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Doctors advise against off-label use of new Alzheimer's medicine for cerebral amyloid angiopathy

A novel therapy recently approved by the U.S. Food and Drug Administration for patients with Alzheimer's disease amid considerable controversy should not be prescribed by physicians off-label for cerebral amyloid angiopathy (CAA), a similar cerebrovascular condition, according to Steven Greenberg, MD, PhD, director of the Hemorrhagic Stroke Research Program at Massachusetts General Hospital (MGH) and president of the International Cerebral Amyloid Angiopathy Association (ICAAA).

7 Jul 2021

New discovery provides clues to elucidate the pathogenesis of muscle diseases

A research collaboration based in Kumamoto University, Japan has discovered that muscles and the resident stem cells (satellite cells) responsible for muscle regeneration retain memory of their location in the body.

6 Jul 2021

NYUAD researchers unlock an epigenetic code that allows liver regeneration

NYU Abu Dhabi researchers uncovered a code that sets the genome of the liver to account for the remarkable ability for this organ to regenerate.

6 Jul 2021

Long-term exposure to air pollutants increases the risk of dysmenorrhea in women

Dysmenorrhea, that is, frequent severe and painful cramps during menstruation from abnormal contractions of the uterus, is the most common of all gynecological disorders. It affects between 16-91% of girls and women of reproductive age, of whom 2%-29% have symptoms severe enough to restrict their daily activity.

6 Jul 2021

Study explores the effects of consecutive sleep loss on daily well-being

All it takes is three consecutive nights of sleep loss to cause your mental and physical well-being to greatly deteriorate.

6 Jul 2021

Digital technologies amplify the ability to detect subtle differences in cognitive function tests

During neuropsychological assessments, participants complete tasks designed to study memory and thinking. Based on their performance, the participants receive a score that researchers use to evaluate how well specific domains of their cognition are functioning.

6 Jul 2021

Study: TBI doesn't necessarily lead to an increased risk of marital instability

Traumatic brain injury (TBI) has a major impact on the lives of affected patients and families. But it doesn't necessarily lead to an increased risk of marital instability, as two-thirds of patients with TBI are still married to the same partner 10 years after their injury, reports a study in the July/August issue of the Journal of Head Trauma Rehabilitation.

6 Jul 2021

Fecal transplant and fiber supplementation can benefit patients with obesity-related metabolic syndrome

A transplant of healthy gut microbes followed by fiber supplements benefits patients with severe obesity and metabolic syndrome, according to University of Alberta clinical trial findings published today in Nature Medicine.

6 Jul 2021

Lower UVB exposure correlated with higher risk of colorectal cancer

University of California San Diego School of Medicine researchers have identified a possible link between inadequate exposure to ultraviolet-B (UVB) light from the sun and an increased risk of colorectal cancer, especially as people age.

6 Jul 2021

Simple blood tests may help prevent inaccuracy in the diagnosis of severe malaria

Using simple blood tests could help researchers identify children who have been misidentified as having severe malaria, according to a study published today in eLife.

6 Jul 2021

Princess Máxima Center and German top centers embark on childhood cancer research collaboration

The Princess Máxima Center for pediatric oncology is to embark on a close collaboration with German top centers in Heidelberg in the field of childhood cancer research.

6 Jul 2021

A new method for generating metabolic profiles of single cells

Scientists from the European Molecular Biology Laboratory and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells.

6 Jul 2021

Deletion of an embryonic gene in liver cells completely wipes out bile ducts of newborn mice

Scientists from the University of Pittsburgh School of Medicine described a new phenomenon in which the deletion of a single gene involved in liver embryogenesis completely wipes out bile ducts of newborn mice.

6 Jul 2021

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

New research evaluating the drugs commonly used by rheumatoid arthritis patients suggests two combinations could reduce the risk of heart attack and strokes.

6 Jul 2021

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

Scientists at UC San Francisco have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases, potentially paving the way for developing less expensive cellular therapies to treat diseases for which there are currently few viable options.

6 Jul 2021

New method expands view into activity of single cells

Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells. It's a big leap in the effort to understand cancer development, brain function, immunity and other biological processes driven by the complex interactions of multitudes of different cell types.

6 Jul 2021

Mutations in the Epsilon variant contribute to SARS-CoV-2 immune evasion

Three mutations in the Epsilon coronavirus spike protein dampen the neutralizing potency of antibodies induced by current vaccines or past COVID infections.

6 Jul 2021

Rural ambulance services are in jeopardy as volunteers age and expenses mount

Vern Greyn was standing in the raised bucket of a tractor, trimming dead branches off a tree, when he lost his balance. He fell 12 feet and struck his head on the concrete patio outside his house in this small farming town on the central Montana plains.

6 Jul 2021

School-based mindfulness improves sleep quality in children

A new study exploring the benefits of mindfulness showed that children slept 74 minutes more on average after starting basic mindfulness exercises at school.

6 Jul 2021

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

New research led by Le Cong of Stanford University School of Medicine in California indicates that the KCNA6 potassium channel may help with viral entry and promote infection. In addition, KCNA6 is highly expressed in OLIG2+ neuronal cells, which has been shown to be suspectable to SARS-CoV-2 in the olfactory neuroepithelium. This area appears to contribute to loss of smell commonly observed during infection.

6 Jul 2021

Medicine News and Research

Doctors advise against off-label use of new Alzheimer's medicine for cerebral amyloid angiopathy

New discovery provides clues to elucidate the pathogenesis of muscle diseases

NYUAD researchers unlock an epigenetic code that allows liver regeneration

Long-term exposure to air pollutants increases the risk of dysmenorrhea in women

Study explores the effects of consecutive sleep loss on daily well-being

Digital technologies amplify the ability to detect subtle differences in cognitive function tests

Study: TBI doesn't necessarily lead to an increased risk of marital instability

Fecal transplant and fiber supplementation can benefit patients with obesity-related metabolic syndrome

Lower UVB exposure correlated with higher risk of colorectal cancer

Simple blood tests may help prevent inaccuracy in the diagnosis of severe malaria

Princess Máxima Center and German top centers embark on childhood cancer research collaboration

A new method for generating metabolic profiles of single cells

Deletion of an embryonic gene in liver cells completely wipes out bile ducts of newborn mice

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

New method expands view into activity of single cells

Mutations in the Epsilon variant contribute to SARS-CoV-2 immune evasion

Rural ambulance services are in jeopardy as volunteers age and expenses mount

School-based mindfulness improves sleep quality in children

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Everything there is to know about biosimilars eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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