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Microglial states and their impact on Alzheimer's disease

Researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease.

3 Oct 2023

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

Micro-ribonucleic acids (miRNAs) linked to cognition and Alzheimer's disease (AD).

3 Oct 2023

New study reveals alarming cardiovascular risks from COVID

The study published in Nature Cardiovascular Research reveals that SARS-CoV-2, the virus causing COVID-19, can directly infect coronary vessels and arterial plaques, heightening the risk of cardiovascular complications like heart attacks and strokes. These findings offer critical insights into the increased long-term cardiovascular risks for COVID-19 survivors and open new avenues for targeted therapies.

1 Oct 2023

New toolbox solves 50-year-old blood group mystery

Currently, a lot is known about which genes are responsible for our individual blood groups, however not much is understood about how and why the levels of the blood group molecules differ between one person and another.

29 Sep 2023

New research reveals how social isolation impacts behavior and lifespan in social species

Researchers used Camponotus fellah (carpenter ants) as a model species to perform behavioral tracking and ribonucleic acid-sequencing (RNA-seq) to study the transcriptome-level differences between socially isolated workers versus workers in groups.

29 Sep 2023

What are the pharmacological properties of black goji berries?

The pharmacological effects of the components of Lycium ruthenicum Murray fruits.

29 Sep 2023

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease.

28 Sep 2023

Examining the cardiac pathology in fatal cases of yellow fever

The characteristics of yellow fever (YF)-related myocardial damage.

28 Sep 2023

Supercharged tomatoes: Scientists engineer fruits packed with amino acids and flavonoids

Spanish researchers use cisgenic engineering to create nutrient-packed tomatoes with higher levels of flavonoids and branched-chain amino acids, providing potential benefits for those on plant-based diets. The study shows promise for enhancing nutritional content in other crops, addressing malnutrition and health deficiencies.

27 Sep 2023

Mutations on a key SARS-CoV-2 viral protein linked to extreme immune responses

Mutations on a key SARS-CoV-2 viral protein are linked to extreme immune responses and could offer a novel vaccine target.

27 Sep 2023

Skin under pressure: tension affects skin's reaction to pollution

Researchers ratified previous findings that ozone (O3) exposure (an air pollutant) alters the antimicrobial peptide expression in the skin with and without tension.

27 Sep 2023

Key player in ovarian cancer may have implications for PCOS

Researchers explore the involvement and altered expression of BBOX1-AS1 and microRNA-19b in polycystic ovary syndrome.

26 Sep 2023

Could next-generation antimicrobial agents act as an alternative to standard antibiotics?

Next-generation antimicrobial agents (NGAs) as a potential alternative to standard antibiotics

26 Sep 2023

Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

How are SARS-CoV-2 variants outsmarting our immune system and vaccines?

Researchers use multiomics analysis to understand how SARS-CoV-2 variants, including Alpha, Delta, and Omicron, modulate the host's cellular responses and adapt to evade human immunity. The study highlights the potential for targeted therapies against both adaptive and innate immune responses.

25 Sep 2023

Study provides insights into human 8-cell-like cells and early embryonic development

The onset of embryo-specific gene transcription, also known as embryonic genome activation (EGA), is a crucial step in the developmental journey of an organism.

22 Sep 2023

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Researchers proposed a simplified approach for analyzing mRNA vaccines using long-read sequencing.

22 Sep 2023

Can COVID-19 vaccines turn the tide on long-haul symptoms?

The study finds that COVID-19 vaccination can significantly reduce symptoms and improve well-being in patients suffering from post-COVID-19 conditions (PCC). Vaccination also lowered systemic markers of inflammation but did not entirely eliminate persistent SARS-CoV-2 antigens, which may continue to contribute to inflammation.

22 Sep 2023

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

Creating CAR-T cells with enhanced immune memory to fight cancer

Among available immunotherapies, the use of «CAR-T» cells is proving extremely effective against certain blood cancers, but only in half of patients.

20 Sep 2023

Transcription News and Research

Microglial states and their impact on Alzheimer's disease

Identification of Alzheimer's disease-associated micro-RNA biomarkers through network-based analysis

New study reveals alarming cardiovascular risks from COVID

New toolbox solves 50-year-old blood group mystery

New research reveals how social isolation impacts behavior and lifespan in social species

What are the pharmacological properties of black goji berries?

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Examining the cardiac pathology in fatal cases of yellow fever

Supercharged tomatoes: Scientists engineer fruits packed with amino acids and flavonoids

Mutations on a key SARS-CoV-2 viral protein linked to extreme immune responses

Skin under pressure: tension affects skin's reaction to pollution

Key player in ovarian cancer may have implications for PCOS

Could next-generation antimicrobial agents act as an alternative to standard antibiotics?

Intranasal vaccine shows promise against COVID variants in hamsters

How are SARS-CoV-2 variants outsmarting our immune system and vaccines?

Study provides insights into human 8-cell-like cells and early embryonic development

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Can COVID-19 vaccines turn the tide on long-haul symptoms?

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

Creating CAR-T cells with enhanced immune memory to fight cancer

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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