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CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

New research led by Le Cong of Stanford University School of Medicine in California indicates that the KCNA6 potassium channel may help with viral entry and promote infection. In addition, KCNA6 is highly expressed in OLIG2+ neuronal cells, which has been shown to be suspectable to SARS-CoV-2 in the olfactory neuroepithelium. This area appears to contribute to loss of smell commonly observed during infection.

6 Jul 2021

Antibiotic clofoctol shows potential against SARS-CoV-2

In a recent study, a group of French researchers aimed to reduce the regulatory preclinical development steps that potential candidates are normally subjected to.

5 Jul 2021

New study attempts to characterize long-COVID in all its complexity

In a new meta-study, a large subset of reports on post-viral complications in individuals following a SARS-CoV-2 infection have been organized and categorized, mapping 287 unique clinical findings related to long-COVID.

5 Jul 2021

Exposure to beneficial microorganisms is not affected by targeted hygiene or cleaning

The theory that modern society is too clean, leading to defective immune systems in children, should be swept under the carpet, according to a new study by researchers at UCL and the London School of Hygiene & Tropical Medicine.

5 Jul 2021

Research pinpoints a molecular component responsible for modulating flu damage

New experimental data pinpoints a molecular component responsible for modulating the damage the flu can wreck on the lungs.

2 Jul 2021

Study demonstrates successful postinfection treatment for SARS-CoV-2

A recent study by Kansas State University virologists demonstrates successful postinfection treatment for SARS-CoV-2, the virus that causes COVID-19.

2 Jul 2021

The use of flavonoids as antiviral agents against SARS-CoV-2

Researchers in Iran have undertaken a comprehensive review of flavonoids and their antiviral potential against SARS-CoV-2.

2 Jul 2021

Study: Valvular heart disease in patients with chronic heart failure has been underestimated

Hitherto, the development of valvular heart disease in patients with chronic heart failure has been underestimated and rarely treated.

1 Jul 2021

Scientists uncover features of T cells that distinguish fatal COVID-19 from non-fatal cases

While vaccines are doing a remarkable job of slowing the COVID-19 pandemic, infected people can still die from severe illness and new medications to treat them have been slow to arise.

1 Jul 2021

New software tool can help identify gene regulators more efficiently

A team of scientists at the University of Illinois Chicago has developed a software tool that can help researchers more efficiently identify the regulators of genes. The system leverages a machine learning algorithm to predict which transcription factors are most likely to be active in individual cells.

1 Jul 2021

First demonstration of COVID-19-like response by an essential virus encoded protein by SARS-CoV-2 in vivo

Researchers from collaborating universities in Virginia have recently utilized transgenic mice to explore the effects of SARS-CoV-2 on associated lung injury.

30 Jun 2021

Novel surgical technique shows promise to repair ruptures caused by heart attacks

Heart attack, medically known as myocardial infarction (MI), is a common heart condition. MI is caused by problems in blood supply to parts of the heart.

30 Jun 2021

Intranasal COVID-19 vaccine developed from bacterial extracellular vesicle induces robust antibody response in preclinical trials

A team of US-based scientists recently developed a novel vaccine candidate against SARS-CoV-2, the causative pathogen of COVID-19. The vaccine is composed of extracellular vesicles of Salmonella typhimurium incorporated with the spike receptor-binding domain (RBD) of SARS-CoV-2. Upon intranasal administration in hamsters, the vaccine induces strong blood antibody titers and protects against severe COVID-19.

30 Jun 2021

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

Using real-time deformability cytometry, researchers at the Max-Planck-Zentrum für Physik und Medizin in Erlangen were able to show for the first time: Covid-19 significantly changes the size and stiffness of red and white blood cells - sometimes over months.

29 Jun 2021

Study reveals public health risks posed by household fireworks

Fireworks are synonymous in the United States with the celebration of Independence Day and other special events, but the colorful displays have caused a growing risk to public safety in recent years, according to a study by environmental health researchers at the University of California, Irvine.

29 Jun 2021

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Researchers have found that the y cross-chain structure of fibrin proteins is essential to stabilizing blood clots that can lead to harmful embolism formation.

29 Jun 2021

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

Researchers from Canada recently presented an efficient strategy for recombinant production of enzymatically active TMPRSS2 ectodomain, enabling enzymatic characterization and the 1.95 Å X-ray crystal structure. Their work is published on the bioRxiv* preprint server while awaiting peer-review.

29 Jun 2021

New spider web mechanism kills pathogens and virus responsible for COVID-19

Immunologists at McMaster University have discovered a previously unknown mechanism which acts like a spider web, trapping and killing pathogens such as influenza or SARS-CoV-2, the virus responsible for COVID-19.

29 Jun 2021

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Scientists from the Netherlands and the US recently studied the localization of the SARS-CoV-2 proteins in postmortem lung tissues of COVID-19 patients and in SARS-CoV-2 infected Vero cells that were processed identically. The research is posted to the bioRxiv* preprint server, prior to peer review.

29 Jun 2021

Aerosol generated by playing wind instruments is less than that produced when vocalizing

Aerosol generated by playing woodwind and brass instruments is less than that produced when vocalizing (speaking and singing) and is no different than a person breathing, new research has found.

29 Jun 2021

Lungs News and Research

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Antibiotic clofoctol shows potential against SARS-CoV-2

New study attempts to characterize long-COVID in all its complexity

Exposure to beneficial microorganisms is not affected by targeted hygiene or cleaning

Research pinpoints a molecular component responsible for modulating flu damage

Study demonstrates successful postinfection treatment for SARS-CoV-2

The use of flavonoids as antiviral agents against SARS-CoV-2

Study: Valvular heart disease in patients with chronic heart failure has been underestimated

Scientists uncover features of T cells that distinguish fatal COVID-19 from non-fatal cases

New software tool can help identify gene regulators more efficiently

First demonstration of COVID-19-like response by an essential virus encoded protein by SARS-CoV-2 in vivo

Novel surgical technique shows promise to repair ruptures caused by heart attacks

Intranasal COVID-19 vaccine developed from bacterial extracellular vesicle induces robust antibody response in preclinical trials

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

Study reveals public health risks posed by household fireworks

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

New spider web mechanism kills pathogens and virus responsible for COVID-19

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Aerosol generated by playing wind instruments is less than that produced when vocalizing

The ultimate guide to lung research tools and protocols eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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