Mouse Model News and Research

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Researchers develop mouse model to study consequences of fungal infection in the brain

Fungal infections are emerging as a major medical challenge, and a team led by researchers at Baylor College of Medicine has developed a mouse model to study the short-term consequences of fungal infection in the brain.

4 Jan 2019

Study: Mice lacking PARL protein display specific problems in the nervous system reminiscent of Leigh syndrome

Leuven researchers led by professor Bart De Strooper (VIB-KU Leuven) have identified a new role for PARL, a protein that has been linked to Parkinson's disease.

3 Jan 2019

Study identifies possible new strategies to treat silent seizures in children

As early as 3 months of age, infants with a severe form of epilepsy called Dravet syndrome start having convulsive seizures, during which their arms and legs jerk repeatedly. As they become toddlers, another type of seizure begins to appear.

2 Jan 2019

Genetically diverse mouse models improves usability for precision medicine for Alzheimer's

Incorporating genetic diversity into a mouse model of Alzheimer's disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a study funded by the National Institute on Aging, part of the National Institutes of Health.

28 Dec 2018

Biologists discover how protein clumps damage cells in Parkinson's disease

Biologists studying Parkinson's disease have long hoped to solve the mystery of the telltale "clumps." Scientists want to know how clumps of misfolded proteins damage brain cells and contribute to the disease.

21 Dec 2018

New study reveals how fatty diet can lead to serious form of liver disease

A new study by Keck School of Medicine of USC researchers shows there's yet another reason to avoid a high fat, high cholesterol diet: It can trigger changes in the immune system that lead to a serious form of non-alcoholic fatty liver disease known as non-alcoholic steatohepatitis.

20 Dec 2018

Experimental gene therapy extends lifespan of mice suffering from untreatable mitochondrial disease

Researchers at the University of Helsinki and Folkhälsan Research Center have, together with their collaborators, for the first time demonstrated in a mouse model that partial restoration of respiratory chain function in mitochondria, which serve as cellular power plants, may be sufficient to entirely prevent symptoms of a severe mitochondrial disorder.

20 Dec 2018

Tau protein reduces neural activity in Alzheimer's mouse models

A study from Massachusetts General Hospital investigators sheds new light on how the hallmarks of Alzheimer's disease - amyloid-beta (A-beta) plaques and neurofibrillary tangles containing the protein tau - produce their damaging effects in the brain.

19 Dec 2018

MUSC researchers identify potential therapeutic target for lung fibrosis

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina report that they have identified a potential therapeutic target for lung fibrosis or scarring.

19 Dec 2018

Viral hepatitis: Liver failure caused by defects in the vascular system

In severe cases, a viral hepatitis infection can result in liver failure. A team from the Technical University of Munich has now discovered how this occurs: by immune cells attacking cells in the vascular system, which disrupts the organ's blood and nutrient supply.

19 Dec 2018

DNA “webs” shown to promote metastasis in ovarian cancer

Researchers have found that neutrophils cast DNA “webs” that aid the spread of ovarian cancer cells to new tissues (a process known as metastasis).

19 Dec 2018

Mouse study uncovers how marijuana may damage some adolescent brains

In a study of adolescent mice with a version of a gene linked to serious human mental illnesses, Johns Hopkins Medicine researchers say they have uncovered a possible explanation for how marijuana may damage the brains of some human teens.

18 Dec 2018

Research suggests a promising therapeutic target to treat or prevent metabolic disorders

Research led by Suresh Alahari, PhD, Fred Brazda Professor of Biochemistry and Microbiology at LSU Health New Orleans, suggests a novel protein may be a promising therapeutic target to treat or prevent metabolic disorders.

18 Dec 2018

Study uncovers novel details about vulnerability of one brain cell to Alzheimer's

Better tactics for detecting, preventing and treating Alzheimer's disease depend on a clearer understanding of cellular-level changes in the minds of patients, and a new study has uncovered novel details about the vulnerability of one type of brain cell.

18 Dec 2018

New bacterial species may help fight obesity and metabolic disorders

The MyNewGut project has discovered new bacterial species and strains in healthy people that seem to be effective against obesity, metabolic and mental disorders related to stress and obesity (e.g. depression).

17 Dec 2018

Recurrence of urinary tract infection may depend on bacterial strain, study shows

Genetically diverse bacterial strains that cause urinary tract infections differ in their ability to trigger protective immune responses in mice, potentially explaining why these infections frequently recur in many patients, according to a study published December 13 in the open-access journal PLOS Pathogens by Thomas Hannan and Scott Hultgren of Washington University School of Medicine, and colleagues.

14 Dec 2018

New findings could help develop new immunotherapies against cancer

NK cells, or natural killer cells, play an important role in the body's defences against cancer and various infections.

14 Dec 2018

Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies

Using a mouse model of necrotizing enterocolitis -- a potentially fatal condition that causes a premature infant's gut to suddenly die -- researchers at Johns Hopkins say they have uncovered the molecular causes of the condition and its associated brain injury.

14 Dec 2018

Scientists develop new stem cell line to study conversion of stem cells into muscle

To help patients with muscle disorders, scientists at The University of Texas Health Science Center at Houston (UTHealth) have engineered a new stem cell line to study the conversion of stem cells into muscle. Findings appeared in Cell Reports.

13 Dec 2018

Study: Loss of tight junction barrier protein results in gastric cancer development

Tight junctions are multi-protein complexes that serve as barriers in epithelial tissues such as the skin or lining of the gut. Loss of a specific tight junction barrier protein, claudin 18, occurs in the majority of gastric cancer patients and is correlated with poor prognosis in patients with advanced gastric cancer.

13 Dec 2018

Mouse Model News and Research

Researchers develop mouse model to study consequences of fungal infection in the brain

Study: Mice lacking PARL protein display specific problems in the nervous system reminiscent of Leigh syndrome

Study identifies possible new strategies to treat silent seizures in children

Genetically diverse mouse models improves usability for precision medicine for Alzheimer's

Biologists discover how protein clumps damage cells in Parkinson's disease

New study reveals how fatty diet can lead to serious form of liver disease

Experimental gene therapy extends lifespan of mice suffering from untreatable mitochondrial disease

Tau protein reduces neural activity in Alzheimer's mouse models

MUSC researchers identify potential therapeutic target for lung fibrosis

Viral hepatitis: Liver failure caused by defects in the vascular system

DNA “webs” shown to promote metastasis in ovarian cancer

Mouse study uncovers how marijuana may damage some adolescent brains

Research suggests a promising therapeutic target to treat or prevent metabolic disorders

Study uncovers novel details about vulnerability of one brain cell to Alzheimer's

New bacterial species may help fight obesity and metabolic disorders

Recurrence of urinary tract infection may depend on bacterial strain, study shows

New findings could help develop new immunotherapies against cancer

Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies

Scientists develop new stem cell line to study conversion of stem cells into muscle

Study: Loss of tight junction barrier protein results in gastric cancer development

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