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Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression.

31 Oct 2025

Sensory effects of flavanols trigger physiological responses in the brain

Astringency is a dry, puckering, rough, or sandpapery sensation in the mouth caused by plant-derived polyphenols.

31 Oct 2025

Massive cross-ancestry study explains why obesity risks differ around the world

A massive cross-ancestry genetic study involving over 839,000 adults identified 13 genes linked to obesity, including five never before associated with the condition. The findings highlight how global genetic diversity can uncover new biological pathways and potential treatment targets for obesity.

31 Oct 2025

New method yields up to twice as many therapeutic myogenic cells as previous protocols

If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation.

30 Oct 2025

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

30 Oct 2025

Hydroxytyrosol from olives shows new promise as a brain-protective compound

This review highlights hydroxytyrosol's role as a neuroprotective agent, activating key pathways for mental and vascular health through olive-derived compounds.

29 Oct 2025

New technology improves the efficiency of protein production in E. coli

Proteins sourced from microorganisms are attracting attention for their potential in biomanufacturing a variety of products, including pharmaceuticals, industrial enzymes, and diagnostic antibodies.

28 Oct 2025

Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding

Maternal peanut and peanut butter consumption during pregnancy and breastfeeding shaped DNA methylation patterns in children, particularly in genes regulating neurodevelopment and inflammation. These findings suggest maternal diet can prime offspring epigenetic sensitivity to breastfeeding duration.

27 Oct 2025

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Study reveals that group B [FeFe]-hydrogenase is the primary enzyme driving fermentative hydrogen production in the healthy human gut, mainly through Bacteroides species. These genes are significantly depleted in Crohn’s disease, indicating a metabolic shift and altered hydrogen cycling dominated by respiratory bacteria

27 Oct 2025

Study finds evidence for repurposing thiostrepton as an anti-rhabdomyosarcoma drug

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

27 Oct 2025

New mechanism explains life-threatening pre-eclampsia at the molecular level

Pre-eclampsia is one of the most serious complications in pregnancy, affecting millions of women and newborns worldwide and potentially life-threatening. Despite intensive research, it has remained unclear what processes in the placenta lead to the disease.

21 Oct 2025

New insights reveal persistent genome structure during cell division

Before cells can divide, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material.

17 Oct 2025

New insights into how bacteria can drive treatment resistance in oral and colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer.

16 Oct 2025

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

Transcription News and Research

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Sensory effects of flavanols trigger physiological responses in the brain

Massive cross-ancestry study explains why obesity risks differ around the world

New method yields up to twice as many therapeutic myogenic cells as previous protocols

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Hydroxytyrosol from olives shows new promise as a brain-protective compound

New technology improves the efficiency of protein production in E. coli

Eating peanuts while pregnant may influence how a child’s genes respond to breastfeeding

Scientists uncover the gut’s hidden hydrogen engine and how it falters in Crohn’s disease

Study finds evidence for repurposing thiostrepton as an anti-rhabdomyosarcoma drug

New mechanism explains life-threatening pre-eclampsia at the molecular level

New insights reveal persistent genome structure during cell division

New insights into how bacteria can drive treatment resistance in oral and colorectal cancer

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Decoding the signaling networks and metabolic dysregulation underlying sepsis

Multidimensional regulation of stem cell fate by the cohesin complex

Study reveals how DKK3 triggers smooth muscle cell transformation in aortic aneurysm

Study reveals how RfaH protein acts as a protective shield for bacterial genes

Newly identified protein acts as a traffic controller for DNA replication

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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