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Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

CQDM, Brain Canada and the Ontario Brain Institute award close to $8.5M to six (6) multi-disciplinary and multi-provincial research teams across Canada to address unmet needs in neuroscience within their Focus on Brain strategic initiative. To this amount, $1.5M is added from the various research entities involved as in-kind contributions.

27 May 2015

Soy supplement does not improve lung function, clinical outcomes in patients with asthma

Although some data have suggested that supplementation with soy isoflavone may be an effective treatment for patients with poor asthma control, a randomized trial that included nearly 400 children and adults found that use of the supplement did not result in improved lung function or clinical outcomes, including asthma symptoms and episodes of poor asthma control, according to a study in the May 26 issue of JAMA.

27 May 2015

Scientists identify molecular 'lock' that enables Ebola virus to gain entry to cells

An international team including scientists from Albert Einstein College of Medicine of Yeshiva University and the U.S. Army Medical Research Institute of Infectious Diseases has identified the molecular "lock" that the deadly Ebola virus must pick to gain entry to cells.

27 May 2015

Tiny drug-delivery system can help identify brain tumor types through 'virtual biopsies'

Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through "virtual biopsies" and then attack the molecular structure of the disease.

27 May 2015

UF research opens door to better diagnosis and treatment of Parkinson's disease

University of Florida researchers have identified a biomarker that shows the progression of Parkinson's disease in the brain, opening the door to better diagnosis and treatment of the degenerative disease.

27 May 2015

DNA changes during drug withdrawal may offer promising ways to develop effective addiction treatments

One of the major challenges of cocaine addiction is the high rate of relapse after periods of withdrawal and abstinence. But new research reveals that changes in our DNA during drug withdrawal may offer promising ways of developing more effective treatments for addiction.

27 May 2015

People who have higher HDL function experience fewer heart attacks later in life

HDL is the 'good cholesterol' that helps remove fat from artery walls, reversing the process that leads to heart disease. Yet recent drug trials and genetic studies suggest that simply pushing HDL levels higher doesn't necessarily reduce the risk of heart disease.

27 May 2015

Toronto researchers design simple chip for faster, easier detection of antibiotic-resistant bacteria

We live in fear of 'superbugs': infectious bacteria that don't respond to treatment by antibiotics, and can turn a routine hospital stay into a nightmare. A 2015 Health Canada report estimates that superbugs have already cost Canadians $1 billion, and are a "serious and growing issue." Each year two million people in the U.S. contract antibiotic-resistant infections, and at least 23,000 people die as a direct result.

27 May 2015

Canadian researchers shed light on molecular dynamics of chronic pain

Chronic pain affects hundreds of millions of people worldwide and is a major cause of disability, causing more disability than cancer and heart disease. Canadian researchers, including Michael Salter at SickKids are shedding light on the molecular dynamics of chronic pain. They have uncovered a critical role for a class of cells present in the brain and spinal cord, called microglia, in pain.

27 May 2015

Study: Drugs that block NPC1 protein could be used to treat Ebola virus disease

A new study has demonstrated that a protein called Niemann-Pick C1 (NPC1) is critical for the Ebola virus to infect a host. The study, published in the May/June issue of mBio, the online open-access journal of the American Society for Microbiology, suggests that drugs that block NPC1 could be used to treat this deadly disease.

27 May 2015

New in vitro system could become important tool in search for potential drugs against Alzheimer’s

A typical characteristic of the brain of an Alzheimer sufferer is the presence of insoluble Tau protein aggregates. Scientists at VIB, KU Leuven and Janssen Pharmaceutica have demonstrated that the distribution of these aggregates through the brain is facilitated by synaptic connections between brain cells.

26 May 2015

Study indicates that arthritis patients may not be taking medication as regularly as prescribed

Researchers from the Arthritis Research UK Centre for Epidemiology at The University of Manchester found that 40% of patients scored low on an adherence questionnaire at least once during their time in a recent study, indicating that they might not be taking their expensive biological therapies as regularly as prescribed.

26 May 2015

Study could offer new way to treat, prevent diabetes-associated blindness

Reporting on their study with lab-grown human cells, researchers at The Johns Hopkins University and the University of Maryland say that blocking a second blood vessel growth protein, along with one that is already well-known, could offer a new way to treat and prevent a blinding eye disease caused by diabetes.

26 May 2015

Removing accumulated mutant p53 protein regresses tumors, increases cancer survival

Removing accumulated mutant p53 protein from a cancer model showed that tumors regress significantly and survival increases. This finding, by an international team of cancer researchers led by Ute Moll, MD, Professor of Pathology at Stony Brook University School of Medicine, is reported in a paper published advanced online May 25 in Nature.

26 May 2015

Researchers identify six mRNA isoforms that could be used to diagnose early-stage ovarian cancer

Ovarian cancer is notoriously difficult to diagnose and treat, making it an especially fatal disease. Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have now identified six mRNA isoforms (bits of genetic material) produced by ovarian cancer cells but not normal cells, opening up the possibility that they could be used to diagnose early-stage ovarian cancer.

26 May 2015

Researchers identify gene vital to production of pain-sensing neurons in humans

A gene essential to the production of pain-sensing neurons in humans has been identified by an international team of researchers co-led by the University of Cambridge. The discovery, reported today in the journal Nature Genetics, could have implications for the development of new methods of pain relief.

26 May 2015

Drugs News and Research

Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

Soy supplement does not improve lung function, clinical outcomes in patients with asthma

Scientists identify molecular 'lock' that enables Ebola virus to gain entry to cells

Tiny drug-delivery system can help identify brain tumor types through 'virtual biopsies'

UF research opens door to better diagnosis and treatment of Parkinson's disease

DNA changes during drug withdrawal may offer promising ways to develop effective addiction treatments

People who have higher HDL function experience fewer heart attacks later in life

Toronto researchers design simple chip for faster, easier detection of antibiotic-resistant bacteria

Canadian researchers shed light on molecular dynamics of chronic pain

Study: Drugs that block NPC1 protein could be used to treat Ebola virus disease

New in vitro system could become important tool in search for potential drugs against Alzheimer’s

Study indicates that arthritis patients may not be taking medication as regularly as prescribed

Study could offer new way to treat, prevent diabetes-associated blindness

Removing accumulated mutant p53 protein regresses tumors, increases cancer survival

Researchers identify six mRNA isoforms that could be used to diagnose early-stage ovarian cancer

Researchers identify gene vital to production of pain-sensing neurons in humans

Scientists reveal how disruption of DISC1 gene involved in mental illness affects the brain

Aptensio XR once-daily treatment for ADHD to be available in Summer 2015

Clinical genomic sequencing could impact treatment decisions in advanced prostate cancer patients

TGen and Baylor partnership set to increase treatment options for cancer patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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