Inflammatory Disease News and Research

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The influence of immunosuppressive therapy on the development of adaptive immunity after SARS-CoV-2 vaccination

Researchers evaluated the impact of immunosuppressive therapies on the induction of adaptive immunity after COVID-19 vaccination.

5 Jul 2022

Researchers identify an epigenetic signature associated to the development of MIS-C after COVID-19

Researchers from the Cancer Epigenetics group led by Dr. Manel Esteller at the Josep Carreras Leukaemia Research Institute and Dr. Aurora Pujol, from the Bellvitge Biomedical Research Institute, have identified an epigenetic signature associated to the development of the Multisystem Inflammatory Syndrome in Children (MIS-C) after a SARS-CoV-2 virus infection.

27 Jun 2022

CHMP recommends approval of upadacitinib (RINVOQ®) for the treatment of adults with active non-radiographic axial spondyloarthritis

AbbVie today announced the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) recommended the approval of upadacitinib (RINVOQ® 15 mg, once daily) for the treatment of active non-radiographic axial spondyloarthritis (nr‑axSpA) in adult patients with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI), who have responded inadequately to nonsteroidal anti-inflammatory drugs (NSAIDs).*

27 Jun 2022

Study finds higher risk of premature death among patients with pediatric onset immune-mediated inflammatory disease

Patients with a pediatric onset immune-mediated inflammatory disease have a significantly higher risk of premature death, according to new research being presented today at the 54th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.

26 Jun 2022

Researchers model a complex childhood disease on-a-chip

Millions of children in low- and middle-income nations suffer from environmental enteric dysfunction (EED), a chronic inflammatory disease of the intestine that is the second leading cause of death in children under five years old.

23 Jun 2022

Infertility rate among women in the United States remains largely the same, analysis finds

During recent decades, the rate of infertility among women in the United States has remained largely the same, according to researchers at Johns Hopkins Medicine.

16 Jun 2022

Researchers investigate infertility trends in the United States from 1995 to 2019

In a new study, researchers estimated the changes in infertility in the United States (US) from 1995 to 2019.

16 Jun 2022

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

A new study led by Hospital for Special Surgery investigators in New York City has found that their computer vision tool effectively distinguishes rheumatoid arthritis (RA) from osteoarthritis (OA) in joint tissue taken from patients who underwent total knee replacement (TKR).

3 Jun 2022

The impact of SARS-CoV-2 linkage on outcomes in hospitalized children with PIMS across Canada

Researchers analyze the clinical effects and implications of SARS-CoV-2 infection in children who were hospitalized due to MIS-C.

1 Jun 2022

Mucosal COVID vaccine candidate powerfully protective in macaques

A recent research paper posted to the bioRxiv* preprint server illustrated the protective efficacy of the intranasal pediatric parainfluenza virus-vectored coronavirus disease 2019 (COVID-19) vaccine prospect, B/HPIV3/S-6P, in macaques.

26 May 2022

New study reveals the genetic mechanism behind severe staphylococcal infections

A common culprit of skin and respiratory infections, Staphylococcus aureus is highly unpredictable. Between 20 and 30 percent of people carry quiet colonies on their skin and in their nostrils, which seldom cause problems beyond the occasional rash.

19 May 2022

Study explores neurologic complications in pediatric COVID-19 cases

Researchers evaluated neurologic complications in pediatric cases of COVID-19.

18 May 2022

Study shows why COPD patients are more vulnerable to severe COVID-19

Researchers from the Centenary Institute and the University of Technology Sydney have published the first study showing why people with chronic obstructive pulmonary disease (COPD) are at higher risk of developing severe COVID-19.

18 May 2022

Chronic obstructive pulmonary disease leads to premature senescence of the immune system

A study conducted at the University of São Paulo's Medical School (FM-USP) in Brazil, with results reported in an article published in the journal Immunity & Ageing, shows that chronic obstructive pulmonary disease (COPD) leads to premature senescence (age-related impairment) of the immune system.

13 May 2022

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

A WEHI-led study has identified a new enzyme involved in controlling cell death, in findings that could lead to better treatment options for a range of inflammatory conditions, cancers and viruses.

12 May 2022

Researchers identify four new target molecules for future personalized MS treatment

Currently available therapies to treat multiple sclerosis (MS) lack precision and can lead to serious side effects.

27 Apr 2022

Penn scientists discover how one inflammatory disorder increases susceptibility to another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.

27 Apr 2022

Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease

Researchers investigated the longevity and intensity of the SARS-CoV-2 vaccine immune response in patients suffering from immune-mediated inflammatory diseases.

15 Apr 2022

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer's and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.

14 Apr 2022

‘Foreign body reaction’ to implants can be reduced by incorporating drug into silicone coating

Long-term use of implantable electronic medical devices – such as pacemakers and cochlear implants – is hampered by the body's reaction to foreign bodies.

14 Mar 2022