Protein Synthesis News and Research

RSS

New molecular probe senses the state of proteome in live cells

The folding state of the proteins in live cells often reflect the cell’s general health. Australian scientists have developed a molecular probe that senses the state of the proteome—the entire set of the proteins—by measuring the polarity of the protein environment.

10 Jan 2020

SVC112 molecule acts specifically against head and neck cancer stem cells

The red, tube-shaped flowers of the firecracker bush (Bouvardia ternifolia), native to Mexico and the American Southwest, attract hummingbirds.

8 Jan 2020

Goethe University researchers develop new method to measure acute cellular changes

When cells are stressed, they initiate a complex and precisely regulated response to prevent permanent damage. One of the immediate reactions to stress signals is a reduction of protein synthesis (translation). Until now, it was difficult to measure such acute cellular changes. As reported in the latest online issue of the renowned journal Molecular Cell, researchers at Goethe University have now developed a method overcoming this hurdle.

5 Dec 2019

New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

A new study published in the journal Science Signaling on November 26, 2019, describes a mouse experiment, in which the immune response to the dengue vaccine was boosted when the mice were first given halofuginone, a plant compound that is well known to herbalists.

27 Nov 2019

Study points to two types of motion that keeps cells in shape

The health of cells is maintained, in part, by two types of movement of their nucleoli, a team of scientists has found. This dual motion within surrounding fluid, it reports, adds to our understanding of what contributes to healthy cellular function and points to how its disruption could affect human health.

26 Nov 2019

Researchers uncover novel pathogenic mechanism in Huntington’s disease

Researchers from the Institute of Neurosciences of the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease.

20 Nov 2019

New drug combo may improve pancreatic cancer therapy

A new study by scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered a combination of two cancer-fighting drugs that successfully worked on pancreatic tumor in mice, shrinking them significantly, and paving the way for a speedy clinical trial designed to test their efficacy in humans.

18 Nov 2019

U.S. Army project may lead to new class of self-healing materials and therapeutics for soldiers

Synthetic biologists working on a U.S. Army project have developed a process that could lead to a new class of synthetic polymers that may create new high-performance materials and therapeutics for Soldiers.

18 Nov 2019

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the U.S. -- with drugs that target the body's response to cellular stresses.

15 Nov 2019

Game-changing diagnostic test for prion diseases

Researchers have developed an effective way of testing for prion diseases, a group of fatal neurodegenerative illnesses caused by abnormally folded proteins.

8 Nov 2019

Scientists discover structure of novel RNA-modifying enzyme

RNA, or ribonucleic acid, is present in the cells of all living beings and required to synthesize proteins. A research team at the University of California, Riverside, has discovered the structure of a novel RNA-modifying enzyme, ZCCHC4, and identified the mechanism that controls how this enzyme recognizes its substrate.

6 Nov 2019

Stony Brook-led study reveals how proteome collapse process drives cell death and aging

Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study, to be published in PNAS, provides a biophysical model that reveals how damage accumulates in the shapes of cellular proteins with age and is a trigger to death.

16 Oct 2019

Histone modifications play important role in 'zygotic genome activation'

Scientists at Tokyo Institute of Technology observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to "histone H3", one of the proteins around which DNA is bound, play an important role in "zygotic genome activation" or transition of control of zebrafish embryonic development from maternal material to the zygote .

8 Oct 2019

Researchers identify genetic variants related to starting point of Parkinson's disease

Researchers from the Institute of Neurosciences of the University of Barcelona, Hospital Clínic and the August Pi i Sunyer Biomedical Research Institute have identified a group of genetic variants related to the starting point of Parkinson's disease.

27 Sep 2019

Biological clock responds positively to stress

In a recent study, researchers found that the integrated stress response (ISR) is essential to stimulate the circadian clock.

27 Sep 2019

University of Minnesota study finds link between stress and circadian clock health

The human body has an internal biological clock that is constantly running. Our well-being is dependent on the function of that clock. New research from the University of Minnesota Medical School found a little stress can make the circadian clock run better and faster.

26 Sep 2019

Russian researchers come up with faster method to discover antibiotics

Russian biochemists have identified a promising new class of antibiotics. Having studied over 125,000 molecules, they found that 2-pyrazol-1-yl-thiazole derivatives exhibit antibacterial properties.

26 Sep 2019

Dormant HIV reservoirs could be killed with RNA switch

Researchers from the University of California San Diego School of Medicine have found cellular triggers within the immune cells that could be controlled in order to kill dormant HIV-1 reservoirs in individuals with HIV-1.

25 Sep 2019

Microrna-based therapy may prove to be effective against chemotherapy-resistant cancers

A technology that manipulates microRNAs developed by Jingfang Ju, PhD, a biochemist and Professor in the Department of Pathology at the Renaissance School of Medicine at Stony Brook University, and colleagues has shown promise when used as anti-cancer therapeutic.

19 Sep 2019

DNA methylation closely linked to telomere length

Aging is associated with multiple disease conditions. Recently it has been found that many of these illnesses are linked to the length of the telomeres at the ends of every chromosome. Telomere length (TL) is affected by both genetic and epigenetic contributions.

2 Sep 2019