Mouse Model News and Research

RSS

Scientists visualize action of immune cells in response to cancer cell proliferation

As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells.

28 Nov 2018

Early-life stress in mice hinders neuron development, causing attention problems

Women are roughly twice as likely as men to develop depression, anxiety and other stress-related problems, including difficulty with attention, and new research from Brown University neuroscientists sheds light on the biological reasons why.

28 Nov 2018

Lipid that helps keep skin cell turnover on track may aid in psoriasis

A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.

28 Nov 2018

Research may pave way for development of potent weapons against cancer

Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body's own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.

27 Nov 2018

CytoReason announces publication of new model for translating data from mouse models to human disease

CytoReason, developer of the world's first machine learning platform for human immune system cell-level simulation, today announces publication of a groundbreaking new model for translating data from mouse models to human disease.

27 Nov 2018

Genetic therapy may help children with Angelman syndrome to overcome seizures

Angelman syndrome is a genetic disease with no cure. Children grow up with severe intellectual disabilities and a range of other problems, arguably the worst of which are epileptic seizures. Now scientists at the UNC School of Medicine have found evidence that genetic therapy may prevent the enhanced seizure susceptibility.

21 Nov 2018

Scientists identify three genes responsible for recurrent molar pregnancies

A team of scientists at the Research Institute of the McGill University Health Centre and McGill University have identified three genes responsible for recurrent molar pregnancies, a rare complication that occurs when a non-viable pregnancy with no embryo implants in the uterus.

20 Nov 2018

DNA vaccine reduces levels of toxic proteins in Alzheimer’s model

Researchers have developed a new DNA vaccine that reduces the build-up of the toxic proteins associated with Alzheimer’s disease.

20 Nov 2018

Low-protein, high-carb diet may promote healthy brain ageing

Researchers at the University of Sydney have shown that a low-protein, high-carbohydrate diet may be the key to healthy brain ageing and longevity.

20 Nov 2018

Study warns that potential epigenetic therapy may boost lung cancer stem cells

Epigenetic therapies -- targeting enzymes that alter what genes are turned on or off in a cell -- are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant.

20 Nov 2018

Location matters for inflammation clearance

Health conditions that involve inflammation run the gamut, from multiple sclerosis and lupus to arthritis, diabetes, and cancer. While inflammation can serve as a normal response to help the body deal with injury or infection, problems arise when it persists, potentially harming surrounding tissues.

20 Nov 2018

Towards finding a druggable cancer target

It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer.

19 Nov 2018

Replacement of dysfunctional microglia has therapeutic potential for neurodegenerative diseases

A new study by researchers at Karolinska Institutet supports the theory that replacement of dysfunctional immune cells in the brain has therapeutic potential for neurodegenerative diseases like ALS and Alzheimer's disease.

19 Nov 2018

Researchers develop novel mouse model to study immunomodulatory therapies

Because mice do not respond to immunomodulatory drugs, preclinical therapeutic and safety studies of the effects of IMiDs have not been possible in existing types of mice.

19 Nov 2018

New model of FSHD could be useful to study effectiveness of experimental therapeutics

Facioscapulohumeral muscular dystrophy is the most prevalent dominantly inherited muscular dystrophy in the world. To date, there are no pharmacologic treatments available for the more than 850,000 people affected worldwide.

17 Nov 2018

Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission

During a heart attack the supply of oxygen to heart cells is decreased. This reduced oxygen level, called hypoxia, causes the cell's powerhouses, the mitochondria, to fragment, impairing cell function and leading to heart failure. Until now, few details were known on how this important process occurs.

17 Nov 2018

Mouse Model News and Research

Scientists visualize action of immune cells in response to cancer cell proliferation

Early-life stress in mice hinders neuron development, causing attention problems

Lipid that helps keep skin cell turnover on track may aid in psoriasis

Research may pave way for development of potent weapons against cancer

CytoReason announces publication of new model for translating data from mouse models to human disease

Genetic therapy may help children with Angelman syndrome to overcome seizures

Scientists identify three genes responsible for recurrent molar pregnancies

DNA vaccine reduces levels of toxic proteins in Alzheimer’s model

Low-protein, high-carb diet may promote healthy brain ageing

Study warns that potential epigenetic therapy may boost lung cancer stem cells

Location matters for inflammation clearance

Towards finding a druggable cancer target

Replacement of dysfunctional microglia has therapeutic potential for neurodegenerative diseases

Researchers develop novel mouse model to study immunomodulatory therapies

New model of FSHD could be useful to study effectiveness of experimental therapeutics

Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission

Gene editing could be used to halt kidney disease in patients with Joubert syndrome

Drug used to treat dizziness may slow down growth of triple-negative breast cancer

Study identifies potential therapeutic strategy for patients with clear cell renal cancer

Beneficial gut microbes metabolize high-fiber diet to improve heart health in mouse model

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News