Protein C News and Research

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Person's age, mobility could be powerful predictors of survival than certain biomarkers

Advances in technology allow scientists to measure intricate details about the human body that greatly enhance understanding of health, disease and aging.

7 Apr 2016

Carbohydrate-binding protein controls inflammation in osteoarthritis patients

More and more people, particularly older people, are suffering from osteoarthritis due to wear and tear on their joints. This primarily affects the knee and hip joints but also the spine. In earlier studies, scientists at MedUni Vienna Department of Orthopaedics showed that raised levels of certain proteins, so-called galectins, and their docking sites are found in patients with osteoarthritis.

7 Apr 2016

SCIEX and QPS Holdings enter collaboration to establish the BioBA solution for bioanalysis of biologics

SCIEX, a global leader in life science analytical technologies, and QPS Holdings, LLC (QPS), a leading global full-service Contract Research Organization (CRO), today announced a collaboration to advance Hybrid LBA –LCMS, a workflow for routine biologics quantification. Under the agreement, QPS Holdings will deploy the SCIEX BioBA Solution, the first end-to-end and most complete solution for bioanalysis of biologics.

6 Apr 2016

Blocking of LIPG activity could arrest breast cancer growth

In an article published in Nature Communications, the researchers report that breast cancer cells need to take up lipids from the extracellular environment in order to continue proliferating.

6 Apr 2016

Researchers identify possible genetic basis for coronary artery disease

For many people, coronary artery disease, or CAD—the buildup of plaque in the heart's arteries—is an unfortunate part of aging. By studying the genetic makeup of those who manage to maintain clear arteries into old age, researchers have identified a possible genetic basis for the disease, as well as potential new opportunities to prevent it.

6 Apr 2016

Innovative nano-therapy treatment can fight chronic inflammatory disorders, cancer

For an innovative treatment, which allows to selectively direct nanoparticles of iron oxide into cell targets in the blood to fight chronic inflammatory disorders or cancer that was successfully tested in a cell culture and animal models, Dr. Andrea de Vizcaya Ruiz, was awarded with the Innovation Award in Bionanotechnology Cinvestav-Neolpharma 2015.

6 Apr 2016

New study shows link between FZD7 protein and breast cancer development

A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of which play key roles in mammary gland formation and breast cancer development.

6 Apr 2016

High-quality protein foods could be beneficial for obese people looking to reduce weight

New research published in the Journal of Gerontology: Medical Sciences shows that eating more protein from foods like lean beef, as part of a reduced-calorie diet, can help obese older adults with limited ability to exercise to lose weight and increase physical function. This new research, supported by the Beef Checkoff, contributes to the growing body of evidence that shows lean beef and other high-quality protein foods are beneficial for health, including overweight and obese people looking to reduce weight.

5 Apr 2016

Liraglutide drug makes highly desirable foods less appealing to people

Understanding the motivations that drive humans to eat is an important consideration in the development of weight loss therapies. Now a study led by researchers at Beth Israel Deaconess Medical Center helps explain how the diabetes and weight loss drug liraglutide acts on brain receptors to make enticing foods seems less desirable.

5 Apr 2016

Artificial mimic of protein could lead to new ways of building light-sensitive artificial cells

An artificial mimic of a key light-sensitive molecule has been made by scientists at the University of Bristol. The work, published in Science, could lead to new ways of building light-sensitive artificial cells.

5 Apr 2016

Losmapimod drug fails to meet primary endpoint in clinical trial

Patients taking losmapimod, an anti-inflammatory drug currently being developed, for 12 weeks following a heart attack did not show improvements in the trial's primary endpoint, the rate of cardiovascular death, subsequent heart attack or urgent coronary revascularization, which includes placement of a stent or coronary artery bypass surgery, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

5 Apr 2016

Maternal smoking influences epigenetic programming of unborn child's genetic make-up

If mothers smoke during pregnancy, they influence the epigenetic programming of their unborn child's genetic make-up in the long term. This may give rise to an increased risk of the development of disease risks later in the child's life.

5 Apr 2016

Pediatric researchers uncover new syndrome that causes intellectual disability

Pediatric researchers, using high-speed DNA sequencing tools, have identified a new syndrome that causes intellectual disability (ID). Drawing on knowledge of the causative gene mutation, the scientists' cell studies suggest that an amino acid supplement may offer a targeted treatment for children with this condition.

5 Apr 2016

Aged tumor cells in melanoma behave in a different way than younger tumor cells

Cancer risk increases with one's age as accumulated damage to our cells and chronic inflammation occur over time. Now, an international team of scientists led by The Wistar Institute have shown that aged tumor cells in melanoma behave differently than younger tumor cells, according to study results published in the journal Nature.

5 Apr 2016

Scientists successfully turn off misbehaving protein that fuels growth of triple-negative breast cancer

Working with human breast cancer cells, a team of scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have successfully turned off a misbehaving protein that fuels the growth of a particularly aggressive, drug-resistant form of the disease known as triple-negative breast cancer.

5 Apr 2016

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Little is known about the molecular basis of aberrant protein glycosylation, a complex enzymatic process that is a hallmark of many human cancers including colorectal cancers (CRC), and how it may contribute to tumor progression. In a new study published in Scientific Reports, an online journal of the Nature Publishing Group, scientists at Case Western Reserve University School of Medicine have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

4 Apr 2016

Cambridge Pharmaceutical Cryo-EM Consortium formed by FEI, five pharmaceutical companies, the Medical Research Council and the University of Cambridge

FEI (NASDAQ: FEIC) has partnered with five pharmaceutical companies: Astex Pharmaceuticals, AstraZeneca, GlaxoSmithKline, Heptares Therapeutics, and UCB; the Medical Research Council Laboratory of Molecular Biology (MRC-LMB); and the University of Cambridge’s Nanoscience Centre, to form the “Cambridge Pharmaceutical Cryo-EM Consortium,” which is the first of its kind worldwide.

From Thermo Fisher Scientific – Electron Microscopy Solutions 4 Apr 2016

Protein C News and Research

Person's age, mobility could be powerful predictors of survival than certain biomarkers

Carbohydrate-binding protein controls inflammation in osteoarthritis patients

SCIEX and QPS Holdings enter collaboration to establish the BioBA solution for bioanalysis of biologics

Blocking of LIPG activity could arrest breast cancer growth

Researchers identify possible genetic basis for coronary artery disease

Innovative nano-therapy treatment can fight chronic inflammatory disorders, cancer

New study shows link between FZD7 protein and breast cancer development

High-quality protein foods could be beneficial for obese people looking to reduce weight

Liraglutide drug makes highly desirable foods less appealing to people

Artificial mimic of protein could lead to new ways of building light-sensitive artificial cells

Losmapimod drug fails to meet primary endpoint in clinical trial

Maternal smoking influences epigenetic programming of unborn child's genetic make-up

Pediatric researchers uncover new syndrome that causes intellectual disability

Aged tumor cells in melanoma behave in a different way than younger tumor cells

Scientists successfully turn off misbehaving protein that fuels growth of triple-negative breast cancer

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Cambridge Pharmaceutical Cryo-EM Consortium formed by FEI, five pharmaceutical companies, the Medical Research Council and the University of Cambridge

Liu Laboratory at Augusta University studies exosomes using Particle Metrix’s ZetaView

One in 10 people in UK believed to be vitamin B12 deficient

Heart disease patients who experience mental stress ischemia tend to have higher levels of troponin

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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