Oral News and Research

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Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

Study shows link between oral microbiome and naturally occurring alveolar bone loss

It is becoming increasingly clear that the human microbiome – the collection of bacteria, viruses and fungi that live on and within us – significantly contributes to our health.

17 Feb 2022

Estonian Microbiome Project demonstrates the impact of long-term antibiotic use on the microbiome

Estonian Microbiome Project, using electronic health data from more than 2500 biobank participants finds long-term antibiotic usage, independent from recent administration, has an impact on the microbiome, partly explaining the common bacterial signatures overlapping between diseases.

16 Feb 2022

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

A recent study posted to the medRxiv* preprint server reported the phase one pharmacokinetic and safety data of nirmatrelvir/ritonavir to facilitate its rapid progression to the last stages of clinical trials in coronavirus disease 2019 (COVID-19) patients with mild to moderate disease.

14 Feb 2022

Antihistamines may offer hope for long COVID patients

Researchers offer hope that an inexpensive over-the-counter medication could improve long COVID symptoms for a large proportion of these patients.

14 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

Scientists decipher molecular cause of cerebral venous thrombosis

Cerebral venous thrombosis is a rare, often severe disease that has been brought to public attention by the Covid 19 pandemic. A research group from Würzburg has now succeeded for the first time in deciphering a molecular cause of this disease.

11 Feb 2022

Direct oral anti-coagulants less likely to result in major bleeding after rare, fatal stroke

Direct oral anti-coagulant (anti-clotting) (DOAC) medications that target a single clotting factor work just as well to prevent future clots as the older, less-specific medication warfarin.

11 Feb 2022

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

A study published on the bioRxiv* preprint server evaluates molnupiravir against a panel of relevant VOCs using three efficacy models: primary human airway epithelium organoids, a ferret model of upper respiratory disease, and a Roborovski dwarf hamster model for severe COVID-19.

9 Feb 2022

How SARS-CoV-2 infection progresses throughout the respiratory system

Researchers discuss the progression of SARS-CoV-2 infection throughout the respiratory epithelium.

9 Feb 2022

Study explores SARS-CoV-2 manifestations and related hospitalizations in infants

A new study examined the clinical manifestations of SARS-CoV-2 infections, disease severity, and related hospitalization in infants in Canada.

8 Feb 2022

Two peanut allergy treatments for children found to be highly effective at inducing remission

Researchers have discovered two peanut allergy treatments for children that are both highly effective at inducing remission.

7 Feb 2022

A disabled activist speaks out about feeling ‘disposable’

In early January, one of the country's top public health officials went on national television and delivered what she called "really encouraging news" on covid-19: A recent study showed that more than three-fourths of fatalities from the omicron variant of the virus occurred among people with several other medical conditions.

4 Feb 2022

Spice could play a key role in reducing salt intake among seniors

Montero, M.L., et al. (2022) Saltiness perception in white sauce formulations as tested in older adults. Food Quality and Preference. doi.org/10.1016/j.foodqual.2022.104529.

3 Feb 2022

Exploring human milk oligosaccharides as a method of COVID-19 prevention

New research was conducted to ascertain whether antiviral and immunomodulatory activities of human milk oligosaccharides can be efficacious in the prevention and treatment against COVID-19.

3 Feb 2022

Red foxes susceptible to SARS-CoV-2 infection

Working towards the aim to determine the SARS-CoV-2 susceptibility of common wildlife species, the researchers in the United States have found that red fox (Vulpes vulpes) can experimentally become infected with SARS-CoV-2 and can shed virus in its oral and nasal secretions.

3 Feb 2022

Study reveals a direct correlation between fat browning and consumption of flavan 3-ols

In cold conditions, brown adipose tissue (BAT) or brown fat generates heat to keep the body warm. Compared with white adipose tissue, BAT has more mitochondria - subcellular organelles associated with energy production - which allows it to burn calories and produce heat by activating the mitochondrial uncoupling protein 1 (Ucp-1).

2 Feb 2022

Oral contraceptive use and tubal ligation linked with lower levels of biomarker for ovarian aging

The long-term use of oral contraceptives and certain methods of tubal ligation (TL) were associated with lower levels of a biomarker for ovarian aging, suggesting an increased risk for early menopause, according to preliminary research by University of Massachusetts Amherst epidemiologists.

2 Feb 2022

Research supports the need for a 3rd mRNA COVID vaccine in patients taking immunosuppressants

New research posted to the medRxiv* preprint server finds patients with immune-mediated inflammatory diseases undergoing anti-TNF therapy had the greatest reduction of antibody levels three months after vaccination. In addition, they had weaker neutralization responses towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

1 Feb 2022

Oral News and Research

Ensitrelvir, a novel SARS-CoV-2 antiviral

Study shows link between oral microbiome and naturally occurring alveolar bone loss

Estonian Microbiome Project demonstrates the impact of long-term antibiotic use on the microbiome

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

Antihistamines may offer hope for long COVID patients

Nitazoxanide shows promise for COVID-19 treatment in animal model

Scientists decipher molecular cause of cerebral venous thrombosis

Direct oral anti-coagulants less likely to result in major bleeding after rare, fatal stroke

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

How SARS-CoV-2 infection progresses throughout the respiratory system

Study explores SARS-CoV-2 manifestations and related hospitalizations in infants

Two peanut allergy treatments for children found to be highly effective at inducing remission

A disabled activist speaks out about feeling ‘disposable’

Spice could play a key role in reducing salt intake among seniors

Exploring human milk oligosaccharides as a method of COVID-19 prevention

Red foxes susceptible to SARS-CoV-2 infection

Study reveals a direct correlation between fat browning and consumption of flavan 3-ols

Oral contraceptive use and tubal ligation linked with lower levels of biomarker for ovarian aging

Research supports the need for a 3rd mRNA COVID vaccine in patients taking immunosuppressants

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