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DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis" which reported that microscopic imaging, immunocytochemistry, wound healing assay, caspase-cleaved cytokeratin 18 CytoDeath ELISA assay, immunofluorescence labeling assays for apoptosis, hypoxia, Western Blotting, Tunnel assay, measurement of 5-HT secretion by carbon fiber amperometry assay, quantitative methylation-specific PCR, morphologic changes, cell viability, apoptosis activity and the expression levels of phospho-Akt1, Akt1, HIF-1α, PI3K, p21, CAIX, 5-HT, phospho-mTOR, and mTOR in xenografts derived from typical H727 and atypical H720 BC cell lines.

28 Aug 2021

Mystery of roe deer embryonic diapause revealed

Everyone is familiar with the roe deer, either from crossword puzzles or from real-life encounters during a jog or a hike in the forest: majestic creatures with elegant big black eyes.

28 Aug 2021

PETA scientists come up with state-of-the-art tools to implement animal-free research

This week marks the 11th World Congress on Alternatives and Animal Use in the Life Sciences, and the thousands of scientists attending this year's virtual conference will hear from PETA scientists on matters ranging from scientific and ethical concerns regarding inflicting permanent brain damage on primates to toxicity testing in rabbits.

28 Aug 2021

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

The AIDS Clinical Trials Group, the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies.

27 Aug 2021

Olympus Announces First Organoid Conference to Support Stem Cell Research

Olympus is proud to announce its first Olympus Organoid Conference—Think Deep, See Deeper, which will be held virtually on Sept. 7–9, 2021.

From Evident Corporation - Life Sciences 27 Aug 2021

Aptamer Group and Bio-Works Technologies partner to enable improved solutions for gene therapy manufacturing

Aptamer Group Ltd and Bio-Works Technologies AB today announce that they have entered into an agreement to co-develop a new affinity resin.

From Aptamer Group 26 Aug 2021

Large UK study examines impact of Delta variant on viral burden and vaccine effectiveness

Now, a new study published on the medRxiv* preprint server focused on determining the effectiveness of the BNT162b2, ChAdOx1, and mRNA-1273 vaccines by conducting SARS-CoV-2 PCR-positive tests.

26 Aug 2021

New artificial blood vessel platform for predicting organ transplant rejection

Organ transplantation involves the transplantation of organs from donors as a means to treat disease or injury, but there is a shortage of organs available for donation compared to the demand for organ transplantation.

25 Aug 2021

Persistence of Anti-PF4 levels in VITT patients four months after AstraZeneca COVID-19 vaccine

A study published on medRxiv* preprint server reported the over-time changes in the ability of the serum to activate platelets in vitro.

25 Aug 2021

SARS-CoV-2 Delta likely to acquire resistance to wild-type spike vaccines

A new study published on the preprint server bioRxiv* explores the mechanism of the Delta variant's high infectivity and suggests a plausible pathway by which the Delta variant could escape from vaccine-induced immunity.

24 Aug 2021

Peptoids could one day cure or prevent herpes, COVID-19

In addition to antibodies and white blood cells, the immune system deploys peptides to fight viruses and other pathogens.

24 Aug 2021

Synthetic SARS-CoV-2 vs. SARS-CoV-2

Though vaccination efforts are underway in most countries, there are still limited options for treating COVID-19. Now, researchers at Penn State designed a new COVID-19 therapy that uses a defective synthetic version of the SARS-CoV-2 virus to interfere with the actual virus's replication.

23 Aug 2021

Study discovers lagging chromosomes as one of the major causes of infertility

Why do women over 35 have more difficulty getting pregnant? After discovering one of the causes of age-related female infertility, researchers at the University of Montreal Hospital Research Centre suggest that it will be possible in the future to improve the quality of the eggs of older patients by intervening on the cell cycle level.

23 Aug 2021

Study identifies a novel potential biomarker for hepatocellular carcinoma

Aging-US published "Comprehensive analysis of the competing endogenous circRNA-lncRNA-miRNA-mRNA network and identification of a novel potential biomarker for hepatocellular carcinoma" which reported that there is still a lack of comprehensive analysis of the circular RNA -long non-coding RNA -miRNA-mRNA ceRNA network in hepatocellular carcinoma.

23 Aug 2021

Study investigates the effects of calycosin on breast cancer cell progression

Aging-US published "Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1" which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited proliferation, migration, and invasion by T47D and MCF-7 breast cancer cells by downregulating basic leucine zipper ATF-like transcription factor expression.

23 Aug 2021

Human milk oligosaccharides may help treat or prevent bacterial infections in newborns and adults

Bacteria known as group B Streptococcus (GBS) are a common cause of blood infections, meningitis and stillbirth in newborns. Although GBS infections can often be treated or prevented with antibiotics, the bacteria are becoming increasingly resistant.

23 Aug 2021

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New drugs are intended to help stop viral zoonoses - infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

20 Aug 2021

A systematic review of in vitro studies evaluating the efficacy of mouth rinses on SARS-CoV-2

A new study aims to evaluate the current body of published in vitro research related to the efficacy of mouthwashes in preventing SARS-CoV-2 transmission.

20 Aug 2021

3D-printed tumors potentially next step in personalized medicine

Scientists at Tel Aviv University have successfully printed an entire active and viable brain tumor using a three-dimensional or 3D printer for the first time.

20 Aug 2021

in vitro News and Research

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Combination therapy disables PI3K/Akt/mTOR pathway and induces apoptosis in carcinoid syndrome

Mystery of roe deer embryonic diapause revealed

PETA scientists come up with state-of-the-art tools to implement animal-free research

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

Olympus Announces First Organoid Conference to Support Stem Cell Research

Aptamer Group and Bio-Works Technologies partner to enable improved solutions for gene therapy manufacturing

Large UK study examines impact of Delta variant on viral burden and vaccine effectiveness

New artificial blood vessel platform for predicting organ transplant rejection

Persistence of Anti-PF4 levels in VITT patients four months after AstraZeneca COVID-19 vaccine

SARS-CoV-2 Delta likely to acquire resistance to wild-type spike vaccines

Peptoids could one day cure or prevent herpes, COVID-19

Synthetic SARS-CoV-2 vs. SARS-CoV-2

Study discovers lagging chromosomes as one of the major causes of infertility

Study identifies a novel potential biomarker for hepatocellular carcinoma

Study investigates the effects of calycosin on breast cancer cell progression

Human milk oligosaccharides may help treat or prevent bacterial infections in newborns and adults

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

A systematic review of in vitro studies evaluating the efficacy of mouth rinses on SARS-CoV-2

3D-printed tumors potentially next step in personalized medicine

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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