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Study compares effectiveness of treatments for metastatic non-clear cell kidney cancers

A head-to-head comparison of two biologic therapies used to treat a subset of patients with advanced kidney cancers provides much-needed clarity on the preferred treatment for the first line of attack.

15 May 2015

Researchers discover how and where chromosome fragile sites occur in human DNA

Using a novel method they developed to map chromosome breaks in a model organism, the budding yeast, Wenyi Feng, Ph.D., of Upstate Medical University and her colleagues have discovered new information as to how and where chromosome fragile sites can occur in human DNA. These sites are frequently observed in cancer cells and are responsible for causing genomic rearrangements.

15 May 2015

CASI Pharmaceuticals reports net loss of $1.8 million for first quarter 2015

CASI Pharmaceuticals, Inc., a biopharmaceutical company dedicated to the acquisition, development and commercialization of innovative therapeutics addressing cancer and other unmet medical needs for the global market with a commercial focus on China today reported financial results for the three months ended March 31, 2015.

15 May 2015

Drug combination lengthens lives of metastatic colorectal cancer patients

A drug developed 50 years ago and abandoned because it was considered to be too toxic has gained a second life in an international clinical trial. Research led by scientists at Dana-Farber Cancer Institute showed the drug and a potentiating agent lengthened the lives of patients with metastatic colorectal cancer, all of whom had exhausted available standard treatments.

15 May 2015

Vagus nerve stimulation effective in inhibiting cortical spreading depression

A poster presentation at the International Headache Congress in Valencia, Spain reports that VNS inhibits cortical spreading depression (CSD), which is known to be the cause of migraine aura and a trigger for headache.

15 May 2015

Mifepristone-eribulin combination clinically active in triple-negative breast cancer patients

Corcept Therapeutics Incorporated, a pharmaceutical company engaged in the discovery, development and commercialization of drugs that treat severe metabolic, oncologic and psychiatric disorders by modulating the effects of cortisol, today announced results of a multi-center Phase 1/2 dose-escalation study of mifepristone and chemotherapy drug eribulin (Halaven) that show it is well tolerated and clinically active in patients with triple-negative breast cancer.

15 May 2015

Sheffield scientists to showcase novel medical discoveries during International Clinical Trials Day

WORLD-leading researchers and scientists from Sheffield Teaching Hospitals Foundation Trust and the University of Sheffield will be giving people in Sheffield and beyond a unique insight into how they can contribute to groundbreaking medical discoveries during International Clinical Trials Day (Wednesday 20 May 2015).

15 May 2015

Combination of contraceptive and cholesterol-lowering drugs kills cancer cells in a new way

The combination of a cholesterol-lowering drug, Bezafibrate, and a contraceptive steroid, Medroxyprogesterone Acetate, could be an effective, non-toxic treatment for a range of cancers, researchers at the University of Birmingham have found.

15 May 2015

Combination therapy provides promising results in patients with advanced non-small cell lung cancer

An early phase study testing an anti-PDL1 agent in combination with standard chemotherapy in the treatment of advanced non-small cell lung cancer has provided promising early results, prompting multiple phase III studies in lung cancer. The findings are being presented at the annual meeting of the American Society of Clinical Oncology.

15 May 2015

Scientists identify new molecules that destroy cancer cells, save healthy ones

Researchers have identified new molecules that kill cancer cells while protecting healthy cells and that could be used to treat a variety of different cancers. The research shines a light on what happens to cells at the moment they become cancerous.

15 May 2015

Ground-breaking discovery could revolutionise lupus treatments

A ground-breaking discovery by Monash University researchers could revolutionise treatments given to lupus sufferers, saving thousands of people each year from serious illness or death caused by secondary infections.

14 May 2015

CARE Pharmacies, Aureus Health Services partner to improve patient care

CARE Pharmacies Cooperative, Inc., an influential and growing independent retail chain, and Aureus Health Services, Inc., a national specialty pharmacy and health services company and Portfolio Company of BelHealth Investment Partners, LLC, announced their partnership in a specialty pharmacy management services program.

14 May 2015

New test could identify resistant tuberculosis faster

Tuberculosis (TB) disease rates in some parts of London are as high as in Sub-Saharan Africa, and drug-resistant strains are becoming increasingly common.

From Oxford Gene Technology 14 May 2015

MD Anderson researchers find significant clinical variations among liver cancer patients

Significant clinical variations exist among patients with the most common type of liver cancer called hepatocellular carcinoma (HCC), depending on the viral cause of the disease -hepatitis B virus (HBV) or hepatitis C virus (HCV). These differences suggest that hepatitis status should be considered when developing treatment plans for newly diagnosed patients, according to researchers at The University of Texas MD Anderson Cancer Center.

14 May 2015

Exposure to secondhand cannabis smoke causes mild intoxication

Researchers recruited seven people ages 18 to 45 who said they smoked cannabis at least twice per week and tested positive for THC, but who tested negative for other drugs, and 12 others in the same age range who said they had not used cannabis in the past six months and tested negative for cannabis, other drugs, and alcohol...

14 May 2015

Financial incentive programs help smokers kick the habit, finds Penn study

Four different financial incentive programs, each worth roughly $800 over six months, all help more smokers kick the habit than providing free access to behavioral counseling and nicotine replacement therapy. Further, the way in which equally-sized payouts are structured influences their effectiveness.

14 May 2015

Denali launched to discover, develop effective medicines for neurodegenerative diseases

Denali Therapeutics Inc., a new biotechnology company focused on developing effective therapies for neurodegenerative diseases, announced today that it has launched with an initial investment commitment of $217 million.

14 May 2015

Researchers submit patent application for drug that could destroy acute lymphoblastic leukemia

A patent application for a drug that could destroy the deadly childhood disease known as acute lymphoblastic leukemia — and potentially other cancers as well — has been submitted by researchers at Sandia National Laboratories, the University of Maryland and the MD Anderson Cancer Center in Houston.

14 May 2015

TSRI researchers find interferon beta protein as prime suspect in persistent viral infections

Interferon proteins are normally considered virus-fighters, but scientists at The Scripps Research Institute have found evidence that one of them, interferon beta (IFNβ), has an immune-suppressing effect that can help some viruses establish persistent infections.

14 May 2015

CNIO researchers identify new strategy to combat cancer

Scientists from the Spanish National Cancer Research Centre have discovered a new strategy to fight cancer, which is very different from those described to date. Their work shows for the first time that telomeres -- the structures protecting the ends of the chromosomes -- may represent an effective anti-cancer target: by blocking the TRF1 gene, which is essential for the telomeres, they have shown dramatic improvements in mice with lung cancer.

14 May 2015

Drugs News and Research

Study compares effectiveness of treatments for metastatic non-clear cell kidney cancers

Researchers discover how and where chromosome fragile sites occur in human DNA

CASI Pharmaceuticals reports net loss of $1.8 million for first quarter 2015

Drug combination lengthens lives of metastatic colorectal cancer patients

Vagus nerve stimulation effective in inhibiting cortical spreading depression

Mifepristone-eribulin combination clinically active in triple-negative breast cancer patients

Sheffield scientists to showcase novel medical discoveries during International Clinical Trials Day

Combination of contraceptive and cholesterol-lowering drugs kills cancer cells in a new way

Combination therapy provides promising results in patients with advanced non-small cell lung cancer

Scientists identify new molecules that destroy cancer cells, save healthy ones

Ground-breaking discovery could revolutionise lupus treatments

CARE Pharmacies, Aureus Health Services partner to improve patient care

New test could identify resistant tuberculosis faster

MD Anderson researchers find significant clinical variations among liver cancer patients

Exposure to secondhand cannabis smoke causes mild intoxication

Financial incentive programs help smokers kick the habit, finds Penn study

Denali launched to discover, develop effective medicines for neurodegenerative diseases

Researchers submit patent application for drug that could destroy acute lymphoblastic leukemia

TSRI researchers find interferon beta protein as prime suspect in persistent viral infections

CNIO researchers identify new strategy to combat cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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