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Researchers identify novel protein that explains how biological clocks regulate human sleep

In a series of experiments sparked by fruit flies that couldn't sleep, Johns Hopkins researchers say they have identified a mutant gene - dubbed "Wide Awake" - that sabotages how the biological clock sets the timing for sleep.

17 Mar 2014

Researchers identify two novel genes associated with development of rare, aggressive blood cancer

Researchers have identified two novel cancer genes that are associated with the development of a rare, highly aggressive, cancer of blood vessels. These genes may now act as markers for future treatments and explain why narrowly targeted therapies that are directed at just one target fail.

17 Mar 2014

Scientists discover gene variation that makes humans have healthier blood lipid levels, reduced risk of heart attacks

Scientists have discovered a previously unrecognized gene variation that makes humans have healthier blood lipid levels and reduced risk of heart attacks -- a finding that opens the door to using this knowledge in testing or treatment of high cholesterol and other lipid disorders.

17 Mar 2014

Researchers use computer-aided design tool to create genetic languages of biological systems

Researchers at Virginia Tech and the Massachusetts Institute of Technology have used a computer-aided design tool to create genetic languages to guide the design of biological systems.

14 Mar 2014

CNIO scientist wins 2014 Stewart Rahr-PCF Young Investigator Award from Prostate Cancer Foundation

David Olmos, the Spanish National Cancer Research Centre's Head of the Prostate Cancer and Genitourinary Tumours Clinical Research Unit, has won the 2014 Stewart Rahr-PCF Young Investigator Award, endowed by the Prostate Cancer Foundation - the leading philanthropic organisation for cutting-edge research into prostate cancer.

14 Mar 2014

Japanese PAH patient prognosis ‘good’

Japanese patients respond well to pulmonary arterial hypertension-targeted drugs and may have a good prognosis with long-term survival, study findings suggest.

13 Mar 2014

SAGE Therapeutics announces completion of $38 million Series C financing

SAGE Therapeutics, a biopharmaceutical company developing novel medicines to treat specialty, critical and orphan central nervous system (CNS) disorders, today announced the successful completion of a $38 million Series C financing. OrbiMed Advisors, LLC, EcoR1 Capital Management, Foresite Capital Management and two undisclosed blue chip public investment funds joined existing investors Third Rock Ventures and ARCH Venture Partners.

13 Mar 2014

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

13 Mar 2014

Study: Musical aptitude is affected by a combination of genes involved in auditory pathway

Multiple regions in the human genome are reported to be linked to musical aptitude, according to a study published this week in Molecular Psychiatry.

13 Mar 2014

Microbial DNA may be involved in the development of autoimmune processes, shows study

The interactions of the gut microbiota in children with typical diabetes autoantibodies differ from that in healthy children. The fact that these differences already exist before antibodies are detectable in the blood adds to the growing evidence that microbial DNA, the so-called microbiome, may be involved in the development of autoimmune processes.

13 Mar 2014

Patients with congenital disorders are urged to register with CMDIR to advance clinical trials

If you are affected by Malignant Hyperthermia, Congenital Muscular Dystrophies or Congenital Myopathy Subtypes, the Malignant Hyperthermia Association of the United States and the Cure Congenital Muscle Disease organization are asking for your help to enable research and clinical trials by registering with the Congenital Muscle Disease International Registry (CMDIR).

13 Mar 2014

Roy Castle Lung Cancer Foundation funds two new projects to support research into lung cancer

The Roy Castle Lung Cancer Foundation has funded two new projects at the University of Liverpool which aim to improve survival rates for the UK's biggest cancer killer.

13 Mar 2014

Blocking function of enzyme slows spread of pancreatic cancer, say researchers

A research team from Imperial College London has shown that blocking the function of an enzyme known as Hhat slows the growth and spread of pancreatic cancer, by preventing a protein called Hedgehog from stimulating nearby normal cells to help the cancer.

13 Mar 2014

N30 Pharma begins oral dosing in N91115 Phase 1 trial for treatment of cystic fibrosis

N30 Pharmaceuticals, Inc. announced today that it has begun oral dosing of N91115 in a Phase 1 clinical trial. N91115, a novel inhibitor of S-nitrosoglutathione reductase (GSNOR), is being developed for the treatment of cystic fibrosis (CF).

12 Mar 2014

Three innovative tools to detect, test and initiate personalized drug treatment for seizures

A team of researchers from the National Institutes of Health, Emory University and Cedars-Sinai - specialists in identifying and treating very rare diseases - used three innovative tools to detect a previously unknown gene mutation, test potential therapies in the lab, and initiate personalized drug treatment for a boy with a lifelong history of uncontrollable seizures that caused significant impact on his cognitive and social development.

12 Mar 2014

Researchers explore how genetics affects causes and prevalence of preterm birth

More than 450,000 babies are born too soon each year in the U.S. Preterm birth is a serious health problem that costs the nation more than $26 billion annually, according to the Institute of Medicine, and is the leading cause of newborn death.

12 Mar 2014

Cancer doctors push for payment changes

Also, some health companies are trying to improve patient outcomes by using predictive software to deliver care more efficiently, and a company lost another court decision to patent a genetic test.

12 Mar 2014

Study finds link between elevated urinary Gb3 and heart disease

A special newly discovered biomarker, "Gb3," potentially related to the survival of heart disease patients, could change the way the country's No. 1 killer is monitored in the future, according to research published in the Feb. 4 edition of the Journal of the American Heart Association.

11 Mar 2014

Compensatory brain mechanisms at play in siblings of bipolar patients

Patients with bipolar disorder and their unaffected siblings have deficits in a part of the brain responsible for automatic regulation of emotions, report researchers.

11 Mar 2014

Researchers discover two new gene regions connected to bipolar disorder

First on top of the world and then in the depths of despair - this is what the extreme mood changes for people with bipolar disorder are like. Under the direction of scientists from Bonn, Mannheim and Basel, an international collaboration of researchers discovered two new gene regions that are connected to the prevalent disease. In addition, they were able to confirm three additional suspect genes.

11 Mar 2014

Genetic News and Research

Researchers identify novel protein that explains how biological clocks regulate human sleep

Researchers identify two novel genes associated with development of rare, aggressive blood cancer

Scientists discover gene variation that makes humans have healthier blood lipid levels, reduced risk of heart attacks

Researchers use computer-aided design tool to create genetic languages of biological systems

CNIO scientist wins 2014 Stewart Rahr-PCF Young Investigator Award from Prostate Cancer Foundation

Japanese PAH patient prognosis ‘good’

SAGE Therapeutics announces completion of $38 million Series C financing

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

Study: Musical aptitude is affected by a combination of genes involved in auditory pathway

Microbial DNA may be involved in the development of autoimmune processes, shows study

Patients with congenital disorders are urged to register with CMDIR to advance clinical trials

Roy Castle Lung Cancer Foundation funds two new projects to support research into lung cancer

Blocking function of enzyme slows spread of pancreatic cancer, say researchers

N30 Pharma begins oral dosing in N91115 Phase 1 trial for treatment of cystic fibrosis

Three innovative tools to detect, test and initiate personalized drug treatment for seizures

Researchers explore how genetics affects causes and prevalence of preterm birth

Cancer doctors push for payment changes

Study finds link between elevated urinary Gb3 and heart disease

Compensatory brain mechanisms at play in siblings of bipolar patients

Researchers discover two new gene regions connected to bipolar disorder

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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