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Identical twins shine new light on genetic cause of juvenile arthritis

Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease.

24 Jan 2019

Study sheds new light on male infertility

Hope has emerged for infertile men as scientists at Newcastle University have understood the importance of a gene in regulating the production of fully-functioning sperm.

24 Jan 2019

Myelin-producing cells are altered in multiple sclerosis, shows study

Subpopulations of oligodendrocytes, myelin-producing cells in the brain that are targeted by the immune system in multiple sclerosis (MS), are altered in MS and might therefore have additional roles in the disease than previously described.

23 Jan 2019

Scientists discover new blood vessels in bone

Researchers have discovered new blood vessels in the long bones of mice and similar new vessels in human long bones that could be used to further our understanding of osteoporosis.

23 Jan 2019

Researchers gain new insights into development of necrotizing enterocolitis in preemies

Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, discovered a promising direction toward understanding the development of necrotizing enterocolitis, a devastating intestinal disease commonly affecting premature infants, in order to treat it.

23 Jan 2019

Researchers discover how body initiates repair mechanisms that limits damage to myelin sheath

Diseases such as multiple sclerosis are characterized by damage to the 'myelin sheath', a protective covering wrapped around nerve cells akin to insulation around an electrical wire.

22 Jan 2019

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Using a new epigenetics-based approach, scientists have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease.

22 Jan 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

Study: Male and female differences in fear memory is attributed to Cdk5 gene

In a mouse model of traumatic memory, male mice recall fear-related memories better than female mice, according to a study in Biological Psychiatry. The difference between sexes was attributed to a gene important for creating fear memories and stress behavior, called cyclin dependent kinase 5, which was naturally activated in male but not in female mice.

18 Jan 2019

Rutgers study finds gene responsible for spread of prostate cancer

A Rutgers study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer.

17 Jan 2019

Research reveals novel approach to suppressing chemotherapy-induced tumor growth

Following up on a groundbreaking 2018 study in which BIDMC's Dipak Panigrahy, MD, demonstrated that dead and dying cancer cells killed by conventional cancer treatments paradoxically trigger inflammation that promotes tumor growth and metastasis, a new study led by Allison Gartung, PhD, describes a novel approach to suppressing chemotherapy-induced tumor growth in an ovarian cancer model.

16 Jan 2019

TGF-beta signaling pathway in uterine cells protects against cancer

Two new mouse models of uterine cancer shed light on how this disease - the most common gynecological cancer in the U.S. - happens.

16 Jan 2019

FDA-approved drug hampers cancer metastasis in animal model, shows study

For cancer to spread, it needs a hospitable environment in distant organs. This fertile "soil" can provide a home to circulating malignant cells.

16 Jan 2019

Researchers manipulate T cells to improve transplant success

Researchers have manipulated T cells in a way that prevents the rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection.

15 Jan 2019

Viral replication not necessary to cause lethal disease by food-borne pathogen

The replication of a bacterial virus is not necessary to cause lethal disease in a mouse model of a food-borne pathogen called Enterohemorrhagic Escherichia coli, according to a study published January 10 in the open-access journal PLOS Pathogens by Sowmya Balasubramanian, John Leong and Marcia Osburne of Tufts University School of Medicine, and colleagues.

10 Jan 2019

Mechanism underlying impaired allergic inflammation in children may explain hygiene hypothesis

The hygiene hypothesis may explain why asthma and other allergic airway diseases have dramatically increased over the past decades in industrialized countries.

9 Jan 2019

Long-term postpartum obesity may be due to reprogramming of maternal energy metabolism

During normal pregnancy, mothers always gain body weight within a proper range. However, many women worry that extra pounds put on during pregnancy will not be lost after childbirth and, in fact, past studies have shown that excessive gestational weight gain is associated with immediate postpartum weight retention.

9 Jan 2019

Mouse Model News and Research

Identical twins shine new light on genetic cause of juvenile arthritis

Study sheds new light on male infertility

Myelin-producing cells are altered in multiple sclerosis, shows study

Scientists discover new blood vessels in bone

Researchers gain new insights into development of necrotizing enterocolitis in preemies

Researchers discover how body initiates repair mechanisms that limits damage to myelin sheath

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Study: Male and female differences in fear memory is attributed to Cdk5 gene

Rutgers study finds gene responsible for spread of prostate cancer

Research reveals novel approach to suppressing chemotherapy-induced tumor growth

TGF-beta signaling pathway in uterine cells protects against cancer

FDA-approved drug hampers cancer metastasis in animal model, shows study

Researchers manipulate T cells to improve transplant success

Viral replication not necessary to cause lethal disease by food-borne pathogen

Mechanism underlying impaired allergic inflammation in children may explain hygiene hypothesis

Long-term postpartum obesity may be due to reprogramming of maternal energy metabolism

Researchers identify and overcome barrier in CRISPR gene editing to treat muscular dystrophy

Essential nutrient may hold promise in the war against Alzheimer's disease

First viable mouse model of Hirschsprung's disease developed

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