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Clinical-grade soluble human ACE2 shown to inhibit SARS-CoV-2 Omicron variant

New study findings show that the clinical-grade soluble ACE2 effectively inhibits the SARS-CoV-2 Omicron variant, which proves the principle of an effective therapeutic approach against Omicron-driven COVID-19 infections.

30 Dec 2021

Omicron analysis shows no clear evidence for increased virulence or lethality

Researchers conducted a genomic sequencing and epidemiological correlation analysis of the SARS-CoV-2 Omicron variant.

29 Dec 2021

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Now in new research, scientists from the University of Leicester have been investigating how these mutations alter the affinities of RBDs to ACE2.

28 Dec 2021

Study highlights importance of positive and negative selection in evolution of SARS-CoV-2 variants

Researchers from the University of Colorado Anschutz Medical Campus have been investigating the changes imparted on the Gamma variant by three RBD mutations.

28 Dec 2021

Cryo-EM of Omicron variant reveals antibody evasion by spike-ACE2 complex

Researchers compare the obtained binding affinities to wild-type and Delta spike proteins to determine the impact of Omicron mutations.

23 Dec 2021

Omicron evades roughly twice the number of SARS-CoV-2 neutralizing antibodies than Delta

New study results highlight that Omicron has an increased affinity to ACE-2 receptors, therefore, has increased infectivity, viral load, and transmissibility compared to other variants of concern, including the Delta variant.

22 Dec 2021

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

A team of scientists from Canada has recently characterized a panel of nanobodies against the spike protein of SARS-CoV-2.

22 Dec 2021

Computational analysis of the effect of SARS-CoV-2 Omicron variant spike protein mutations

A new study highlights the potential evolutionary trade-off observed in the omicron variant, detailing the dynamics of the protein structure, its interactions, and subsequent effects.

20 Dec 2021

Identifying protein targets in SARS-CoV-2 via machine learning

A new study provides insight on using an ML-based algorithm to analyze and predict therapeutic targets in emerging pathogens with a range of mutations.

17 Dec 2021

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Researchers investigated the mutations reported in the Omicron variant and its likely impact on the use of therapeutic antibodies in COVID-19 treatment as well as on vaccinated individuals.

17 Dec 2021

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

A new study measured antibody levels from blood samples of vaccinated individuals and individuals who recovered from COVID-19 illness.

17 Dec 2021

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

Researchers compared the binding of the new SARS-CoV-2 VOC Omicron’s RBD and ACE2 receptor with the original Wuhan SARS-CoV-2 strain and other VOCs such as Beta and Delta.

15 Dec 2021

Structure of human receptor and Omicron variant

Researchers studied the complex structure of the receptor-binding domain of the omicron variant with the human host receptor angiotensin-converting enzyme 2.

15 Dec 2021

Researchers develop a universal SARS-CoV-2 neutralizing antibody

A new study has been published in Frontiers in Immunology, where scientists developed a universal SARS-CoV-2 neutralizing antibody, MG1141A.

13 Dec 2021

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Researchers from the Biological Defence Programme of Singapore have investigated six of these antibodies.

13 Dec 2021

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

In a new research paper, a group of scientists from various institutions offers a semi-supervised custom pipeline for annotating all SARS-CoV-2 genes, proteins, and functional domains.

12 Dec 2021

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

In a recent study, ten human PDZ-containing proteins showed significant interactions with the SARS-CoV-2 E protein in a PBM-dependent manner.

12 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

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8 Dec 2021

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

In a new study, scientists have computationally predicted the structure of the Omicron spike RBD from available sequences and explored the dynamics of antigen-antibody interactions.

8 Dec 2021

binding affinity News and Research

Clinical-grade soluble human ACE2 shown to inhibit SARS-CoV-2 Omicron variant

Omicron analysis shows no clear evidence for increased virulence or lethality

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Study highlights importance of positive and negative selection in evolution of SARS-CoV-2 variants

Cryo-EM of Omicron variant reveals antibody evasion by spike-ACE2 complex

Omicron evades roughly twice the number of SARS-CoV-2 neutralizing antibodies than Delta

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

Computational analysis of the effect of SARS-CoV-2 Omicron variant spike protein mutations

Identifying protein targets in SARS-CoV-2 via machine learning

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

Structure of human receptor and Omicron variant

Researchers develop a universal SARS-CoV-2 neutralizing antibody

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Autonomous genome annotation of SARS-CoV-2 genes, proteins and domains

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

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