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Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.

5 May 2022

Oral Nirmatrelvir's effects on long COVID symptoms

In a recent study posted to the Research Square* preprint server, researchers at the University of California, San Francisco, examined the cases of three individuals who received nirmatrelvir/ritonavir antiviral therapy at different stages following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

4 May 2022

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

Scientists have discussed the possibilities of developing oral replicon-based mRNA vaccines against SARS-CoV-2.

4 May 2022

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Researchers reviewed the potential clinically relevant mechanisms by which microbiota and microbiota-derived metabolites influence the host immune responses to SARS-CoV-2 infection.

3 May 2022

Study suggests aerosol transmission of antibodies may contribute to host protection against SARS-CoV-2

A new study has addressed the previously mentioned research gap and has investigated the possibility of transfer of aerosol containing SARS-CoV-2-specific antibodies between vaccinated and non-immune hosts

3 May 2022

The generation of SARS-CoV-2 virus-like particles in insect cells

Researchers have reported the development of a promising COVID-19 vaccine candidate which is based on SARS-CoV-2 VLPs, derived from the co-expression of the spike, membrane, and envelope structural proteins in the baculovirus expression system.

2 May 2022

Roswell Park's nursing teams share research at 47th Annual Congress of the Oncology Nursing Society

Several nursing teams from Roswell Park Comprehensive Cancer Center were invited to share their research at the 47th Annual Congress of the Oncology Nursing Society, which is underway in Anaheim, California, and continues through May 1, 2022.

29 Apr 2022

Poor asthma control triggered by SARS-CoV-2

In a new study, researchers noted that COVID-19 could trigger poor pediatric asthma control.

29 Apr 2022

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

Researchers surveilled coronaviruses found in bats via targeted genomic sequencing.

29 Apr 2022

Gum Health Day 2022 calls for prevention, early detection, and effective treatment of gum diseases

"Treat your gums" is the slogan for Gum Health Day 2022, a worldwide awareness campaign organised by the European Federation of Periodontology (EFP).

28 Apr 2022

Penn scientists discover how one inflammatory disorder increases susceptibility to another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.

27 Apr 2022

Phase I/II trials of new paratyphoid vaccine begin in Oxford

The University of Oxford in collaboration with the University of Maryland School of Medicine has begun recruiting for a Phase I/II trial of a new paratyphoid vaccine in human volunteers in Oxford - with first vaccinations taking place today (Tuesday).

26 Apr 2022

New drug combo emerges as a potential candidate for oral pericoital contraception

A new combination of drugs has emerged as a "promising candidate" for an on-demand contraceptive pill, suggests preliminary research published online in the journal BMJ Sexual & Reproductive Health.

26 Apr 2022

Eradicating Polio; What's it going to take?

In this interview, we speak to Judith Diment from Rotary’s International PolioPlus Committee about the incredible work they are doing to help eradicate polio worldwide.

26 Apr 2022

World Immunization Week 2022: Striving for a Long Life for All with the International Vaccine Institute

As part of World Immunization Week 2022, News Medical speaks to the International Vaccine Institute about their fight against vaccine inequity, as well as what a “Long Life for All” means to them.

25 Apr 2022

Quercetin and other plant flavonols show anti-SARS-CoV-2 activity

A new study discusses the potential of certain plant compounds to block SARS-CoV-2 replication within host cells.

24 Apr 2022

Study demonstrates that a low-dose, bivalent, unmodified mRNA vaccine against SARS-CoV-2 is highly efficacious

Researchers compared the efficiency of monovalent and bivalent mRNA vaccines against SARS-CoV-2.

22 Apr 2022

Dentures may negatively impact a person's overall nutrition, research suggests

Dentures may have a potentially negative impact on a person's overall nutrition, according to new research from Regenstrief Institute and Indiana University School of Dentistry.

21 Apr 2022

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Researchers developed an immunoantiviral, NanoSTING, and demonstrated its broad-spectrum antiviral properties in hamsters and mice.

21 Apr 2022

Why cheap, older drugs that might treat covid never get out of the lab

In March 2020, Dr. Joseph Vinetz left the contemplative world of his Yale University infectious-disease laboratory and plunged into the covid ward at Yale New Haven Hospital, joining an army of health care workers who struggled to treat the deadly viral disease.

19 Apr 2022

Oral News and Research

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

Oral Nirmatrelvir's effects on long COVID symptoms

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Study suggests aerosol transmission of antibodies may contribute to host protection against SARS-CoV-2

The generation of SARS-CoV-2 virus-like particles in insect cells

Roswell Park's nursing teams share research at 47th Annual Congress of the Oncology Nursing Society

Poor asthma control triggered by SARS-CoV-2

Study evaluates hybridization probe capture for enriching coronavirus genomic material in bat oral and rectal swabs

Gum Health Day 2022 calls for prevention, early detection, and effective treatment of gum diseases

Penn scientists discover how one inflammatory disorder increases susceptibility to another

Phase I/II trials of new paratyphoid vaccine begin in Oxford

New drug combo emerges as a potential candidate for oral pericoital contraception

Eradicating Polio; What's it going to take?

World Immunization Week 2022: Striving for a Long Life for All with the International Vaccine Institute

Quercetin and other plant flavonols show anti-SARS-CoV-2 activity

Study demonstrates that a low-dose, bivalent, unmodified mRNA vaccine against SARS-CoV-2 is highly efficacious

Dentures may negatively impact a person's overall nutrition, research suggests

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Why cheap, older drugs that might treat covid never get out of the lab

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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