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Transport of bacterial substrates through injectisome observed almost in real time

When attacking body cells, bacteria, such as salmonellae or Yersinia (plague pathogens), inject specific bacterial proteins through hollow, syringe-like structures - called injectisomes - into the host cells. These substances reprogram the cells and can thus overcome their defense. From then on, they can infiltrate the cells unhindered in large numbers, and trigger diseases such as typhus, plague, or cholera.

13 Dec 2013

Researchers show biophysical factors that contribute to the strength of heartbeat

The heart maintains a careful balancing act; too soft and it won't pump blood, but too hard and it will overtax itself and stop entirely. There is an optimal amount of strain that a beating heart can generate and still beat at its usual rate, once per second.

12 Dec 2013

Scientists devise method to measure forces in 3D tissues, living embryos

As embryonic tissue develops, cells push and pull on each other, and they must do so correctly for the tissue to develop properly. Now scientists at Harvard University have devised the first method to measure these forces in three-dimensional (3D) tissues and living embryos.

10 Dec 2013

Researchers develop new technique to cure human diseases caused by misfolded protein molecules

A team led by a longtime Oregon Health & Science University researcher has demonstrated in mice what could be a revolutionary new technique to cure a wide range of human diseases - from cystic fibrosis to cataracts to Alzheimer's disease - that are caused by "misfolded" protein molecules.

9 Dec 2013

Exposure to high-powered blue handheld laser devices can cause serious eye injuries

Exposure for even fractions of a second to high-powered blue handheld laser devices can cause serious eye injuries, according to a study recently released online in Ophthalmology, the journal of the American Academy of Ophthalmology. The researchers have concluded that the wide availability of these devices, which are often marketed as toys, could lead to an epidemic of ocular injuries, and greater public awareness and government intervention should be encouraged.

6 Dec 2013

Researchers identify gene involved in building circuitry that relays signals via brain

Using a powerful gene-hunting technique for the first time in mammalian brain cells, researchers at Johns Hopkins report they have identified a gene involved in building the circuitry that relays signals through the brain.

5 Dec 2013

Ventana now offers FDA-cleared image analysis and digital read application for IHC breast markers

Ventana Medical Systems, Inc., a member of the Roche Group, received 510(k) clearance from the U.S. Food and Drug Administration for the Companion Algorithm ER (SP1) image analysis algorithm used with the VENTANA iScan Coreo scanner running Virtuoso software. With this clearance, Ventana is now the only company in the industry offering a comprehensive portfolio of FDA-cleared image analysis algorithms and digital read applications for the five key immunohistochemistry breast markers.

5 Dec 2013

Biologists discover how nerve cells recycle tiny vesicles

University of Utah and German biologists discovered how nerve cells recycle tiny bubbles or "vesicles" that send chemical nerve signals from one cell to the next. The process is much faster and different than two previously proposed mechanisms for recycling the bubbles.

5 Dec 2013

New research offers fresh insights to drug designers searching for better pain treatments

In a technical tour de force, UC San Francisco scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

5 Dec 2013

Researchers examine how spindle apparatus self-organizes

Researchers at Waseda University in Japan have identified key information to help explain the formation of the "spindle apparatus", a structure required for cell division. Their findings shed light on the mechanisms behind "self-organization" - an essential characteristic of biological structures.

30 Nov 2013

Smartphone-based imaging could help physicians in remote locations to monitor patients' health

The latest episode in the American Chemical Society's (ACS') award-winning Global Challenges/Chemistry Solutions podcast series features an advance in smartphone-based imaging that could help physicians in resource-limited locations monitor their patients' health.

28 Nov 2013

Novel micro-catheter fluorescent dye method to treat aneurysm in deep brain

In March 2013, Eric Wagner told his wife to call 9-1-1 because he was feeling the worst that he had ever felt. He was rushed by EMS to University Hospitals (UH) Ahuja Medical Center, and then airlifted to UH Case Medical Center, where brain scans showed that he had a ruptured aneurysm, a leaking blister on a blood vessel that was letting blood flow into his brain and causing a stroke.

27 Nov 2013

Study uncovers mechanisms that allow stem cells to keep dividing in perpetuity

The blood stem cells that live in bone marrow are at the top of a complex family tree. Such stem cells split and divide down various pathways that ultimately produce red cells, white cells and platelets. These "daughter" cells must be produced at a rate of about one million per second to constantly replenish the body's blood supply.

27 Nov 2013

Researchers identify key immune cells that turn body's defenders against invading golden staph

When golden staph enters our skin it can identify the key immune cells and 'nuke' our body's immune response.

26 Nov 2013

Dysregulation of epigenetic marks may play role in chronic kidney disease, shows study

The research of physician-scientist Katalin Susztak, MD, PhD, associate professor of Medicine in the Renal Electrolyte and Hypertension Division, at the Perelman School of Medicine, University of Pennsylvania, strives to understand the molecular roots and genetic predisposition of chronic kidney disease.

26 Nov 2013

Waseda University researchers observe molecular motors that play critical role in chromosome transport

Researchers at Waseda University in Japan have for the first time directly observed the “molecular motor”, called Xkid, that plays a critical role in facilitating the proper alignment of chromosomes during cell division. Their findings are expected to contribute greatly to elucidating the molecular mechanisms of chromosome segregation, a key aspect of the development of certain medical disorders including cancer and birth defects.

25 Nov 2013

Penn researchers advance towards new DNA sequencing technique using graphene nanoribbon

The instructions for building all of the body's proteins are contained in a person's DNA, a string of chemicals that, if unwound and strung end to end, would form a sentence 3 billion letters long. Each person's sentence is unique, so learning how to read gene sequences as quickly and inexpensively as possible could pave the way to countless personalized medical applications.

19 Nov 2013

Patients treated with high-risk endoscopic procedure less likely to be admitted in hospital

Patients who seek treatment from physicians who more frequently perform a high-risk endoscopic procedure are less likely to be admitted to the hospital or require a repeat procedure. Unfortunately, 90 percent of physicians performing these procedures do very few of them.

19 Nov 2013

Olympus hosts fourth annual neuroimaging symposium on functional brain imaging with cellular resolution

Olympus is hosting its fourth annual neuroimaging symposium in conjunction with the 2013 meeting of the Society for Neuroscience (SfN) on Monday, November 11 in San Diego. The Olympus Neuroimaging Symposium will be held near the Convention Center at the San Diego Marriott Marquis and Marina, San Diego Ballroom – Salon A, beginning at 6:30pm. The symposium and reception are open to all media and SfN registered attendees.

From Evident Corporation - Life Sciences 8 Nov 2013

Peptide from cow's milk exhibits potent anticancer capability against human stomach cancer cell cultures

New research from a team of researchers in Taiwan indicates that a peptide fragment derived from cow's milk, known as lactoferricin B25 (LFcinB25), exhibited potent anticancer capability against human stomach cancer cell cultures.

8 Nov 2013

Microscope News and Research

Transport of bacterial substrates through injectisome observed almost in real time

Researchers show biophysical factors that contribute to the strength of heartbeat

Scientists devise method to measure forces in 3D tissues, living embryos

Researchers develop new technique to cure human diseases caused by misfolded protein molecules

Exposure to high-powered blue handheld laser devices can cause serious eye injuries

Researchers identify gene involved in building circuitry that relays signals via brain

Ventana now offers FDA-cleared image analysis and digital read application for IHC breast markers

Biologists discover how nerve cells recycle tiny vesicles

New research offers fresh insights to drug designers searching for better pain treatments

Researchers examine how spindle apparatus self-organizes

Smartphone-based imaging could help physicians in remote locations to monitor patients' health

Novel micro-catheter fluorescent dye method to treat aneurysm in deep brain

Study uncovers mechanisms that allow stem cells to keep dividing in perpetuity

Researchers identify key immune cells that turn body's defenders against invading golden staph

Dysregulation of epigenetic marks may play role in chronic kidney disease, shows study

Waseda University researchers observe molecular motors that play critical role in chromosome transport

Penn researchers advance towards new DNA sequencing technique using graphene nanoribbon

Patients treated with high-risk endoscopic procedure less likely to be admitted in hospital

Olympus hosts fourth annual neuroimaging symposium on functional brain imaging with cellular resolution

Peptide from cow's milk exhibits potent anticancer capability against human stomach cancer cell cultures

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