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European Commission grants orphan drug designation to SGX301 for treatment of CTCL

Soligenix, Inc., a late-stage biopharmaceutical company developing products that address unmet medical needs in the areas of inflammation, oncology and biodefense, announced today that the European Commission, acting on the positive recommendation from the European Medicines Agency Committee for Orphan Medicinal Products (COMP), has granted orphan drug designation to synthetic hypericin (the active pharmaceutical ingredient in SGX301) for the treatment of cutaneous T-cell lymphoma (CTCL), a rare disease and a class of non-Hodgkin's lymphoma, a type of cancer of the white blood cells that are an integral part of the immune system.

4 Aug 2015

Oasmia announces topline results from head-to-head comparison study of Paclical and Abraxane

Oasmia Pharmaceutical AB, developer of a new generation of drugs within human and veterinary oncology, announced today the topline findings from a head-to-head comparison study of its lead human cancer product candidate Paclical and Celgene's Abraxane, which show similar pharmacokinetic (PK) profiles of the two products. The study was conducted in women with metastatic breast cancer.

4 Aug 2015

Cipher receives Acceptance Review Notification from FDA for 510(k) submission for Dermadexin

Cipher Pharmaceuticals Inc. today announced that it has received an Acceptance Review Notification for its 510(k) submission for Dermadexin to the U.S. Food & Drug Administration.

4 Aug 2015

Discovery could pave way for new drugs to treat people with memory problems

A team of scientists believe they have shown that memories are more robust than we thought and have identified the process in the brain, which could help rescue lost memories or bury bad memories, and pave the way for new drugs and treatment for people with memory problems.

4 Aug 2015

3D printed brain tissue could help fight brain disorders

The brain is amazingly complex, with around 86 billion nerve cells. The challenge for researchers to create bench-top brain tissue from which they can learn about how the brain functions, is an extremely difficult one.

4 Aug 2015

Breakthroughs against Plasmodium falciparum pave way for latest advancement

When the highly-influential European Medicines Agency announced its recommendation to approve what could be the world's first licensed vaccine against malaria in infants and children, there was much celebrating in the research community at NYU Langone Medical Center.

4 Aug 2015

Researchers awarded NIH grant to revolutionize TB treatment

Stop Jeff North, Ph.D., if you've heard this one before: an indole-based drug and a tuberculosis protein meet in a laboratory. There's a brief interaction, then the drug skates merrily away while the protein is nowhere to be found.

4 Aug 2015

Study provides mechanism for EDNRB gene's role in adaptation to life at high altitudes

Ethiopians have lived at high altitudes for thousands of years, providing a natural experiment for studying human adaptations to low oxygen, a condition known as hypoxia. One factor that may enable Ethiopians to tolerate high altitudes and hypoxia is the endothelin receptor type B (EDNRB) gene.

4 Aug 2015

Benefits and risks of taking antidepressant medications during pregnancy

Treating maternal psychiatric disorder with commonly used antidepressants is associated with a lower risk of certain pregnancy complications including preterm birth and delivery by Caesarean section, according to researchers at Columbia University's Mailman School of Public Health, Columbia University Medical Center, and the New York State Psychiatric Institute. However, the medications -- selective serotonin reuptake inhibitors, or SSRIs -- resulted in an increased risk of neonatal problems.

4 Aug 2015

People with chronic insomnia may be able to get relief from half of standard sleeping pills

The roughly nine million Americans who rely on prescription sleeping pills to treat chronic insomnia may be able to get relief from as little as half of the drugs, and may even be helped by taking placebos in the treatment plan, according to new research published today in the journal Sleep Medicine by researchers from the Perelman School of Medicine at the University of Pennsylvania.

4 Aug 2015

Research finding could help reveal how the human brain learns complex motor skills

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. To learn and improve, the songbird brain needs to shake up its tried-and-true patterns with a healthy dose of creative experimentation. Until now, no one has found a specific mechanism by which this could occur.

4 Aug 2015

New ACMG Scope of Practice of the Specialty of Medical Genetics document released

The field of medical genetics is swiftly evolving. It's a period of rapid scientific discovery, new technologies and subsequent translation into medical practice, public policy and public health. But what role should the Medical Genetics specialist have since genetics impacts all patients and specialties in some way? In an effort to clearly define the changing role of the specialty of Medical Genetics and the distinction between Medical Geneticists and other genetics healthcare professionals, the American College of Medical Genetics and Genomics has has just released a new "Scope of Practice of the Specialty of Medical Genetics" document, revising its earlier 2008 Policy Statement.

4 Aug 2015

Northwestern gets $17.5 million NIH grant to invent, develop implantable drug delivery system for HIV prevention

Northwestern Medicine scientists have received a five-year, $17.5 million grant from the National Institutes of Health for an interdisciplinary project that aims to invent, develop and test an implantable drug delivery system to protect high-risk individuals from HIV infection for up to a year at a time.

4 Aug 2015

BrightFocus announces recipients of 2015 research program grants

BrightFocus Foundation, which funds research worldwide on Alzheimer's disease, glaucoma, and macular degeneration, today announced that its 2015 research program grants have been awarded to 58 scientists in 20 states and 7 foreign countries. Part of an $11 million research investment, the grants reflect the largest annual research funding in the foundation's history.

4 Aug 2015

NYSCF scientists design new robotic platform to automate generation of patient-specific stem cells

Scientists at The New York Stem Cell Foundation Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells.

4 Aug 2015

Stress responder plays critical, early step in repairing DNA damage

DNA damage increases the risk of cancer, and researchers have found that a protein, known to rally when cells get stressed, plays a critical, early step in its repair.

4 Aug 2015

New Tel Aviv University study sheds light on precise trigger of deadly melanoma

Skin cancer is the most common of all cancers, and melanoma, which accounts for 2% of skin cancer cases, is responsible for nearly all skin cancer deaths. Melanoma rates in the US have been rising rapidly over the last 30 years, and although scientists have managed to identify key risk factors, melanoma's modus operandi has eluded the world of medical research.

4 Aug 2015

Pitt investigators to lead $5 million initiative to monitor resistance to HIV prevention drugs in sub-Saharan Africa

Infectious diseases researchers from the University of Pittsburgh School of Medicine are leading a five-year, $5 million initiative to monitor drug resistance during the rollout of HIV prevention drugs in sub-Saharan Africa.

4 Aug 2015

First biodegradable gene delivery system efficiently penetrates human airway mucus barrier of lung tissue

Researchers at the Johns Hopkins University School of Medicine, Johns Hopkins University Department of Chemical and Biomolecular Engineering, and Federal University of Rio de Janeiro in Brazil have designed a DNA-loaded nanoparticle that can pass through the mucus barrier covering conducting airways of lung tissue — proving the concept, they say, that therapeutic genes may one day be delivered directly to the lungs to the levels sufficient to treat cystic fibrosis (CF), chronic obstructive pulmonary disease, asthma and other life-threatening lung diseases.

4 Aug 2015

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery.

4 Aug 2015

Drugs News and Research

European Commission grants orphan drug designation to SGX301 for treatment of CTCL

Oasmia announces topline results from head-to-head comparison study of Paclical and Abraxane

Cipher receives Acceptance Review Notification from FDA for 510(k) submission for Dermadexin

Discovery could pave way for new drugs to treat people with memory problems

3D printed brain tissue could help fight brain disorders

Breakthroughs against Plasmodium falciparum pave way for latest advancement

Researchers awarded NIH grant to revolutionize TB treatment

Study provides mechanism for EDNRB gene's role in adaptation to life at high altitudes

Benefits and risks of taking antidepressant medications during pregnancy

People with chronic insomnia may be able to get relief from half of standard sleeping pills

Research finding could help reveal how the human brain learns complex motor skills

New ACMG Scope of Practice of the Specialty of Medical Genetics document released

Northwestern gets $17.5 million NIH grant to invent, develop implantable drug delivery system for HIV prevention

BrightFocus announces recipients of 2015 research program grants

NYSCF scientists design new robotic platform to automate generation of patient-specific stem cells

Stress responder plays critical, early step in repairing DNA damage

New Tel Aviv University study sheds light on precise trigger of deadly melanoma

Pitt investigators to lead $5 million initiative to monitor resistance to HIV prevention drugs in sub-Saharan Africa

First biodegradable gene delivery system efficiently penetrates human airway mucus barrier of lung tissue

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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