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Adherence to the EAT-Lancet diet reduces the risk of heart failure

Adherence to the EAT-Lancet diet, rich in plant-based foods, is associated with a reduced risk of heart failure, potentially mediated by specific plasma proteins, in a large population-based cohort study.

8 Apr 2024

Turning back the clock on aging immune systems: New treatment rejuvenates elderly defenses

Study demonstrated that selectively reducing myeloid-biased hematopoietic stem cells (my-HSCs) in aged mice rejuvenated the immune system, enhanced lymphopoiesis, reduced inflammation, and improved responses to viral infection, highlighting a potential strategy for countering age-related immune decline.

31 Mar 2024

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages.

26 Mar 2024

Advanced laser imaging illuminates molecular interactions driving lung cancer growth

Researchers have shown for the first time that a crucial interface in a protein that drives cancer growth could act as a target for more effective treatments.

19 Mar 2024

New compounds show potential to mimic benefits of exercise

Doctors have long prescribed exercise to improve and protect health. In the future, a pill may offer some of the same benefits as exercise.

18 Mar 2024

Arrayjet’s ArrayPlex platform selected by Immunome for use in its discovery of targeted cancer therapies

Immunome signs deal to use Arrayjet platform in its in-house screening operations.

From Arrayjet Ltd 18 Mar 2024

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Researchers use a combination of scRNA-seq and multiplexed error-robust fluorescence in situ hybridization to better understand cardiac cell types.

13 Mar 2024

LAG-3 protein structure may be the key to unlocking new cancer treatments

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.

11 Mar 2024

Gut bacteria strains could be the key to predicting cancer treatment success

Researchers discovered that gut microbiota strains can predict the effectiveness and adverse effects of immune checkpoint blockade (ICB) therapy in rare cancer patients.

6 Mar 2024

Revolutionary tool for tracking physical interactions between different cells

One of the fundamental goals of basic biology is understanding how diverse cell types work in concert to form tissues, organs, and organ systems.

6 Mar 2024

Comprehensive analysis of immune checkpoint inhibitors reveals endocrine toxicity patterns

Announcing a new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose a challenge of immune-related adverse events (irAEs), particularly endocrine toxicity, that can severely compromise patient well-being.

21 Feb 2024

Novel splicing mechanism for short introns discovered

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.

15 Feb 2024

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Researchers used an organ-wide approach to quantitatively analyze cell number, size, and identity regulation upon nutrient-induced tissue adaptation of the Drosophila midgut.

15 Feb 2024

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Researchers evaluated rational combination treatment regimens for advanced/metastatic non-small-cell lung cancer (NSCLC).

15 Feb 2024

Smoking, infection, and BMI found to significantly sway immune response, study shows

Study reveals how smoking, CMV latent infection, and BMI significantly influence cytokine release, impacting immune response variability and potentially affecting disease risk.

14 Feb 2024

Study finds interleukin-24 enhances CAR-T cell therapy's effectiveness against cancer stem cells

The effect of Interleukin-24 (IL-24) on CSCs and CAR-T cell therapy.

14 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

SARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation

Study reveals SARS-CoV-2 fragments mimic immune peptides, potentially driving the virus's inflammatory response, offering insights into COVID-19's severe inflammation mechanisms.

5 Feb 2024

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their effects on nociceptive neurons and the mechanism of action after 24 hours.

5 Feb 2024

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

1 Feb 2024

Ligand News and Research

Adherence to the EAT-Lancet diet reduces the risk of heart failure

Turning back the clock on aging immune systems: New treatment rejuvenates elderly defenses

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Advanced laser imaging illuminates molecular interactions driving lung cancer growth

New compounds show potential to mimic benefits of exercise

Arrayjet’s ArrayPlex platform selected by Immunome for use in its discovery of targeted cancer therapies

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

LAG-3 protein structure may be the key to unlocking new cancer treatments

Gut bacteria strains could be the key to predicting cancer treatment success

Revolutionary tool for tracking physical interactions between different cells

Comprehensive analysis of immune checkpoint inhibitors reveals endocrine toxicity patterns

Novel splicing mechanism for short introns discovered

Researchers discover new mechanism of action between the nutrient adaptation of intestinal stem cells and aging

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Smoking, infection, and BMI found to significantly sway immune response, study shows

Study finds interleukin-24 enhances CAR-T cell therapy's effectiveness against cancer stem cells

Never-before-documented genetic disorder causes rare lung disease

SARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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