Gene Sequencing News and Research

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New genomic sequencing approach could be first step toward blood tests for early cancer detection

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high-intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

5 Jun 2017

Research uncovers role of gut microbiota in anti-obesity effects of dietary capsaicin

Scientists have discovered a dietary strategy that may address obesity by reducing endotoxemia, a major contributor to chronic, low-grade inflammation (CLGI).

23 May 2017

New finding could lead to more effective treatment decisions for younger colorectal cancer patients

Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

18 May 2017

Integrated BioBank of Luxembourg publishes "2016 In Review"

IBBL (Integrated BioBank of Luxembourg) is pleased to publish today its new digital annual report. “2016 In Review” looks back into the year 2016 in a refreshing way and highlights IBBL’s key achievements. Broadly speaking, it seems that IBBL has entered a transition phase in its history, having become a well established, valued and trusted partner in biomedical research.

17 May 2017

Scientists identify unusual mutations in endometriosis using gene sequencing tools

Using gene sequencing tools, scientists from Johns Hopkins Medicine and the University of British Columbia have found a set of genetic mutations in samples from 24 women with benign endometriosis, a painful disorder marked by the growth of uterine tissue outside of the womb.

11 May 2017

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson's disease.

26 Apr 2017

Researchers identify odorant troenan that can inhibit colorectal cancer growth

Growth of colorectal cancer cells can be inhibited with the odorant troenan. This is reported by the research team headed by Prof Dr Dr Dr habil. Hanns Hatt and Dr Lea Weber from Ruhr-Universität Bochum in the journal "PLOS One".

23 Mar 2017

Computational software that evaluates DNA samples may help in diagnosis, treatment of cancer

A research team from the United States and Canada has developed and successfully tested new computational software that determines whether a human DNA sample includes an epigenetic add-on linked to cancer and other adverse health conditions.

From Oxford Nanopore Technologies 24 Feb 2017

Study provides new insight into causes of rare metabolic disorder

Just before Rare Disease Day 2017, a study from the Monell Center and collaborating institutions provides new insight into the causes of trimethylaminura, a genetically-transmitted metabolic disorder that leads to accumulation of a chemical that smells like rotting fish.

14 Feb 2017

Researchers discover function of olfactory receptors in human heart muscle

Researchers have for the first time identified the function of olfactory receptors in the human heart muscle, such as are also present in the nose. One of the receptors reacts to fatty acids that occur in the blood, in patients with diabetes significantly above the normal range.

8 Feb 2017

Scientists decipher emergence of neuronal diversity in the cerebral cortex

The development of cerebral cortex plays a major role in the evolution of species and in particular for mankind.

30 Jan 2017

Researchers map genetic changes resulting from short bowel syndrome

Investigators at Children's Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome using a novel zebrafish model and by performing intensive gene sequencing.

25 Jan 2017

IBBL becomes first biobank to be accredited for next-generation microbial sequencing

Further to a successful follow-up audit, IBBL (Integrated BioBank of Luxembourg) becomes the first biobank worldwide to be accredited for the next-generation 16S rRNA gene sequencing, a cutting-edge method that takes forward research into the human microbiome.

23 Dec 2016

Wellcome Trust Sanger Institute open new biodata innovation centre and sequencing facility

The UK Prime Minister Rt Hon Theresa May today joined key stakeholders from across the life sciences sector to open the Wellcome Trust Sanger Institute’s new Bridget Ogilvie Building and the Biodata Innovation Centre at the Wellcome Genome Campus in Cambridge.

22 Nov 2016

Titin gene mutations affect heart function in healthy individuals, study finds

A multinational study by researchers from the UK, Singapore and Germany has discovered that gene mutations in a protein called titin affect heart function in healthy individuals.

22 Nov 2016

HC-based NGS helps detect genomic alterations not identified in routine lung cancer screening

The use of hybrid capture-based (HC-based) next-generation sequencing (NGS) to identify targetable oncogenic drivers in patients with lung adenocarcinoma results in the detection of genomic alterations (GAs) not identified in routine screening, and impacts treatment decisions and clinical outcomes.

17 Nov 2016

Scientists use latest sequencing technology to review genetic makeup of ataxias syndrome

According to a recent study published in JAMA Neurology, Northwestern Medicine scientists have examined more than a century of data of the genetic makeup of ataxias, a neurodegenerative disorder, to better understand the different forms of this devastating disease and how it affects patients.

8 Nov 2016

Mouths of migraine sufferers harbor more nitrate-reducing bacteria, study finds

Researchers at University of California San Diego School of Medicine have found that the mouths of migraine sufferers harbor significantly more microbes with the ability to modify nitrates than people who do not get migraine headaches.

19 Oct 2016

Novel DNA-altering method could lead to more treatment options for diseases

Researchers in Singapore have developed a new protein that can alter DNA in living cells with much higher precision than current methods.

13 Sep 2016

Study sheds new light on why colon cancers are more aggressive in African Americans

Case Comprehensive Cancer Center researchers, a research collaboration which includes University Hospitals Seidman Cancer Center and Case Western Reserve University, who last year identified new gene mutations unique to colon cancers in African Americans, have found that tumors with these mutations are highly aggressive and more likely to recur and metastasize.

1 Sep 2016