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Research reveals genomic basis of acute erythroid leukemia

Acute erythroid leukemia is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children's Research Hospital that appears today in the journal Nature Genetics.

30 Mar 2019

IASLC 2019 Small Cell Lung Cancer Meeting focuses on immunotherapy and patient perspective

While non-small cell lung cancer is the more common form of lung cancer and attracts the lion's share of the research funding, recent developments in small cell lung cancer may be shifting that slightly.

29 Mar 2019

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor.

28 Mar 2019

Research Recognition Award will help improve lives of young people with absence epilepsy

The 2019 Epilepsy League Research Recognition Award and prize money of CHF 25,000 is set to benefit young people: Dr. phil. Martina Hubacher is researching “The absent mind – Neurocognition and sleep in young people with absence seizures” at the University Children's Hospital Basel.

25 Mar 2019

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report.

25 Mar 2019

Exposure to dim light at night may contribute to spread of breast cancer to bones

Exposure to dim light at night, which is common in today's lifestyle, may contribute to the spread of breast cancer to the bones, researchers have shown for the first time in an animal study.

25 Mar 2019

Altering gut microbiome may be potential treatment option for PCOS

Symptoms of polycystic ovary syndrome improved with exposure to healthy bacteria in the gut, according to a study in a mouse model of this common women's endocrine disorder.

25 Mar 2019

Nervous system relies on guidance cues for neuronal axons to reach destinations

Similar to the dozens of Sherpas that guide hikers up treacherous Himalayan mountains to reach a summit, the nervous system relies on elaborate timing and location of guidance cues for neuronal axons--threadlike projections--to successfully reach their destinations in the body.

25 Mar 2019

City of Hope exhibits current studies and data on cancer therapies at AACR

City of Hope, a world-renowned independent research and treatment center for cancer and diabetes, will showcase ongoing studies and data on chimeric antigen receptor T cell therapy, immunotherapy against solid tumors and more at the American Association for Cancer Research annual meeting from March 29 through April 3 in Atlanta.

22 Mar 2019

Enzyme inhibitor stops inflammation and neurodevelopmental disorders in mouse models

Work published this week in the journal Proceedings of the National Academy of Sciences shows that an enzyme inhibitor developed by Professor Bruce Hammock and colleagues at UC Davis reduced inflammation in the brains of mice born to mothers with maternal immune activation.

20 Mar 2019

Cholesterol lowering drug can also help treat cancer-associated cachexia

Brazilian researchers have discovered that a drug regularly prescribed to control cholesterol can also be used to treat cachexia, or wasting syndrome, a condition characterized by rapid weight loss and muscle atrophy associated with extreme physical weakness.

19 Mar 2019

GARP protein can be a potential target for immunotherapy against colorectal cancer

Colorectal cancer is the third leading cause of cancer-related deaths in both men and women. Despite significant advances in therapies for this particular cancer, the five-year survival rate is 12 percent, according to the American Cancer Society.

19 Mar 2019

Compounds found in coffee may inhibit growth of prostate cancer

For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans.

18 Mar 2019

Exosomes are key to SOS signal that the heart muscle sends out after heart attack, study reveals

Human cells shed exosomes. These tiny extracellular, membrane-bound vesicles can carry cargo for cell-to-cell communication, ferrying diverse loads of proteins, lipids or nucleic acids.

14 Mar 2019

Study suggests new approach to ameliorating obesity-associated metabolic abnormalities

The search by scientists to find ways to combat obesity continues. Recently, investigators have been exploring whether they can engage the lymphatic system to help regulate obesity-induced inflammation of fat (adipose) tissue and restore systemic metabolic fitness.

14 Mar 2019

Increased stress hormones accelerate breast cancer metastasis

It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones.

14 Mar 2019

Researchers define pathway that helps us make antibodies

Our bodies are continuously concocting specific antibodies to thwart invaders like a virus or even pollen, and scientists have new information about how the essential production gets fired up and keeps up.

13 Mar 2019

Avocado seed extract could be potential source for novel anti-inflammatory compounds

An extract from the seeds of avocados exhibited anti-inflammatory properties in a laboratory study, according to Penn State researchers, and it represents a potential source for novel anti-inflammatory compounds that could be developed as a functional food ingredient or pharmaceuticals.

13 Mar 2019

Researchers identify potential therapeutic target for blocking early atherosclerosis in progeria

Researchers at the Centro Nacional de Investigaciones Cardiovasculares and the Universidad de Oviedo have discovered a new molecular mechanism involved in the premature development of atherosclerosis in mice with Hutchinson-Gilford progeria syndrome.

12 Mar 2019

CMV airway infection enlarges spectrum of environmental allergens

Cytomegalovirus infection can convert a harmless, inhaled protein antigen into an allergen, according to a study published March 7 in the open-access journal PLOS Pathogens by Rafaela Holtappels from the University Medical Center of the Johannes Gutenberg-University Mainz, and colleagues.

8 Mar 2019

Mouse Model News and Research

Research reveals genomic basis of acute erythroid leukemia

IASLC 2019 Small Cell Lung Cancer Meeting focuses on immunotherapy and patient perspective

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

Research Recognition Award will help improve lives of young people with absence epilepsy

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

Exposure to dim light at night may contribute to spread of breast cancer to bones

Altering gut microbiome may be potential treatment option for PCOS

Nervous system relies on guidance cues for neuronal axons to reach destinations

City of Hope exhibits current studies and data on cancer therapies at AACR

Enzyme inhibitor stops inflammation and neurodevelopmental disorders in mouse models

Cholesterol lowering drug can also help treat cancer-associated cachexia

GARP protein can be a potential target for immunotherapy against colorectal cancer

Compounds found in coffee may inhibit growth of prostate cancer

Exosomes are key to SOS signal that the heart muscle sends out after heart attack, study reveals

Study suggests new approach to ameliorating obesity-associated metabolic abnormalities

Increased stress hormones accelerate breast cancer metastasis

Researchers define pathway that helps us make antibodies

Avocado seed extract could be potential source for novel anti-inflammatory compounds

Researchers identify potential therapeutic target for blocking early atherosclerosis in progeria

CMV airway infection enlarges spectrum of environmental allergens

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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