Protein C News and Research

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David Calligaris wins ABC Best Paper Award

David Calligaris is the winner of this year's ABC Best Paper Award, presented by the Springer journal Analytical and Bioanalytical Chemistry. In a paper published in ABC, lead author Calligaris and his colleagues describe a novel system using mass spectrometry as an intraoperative tool. Their method opens new possibilities to detect additional tumour markers which are useful in diagnosing brain and breast tumours during surgery.

11 Feb 2016

Study identifies FGF21 protein as potential therapeutic agent for cardiovascular diseases, type 2 diabetes

New research on the blood lipid-lowering protein FGF21 shows how it redistributes fatty acids by two distinct mechanisms. The discovery could lead to improved pharmaceutical treatment for type 2 diabetes and other obesity-related diseases.

11 Feb 2016

Leeds scientists to start computer drug research to find cure for Ebola virus

Scientists at the University of Leeds will run the equivalent of password cracking software to find the chemical keys to defeating the Ebola virus.

11 Feb 2016

Unlocking intrinsically disordered proteins: an interview with Peter Wright

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years.

From Bruker BioSpin Group 11 Feb 2016

CMU researchers create robotically-driven experimentation system to reduce drug discovery cost

Researchers from Carnegie Mellon University have created the first robotically driven experimentation system to determine the effects of a large number of drugs on many proteins, reducing the number of necessary experiments by 70 percent.

11 Feb 2016

Simple physics may play key role in helping the body to fight infection

Simple physics may play a larger role than previously thought in helping control key bodily processes - such as how the body fights infection.

11 Feb 2016

CHLA researchers develop novel model for studying neonatal lung disorder

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have created a novel model for studying a lung disorder of newborn babies. Their study, published in PLOS ONE on February 10, describes the first model that allows investigators to consider the chronic effects of developmental lung disease.

11 Feb 2016

Scientists propose use of mathematical models to find better treatment for bladder cancer

MIPT scientists together with their colleagues from St. Petersburg and Israel have analyzed more than 500 previously published scientific articles and proposed their own approach to the choice of methods used for the treatment of one of the most common cancers.

11 Feb 2016

SBP researchers identify molecular switch that controls genes needed to repair skeletal muscle

Researchers at Sanford Burnham Prebys Medical Research Institute (SBP) have conclusively identified the protein complex that controls the genes needed to repair skeletal muscle.

11 Feb 2016

Kumamoto University researchers identify protein that limits severity of Alport syndrome

Researchers from Kumamoto University, Japan have identified a protein that limits the severity of Alport syndrome, a type of genetic kidney disease. The finding can provide clues that point toward new therapeutic approaches for Alport syndrome.

11 Feb 2016

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Could a kinase inhibitor some doctors prescribe to keep blood flowing after brain surgery be used to treat neurodegeneration? New research suggests it might be worth exploring the question.

10 Feb 2016

LMU researchers identify new drug target for atherosclerosis

The enzyme Dicer processes RNA transcripts, cutting them into short segments that regulate the synthesis of specific proteins. An Ludwig-Maximilians-Universitaet in Munich team has shown that Dicer promotes the development of atherosclerosis, thus identifying a new drug target.

10 Feb 2016

Helpful protein can change genetic sequence of normal cells and make mutations that cause cancers

Washington State University researchers have determined how a protein that helps cells fight viruses can also cause genetic mutations that lead to cancer.

10 Feb 2016

2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

A first-ever interlaboratory study of four versions of a therapeutic protein drug—all manufactured from living cells—reports that an established analytical tool akin to magnetic resonance imaging reliably assessed the atomic structures of the biologically similar products, yielding the equivalent of a fingerprint for each.

10 Feb 2016

Muscle protein titin plays vital role in Frank-Starling mechanism

Researchers at Illinois Institute of Technology and Loyola University have discovered new clues in the 100-year-old mystery of the Frank-Starling law of the heart: What makes the heart contract more strongly at longer lengths given the same level of calcium activation?

10 Feb 2016

Simple change in diet could boost vitamin D levels for people suffering from Type 2 diabetes

A simple change in diet could boost vitamin D levels for millions of Americans suffering from Type 2 diabetes, according to new research from Iowa State University published in the Journal of Agricultural and Food Chemistry.

10 Feb 2016

Penn investigators devise new method to map 'transcriptome'

A new way of mapping the "transcriptome" -- the collection of RNA read-outs that are expressed by a cell's active genes -- has been devised by researchers from the Perelman School of Medicine at the University of Pennsylvania.

10 Feb 2016

Temple team describes use of cadaver DNA to advance genetics learning in medical curriculum

Cadavers have long been one of the most important resources for anatomy teaching in medical school. Now, they are also at the forefront of cutting-edge genetics teaching, thanks to innovative thinking by professors at the Lewis Katz School of Medicine at Temple University.

10 Feb 2016

Certain gene variants influence what we eat

If you're fat, can you blame it on your genes? The answer is a qualified yes. Maybe. Under certain circumstances. Researchers are moving towards a better understanding of some of the roots of obesity.

10 Feb 2016

New technique allows better understanding of cellular stress reaction

Stress in the body's cells is both the cause and consequence of inflammatory diseases or cancer. The cells react to stress to protect themselves. Researchers at the University of Zurich have now developed a new technique that allows studying a fundamental response to stress in much more detail than previously possible: the ADP-ribosylation of chromatin.

9 Feb 2016

Protein C News and Research

David Calligaris wins ABC Best Paper Award

Study identifies FGF21 protein as potential therapeutic agent for cardiovascular diseases, type 2 diabetes

Leeds scientists to start computer drug research to find cure for Ebola virus

Unlocking intrinsically disordered proteins: an interview with Peter Wright

CMU researchers create robotically-driven experimentation system to reduce drug discovery cost

Simple physics may play key role in helping the body to fight infection

CHLA researchers develop novel model for studying neonatal lung disorder

Scientists propose use of mathematical models to find better treatment for bladder cancer

SBP researchers identify molecular switch that controls genes needed to repair skeletal muscle

Kumamoto University researchers identify protein that limits severity of Alport syndrome

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

LMU researchers identify new drug target for atherosclerosis

Helpful protein can change genetic sequence of normal cells and make mutations that cause cancers

2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

Muscle protein titin plays vital role in Frank-Starling mechanism

Simple change in diet could boost vitamin D levels for people suffering from Type 2 diabetes

Penn investigators devise new method to map 'transcriptome'

Temple team describes use of cadaver DNA to advance genetics learning in medical curriculum

Certain gene variants influence what we eat

New technique allows better understanding of cellular stress reaction

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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