Paramedic care improves survival for paediatric patients who suffer cardiac arrest outside of hospital

Less than 10 per cent of paediatric patients who suffer a cardiac arrest outside of the hospital survive. There are many factors which can influence survival rates; paramedic care is one of them.

26 Aug 2015

UH research points to promising target in treatment of pancreatic cancer

Pancreatic cancer is extremely deadly and often has a poor prognosis. Ranked as the fourth deadliest cancer in the U.S. and poised to move up within the next few years, pancreatic cancer is very difficult to detect in its early stages. Seldom diagnosed early and typically spreading rapidly, the disease has no effective treatment once it advances.

26 Aug 2015

New research could potentially yield novel platform for cancer vaccines

New research led by Wyss Core Faculty member David Mooney, Ph.D., in collaboration with researchers at the Dana-Farber Cancer Institute could potentially yield a new platform for cancer vaccines. Leveraging a biologically inspired sponge-like gel called "cryogel" as an injectable biomaterial, the vaccine delivers patient-specific tumor cells together with immune-stimulating biomolecules to enhance the body's attack againstcancer.

26 Aug 2015

Drugs News and Research

Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

New study provides framework for establishing value-based pricing for new cancer drugs

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Adaptive immune system plays active role in guiding development of mammary glands

Lack of professional guidance on The Physician Payments Sunshine Act may hinder participation in clinical trials

Brain scans may help predict patients' response to antipsychotic drug treatment

Key modifiable Alzheimer’s risk factors pinpointed

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Health providers still prescribing expensive malaria drugs in Nigeria to patients who do not have malaria

New test predicts breast cancer relapse months in advance

Nitroglycerin can be repurposed to treat cancer, researchers find

University of Nottingham to lead £6.5m research project that aims to develop next generation biomaterials

Researchers design online database to help researchers identify cancer gene mutations

Founder of ACPA discusses how patient with chronic pain can tackle their NSAID usage

Yale study identifies new barrier to caring for chronic hepatitis C patients

Individuals having high blood levels of two closely related proteins experience few adverse health events

Researchers find that 26% of senior oncology patients use complementary or alternative medicines

Paramedic care improves survival for paediatric patients who suffer cardiac arrest outside of hospital

UH research points to promising target in treatment of pancreatic cancer

New research could potentially yield novel platform for cancer vaccines

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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