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Horizon, AstraZeneca partner to explore oncology-relevant genotypes to identify novel drug targets

Horizon Discovery and AstraZeneca have entered into a research, collaboration and license agreement to explore a range of oncology-relevant genotypes with the aim of identifying and validating a number of novel drug targets. This deal is the second collaboration between AstraZeneca and Horizon, and follows the announcement in April 2013 of an oncology discovery program to explore Horizon's first-in-class kinase target program, HD-001.

7 Jan 2014

Epizyme achieves POC milestone in EPZ-5676 DOT1L inhibitor clinical program

Epizyme, Inc., a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, today announced the achievement of the proof of concept milestone in the EPZ-5676 DOT1L inhibitor clinical program, earning a $25 million payment under the company's collaboration with Celgene Corporation.

7 Jan 2014

Researchers receive $540M from Ludwig Cancer Research to accelerate research on metastasis

Cancer researchers at the University of Chicago and five other leading institutions will share equally in a $540 million gift from Ludwig Cancer Research, on behalf of its founder Daniel K. Ludwig. Ludwig Cancer Research is an international community of researchers dedicated to pursuing life-changing discoveries to alter the course of cancer.

7 Jan 2014

USAMRMC to develop strategic research plan that identifies critical research priority areas in TBI

The U.S. Department of Defense funds more than 500 neurotrauma research projects totaling over $700 million. Yet there remains a large unmet medical need for effective treatments of traumatic brain injury (TBI), a major cause of disability and mortality.

6 Jan 2014

Adenosine deaminase has potential to improve prognosis, diagnosis and treatment of ESCC

Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore (NUS) have discovered a biomarker, called adenosine deaminase acting on RNA-1 (ADAR1), which has the potential to improve the diagnosis, prognosis and treatment of this disease.

6 Jan 2014

Johns Hopkins Kimmel Cancer Center scientists to receive $90M in new funding for cancer research

cientists at the Johns Hopkins Kimmel Cancer Center will receive $90 million in new funding as part of a $540 million gift from Ludwig Cancer Research, on behalf of its founder Daniel K. Ludwig, to six U.S. institutions. The new award is among the largest for a single private gift to cancer research.

6 Jan 2014

Editing of protein-making sequences promotes development of ESCC, find NUS researchers

Esophageal Squamous Cell Carcinoma, the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore have discovered a biomarker, called adenosine deaminase acting on RNA-1, which has the potential to improve the diagnosis, prognosis and treatment of this disease.

6 Jan 2014

Special publication details breakthrough research on causes of vascular disease

The world's leading voices in the fight against Pulmonary Hypertension have compiled a special publication detailing the breakthrough research into the causes of this debilitating vascular disease.

6 Jan 2014

Astellas, ClearPath announce strategic partnership to develop vaccine for infectious diseases

Astellas Pharma Inc. (Astellas) and ClearPath Development Company (ClearPath) announced today a strategic partnership to form a portfolio of development companies focused on vaccines targeting infectious diseases.

6 Jan 2014

Study uncovers how enzymes could be used to identify predisposition to ROS-related diseases

A UT Arlington chemist doing National Science Foundation-funded research on enzymes that regulate human biology has uncovered characteristics that could be used to identify predisposition to conditions such as heart disease, diabetic ulcers and some types of cancer.

6 Jan 2014

Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Scientists from the Florida campus of The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects—and reverse the disease.

6 Jan 2014

Gene-based technology for effective weight loss solutions

Losing weight is the most popular New Year's resolution for 2014, but research shows that only eight percent of people are successful in achieving their resolutions.

6 Jan 2014

Dysfunction in MADD gene in mice causes fasting hyperglycemia

Researchers from the University of Illinois at Chicago College of Medicine have found that dysfunction in a single gene in mice causes fasting hyperglycemia, one of the major symptoms of type 2 diabetes. Their findings were reported online in the journal Diabetes.

5 Jan 2014

AstraZeneca to take over Probiodrug's CDK9 inhibitor program

Probiodrug AG announced today the transfer of its experimental cyclin-dependent kinase 9 inhibitor program to AstraZeneca. The transaction includes the sale to AstraZeneca of a lead molecule and back-up compounds with the associated intellectual property. CDK9, which has been implicated in the transcriptional regulation of genes involved in proliferation and inflammation, is a promising target for the treatment of both cancer and inflammatory diseases.

3 Jan 2014

STSI researchers develop a small wireless device that detects abnormal, dangerous heart rhythms

Research by the Scripps Translational Science Institute (STSI) has found that a small adhesive wireless device worn on the chest for up to two weeks does a better job detecting abnormal and potentially dangerous heart rhythms than the Holter monitor, which is typically used for 24 hours and has been the standard of care for more than 50 years.

3 Jan 2014

Overweight minority women less aware of the increased risk of cardiovascular disease

Minority women tend to be less aware of the increased risk of cardiovascular disease they face by being overweight or obese. The results of a study that compared Hispanic and non-Hispanic white women based on their knowledge of heart disease risk factors and their perceptions of their own weight is published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.

3 Jan 2014

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Researchers from Huntsman Cancer Institute (HCI) at the University of Utah discovered a cellular mechanism that drives the spread of breast cancer to other parts of the body (metastasis), as well as a therapy which blocks that mechanism. The research results were published online in the journal Cell Reports on January 2.

3 Jan 2014

Study finds extraordinary link between narcolepsy and specific gene variant

A new study conducted across Europe found an extraordinary association between narcolepsy and a specific gene variant related to the immune system.

2 Jan 2014

Computer algorithm developed to identify genes that could be transformed to stop aging process

Restricting calorie consumption is one of the few proven ways to combat aging. Though the underlying mechanism is unknown, calorie restriction has been shown to prolong lifespan in yeast, worms, flies, monkeys, and, in some studies, humans.

2 Jan 2014

New research shows that as we age, the thermogenic activity of brown fat gets reduced

As most people resolve themselves to lose weight this New Year, here's why it seems to get easier and easier to pack on unwanted pounds: New research published in the January 2014 issue of The FASEB Journal, shows that as we age, the thermogenic activity of brown fat is reduced. Brown fat is a "good" fat located in the backs of our necks that helps burn "bad" white fat around our bellies. Additionally, the researchers also discovered a possible metabolic on/off switch that could reactivate brown fat.

2 Jan 2014

Genetic News and Research

Horizon, AstraZeneca partner to explore oncology-relevant genotypes to identify novel drug targets

Epizyme achieves POC milestone in EPZ-5676 DOT1L inhibitor clinical program

Researchers receive $540M from Ludwig Cancer Research to accelerate research on metastasis

USAMRMC to develop strategic research plan that identifies critical research priority areas in TBI

Adenosine deaminase has potential to improve prognosis, diagnosis and treatment of ESCC

Johns Hopkins Kimmel Cancer Center scientists to receive $90M in new funding for cancer research

Editing of protein-making sequences promotes development of ESCC, find NUS researchers

Special publication details breakthrough research on causes of vascular disease

Astellas, ClearPath announce strategic partnership to develop vaccine for infectious diseases

Study uncovers how enzymes could be used to identify predisposition to ROS-related diseases

Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Gene-based technology for effective weight loss solutions

Dysfunction in MADD gene in mice causes fasting hyperglycemia

AstraZeneca to take over Probiodrug's CDK9 inhibitor program

STSI researchers develop a small wireless device that detects abnormal, dangerous heart rhythms

Overweight minority women less aware of the increased risk of cardiovascular disease

University of Utah discovers cellular mechanism that stops metastasis of breast cancer

Study finds extraordinary link between narcolepsy and specific gene variant

Computer algorithm developed to identify genes that could be transformed to stop aging process

New research shows that as we age, the thermogenic activity of brown fat gets reduced

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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