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Mount Sinai study suggests significant role of reactive oxygen species in maintaining healthy intestines

Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.

3 Oct 2022

Can the gut be an alternative route for SARS-CoV-2 entry?

Researchers reviewed the gut pathophysiology of SARS-CoV-2 infection.

28 Sep 2022

Lab-grown ‘pigmented’ skin-equivalent commercially available for the first time

Labskin and University of Bradford team up to bring new science in skin health to greater diversity for skin types.

27 Sep 2022

SARS-CoV-2 generates amyloid in cerebral spinal fluid

In a recent study posted to the bioRxiv* preprint server, an international team of researchers demonstrated amyloid aggregation due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cerebrospinal fluid (CSF).

20 Sep 2022

Research reveals the role of microglia-neuron connections during brain development

The Laboratory of Neuroimmunology of the Institute of Experimental Medicine, Budapest, Hungary, led by Ádám Dénes, describes the presence of a direct interaction site between microglial cells and the cell body of developing neurons, and reveals its role during brain development.

20 Sep 2022

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Researchers explored the effect of SARS-CoV-2 exposure on the brain.

20 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* server, researchers in Singapore and the United States demonstrated that intranasal (I.N.) delivery of a mucosal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination triggered a superior T cell response compared to an equivalent dose of antigen delivered by the subcutaneous (S.C.) route.

12 Sep 2022

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial.

12 Sep 2022

Ultrasound color Doppler twinkling may aid the detection of breast biopsy markers

According to ARRS' American Journal of Roentgenology (AJR), ultrasound color Doppler twinkling may aid the detection of certain biopsy markers in metastatic axillary nodes that resume normal morphology after neoadjuvant systemic therapy.

8 Sep 2022

The role of some important antioxidants in major clinical outcomes of subjects with COVID-19

Researchers investigated the role of antioxidants such as selenium, zinc, α-lipoic acid, and vitamins A, E, D, and C in improving the clinical outcomes of COVID-19.

8 Sep 2022

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

How does origin impact antiviral immune response?

A new study observed differential antiviral responses in Indian and European individuals.

1 Sep 2022

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

Researchers investigated the role of the CD98 glycoprotein in inducing an inflammatory response to SARS-CoV-2 in patients of progressive fibrosis interstitial lung diseases, including the archetypal PFILD, idiopathic pulmonary fibrosis.

18 Aug 2022

Study contributes to better understanding of the changes in kinase activity in renal cell carcinoma

A new research paper was published in Oncotarget on August 4, 2022, entitled, "Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors."

17 Aug 2022

Study shows astrocytes as breeding grounds of SARS-CoV-2 during brain infection

Researchers evidenced the presence of SARS-CoV-2 in the human brain, infecting astrocytes and impairing neuronal function and viability.

15 Aug 2022

Gut microbial and immune parameters linked to heterogeneous inter-personal COVID-19 vaccine-triggered immunity

A new study identified the gut microbial and immune variables linked to heterogeneous messenger ribonucleic acid (mRNA) COVID-19 vaccine responses between individuals.

11 Aug 2022

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

10 Aug 2022

Using microrobotic platforms for endodontic therapy and diagnostics

With its irregularities and anatomical complexities, the root canal system is one of the most clinically challenging spaces in the oral cavity.

9 Aug 2022

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Researchers develop a genetically modified airway organoid system, which overcomes challenges related to natural variations in ACE2 levels

4 Aug 2022

Ex Vivo News and Research

Mount Sinai study suggests significant role of reactive oxygen species in maintaining healthy intestines

Can the gut be an alternative route for SARS-CoV-2 entry?

Lab-grown ‘pigmented’ skin-equivalent commercially available for the first time

SARS-CoV-2 generates amyloid in cerebral spinal fluid

Research reveals the role of microglia-neuron connections during brain development

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

Ultrasound color Doppler twinkling may aid the detection of breast biopsy markers

The role of some important antioxidants in major clinical outcomes of subjects with COVID-19

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

How does origin impact antiviral immune response?

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

Study contributes to better understanding of the changes in kinase activity in renal cell carcinoma

Study shows astrocytes as breeding grounds of SARS-CoV-2 during brain infection

Gut microbial and immune parameters linked to heterogeneous inter-personal COVID-19 vaccine-triggered immunity

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

Using microrobotic platforms for endodontic therapy and diagnostics

scRNA-seq of SARS-CoV-2 infected lung organoids finds NFKB Inhibitor Alpha increased in infected cells

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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