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Study findings can help develop new drugs for ischemia

Russian scientists investigated the role of opioid receptors in protecting the heart from coronary disease: the lack of its blood supply.

25 Feb 2019

Researchers discover origin of resistance to lung cancer

For treating cancer, drugs based on molecules known as tyrosine kinase inhibitors are sometimes used. One such tyrosine kinase inhibitor, called osimertinib, has been used to treat EGFR-mutated lung cancer with a certain degree of efficacy.

25 Feb 2019

Fat cells exhibit circadian rhythms affecting critical metabolic functions, study finds

Fat cells in the human body have their own internal clocks and exhibit circadian rhythms affecting critical metabolic functions, new research in the journal Scientific Reports, finds.

25 Feb 2019

Neuron-derived estrogen key to making memories

Estrogen in the brain is important to keep neurons communicating and memories being made, scientists report.

25 Feb 2019

Researchers engineer 'antibody-like' T cell receptors to combat deadly virus

Researchers have engineered "antibody-like" T cell receptors that can specifically stick to cells infected with cytomegalovirus, or CMV, a virus that causes lifelong infection in more than half of all adults by age 40.

23 Feb 2019

New technology platform digitally counts growth factors in single cells

Whether healthy or diseased, human cells exhibit behaviors and processes that are largely dictated by growth factor molecules, which bind to receptors on the cells. For example, growth factors tell the cells to divide, move, and when to die--a process known as apoptosis.

23 Feb 2019

Researchers develop highly sensitive cell model to study complex effects of anti-inflammatory drugs

Drugs such as ibuprofen or aspirin that relieve pain and lower fever are among the most frequently used drugs worldwide. They are used above all for the treatment of inflammatory reactions. However, in spite of their indisputable effectiveness and frequent use, we do not yet fully understand the underlying mechanisms of these drugs.

23 Feb 2019

Study unravels genetic basis of hypertrophic cardiomyopathy cases in Finland

One third of hypertrophic cardiomyopathy cases in Finland are caused by one of the four major mutations, a new study from the University of Eastern Finland and Kuopio University Hospital shows.

23 Feb 2019

Researchers unravel how specific intestinal microbiota amplify inflammatory reactions in the lungs

The composition of the microbiome - the countless bacteria, fungi and viruses that colonize our body surface, skin, intestines or lungs - makes a decisive contribution to human health or disease.

23 Feb 2019

Novel MRI sensor can peer deep into the brain to detect intracellular calcium activity

Calcium is a critical signaling molecule for most cells, and it is especially important in neurons. Imaging calcium in brain cells can reveal how neurons communicate with each other; however, current imaging techniques can only penetrate a few millimeters into the brain.

22 Feb 2019

'Holy herb' (Yerba santa) identified as a potential treatment for Alzheimer’s disease

Yerba santa, also known as the ‘Holy Herb’, may have important implications for patients with Alzheimer’s disease.

22 Feb 2019

The gene-edited twins born in China may have altered cognition and memory

A new study has fuelled further concerns over the controversial gene-editing experiment that was performed in China last year.

22 Feb 2019

Study finds out similarity in function between healthy retina cell and tumor cell

How is a healthy retina cell like a tumor cell? It hijacks an energy-producing chemical reaction to churn out molecular building blocks. When tumor cells do it, they use the building blocks to make cancer grow and spread. But when retina cells do it, they renew photoreceptor membranes that keep our vision sharp.

22 Feb 2019

Akna protein plays a key role in the regulation of neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine.

22 Feb 2019

New cellular atlas could provide a deeper insight into blinding diseases

When it comes to understanding how neurons connect to form circuits in the brain, scientists for decades have turned to the retina of the humble laboratory mouse as an ideal model organism. But as a model for vision and vision-related diseases, mice simply aren't equipped.

22 Feb 2019

Researchers identify origin of immune cell that helps form healthy heart valves

UCLA researchers have identified for the first time the origin of an immune cell that plays a critical role in the formation of healthy heart valves. The findings could pave the way for new treatments for heart valve disorders, which can be caused by congenital defects, aging or disease.

22 Feb 2019

New study finds how high-fat diets fuel colorectal cancer growth

As cancer death rates drop overall, doctors have noted a frightening anomaly: deaths from colorectal cancer in people under 55 appear to be creeping up. According to the American Cancer Society, deaths in this younger group increased by 1 percent between 2007 and 2016.

22 Feb 2019

Researchers uncover interspecies communication between gut bacteria and host

Bacteria in the gut do far more than help digest food in the stomachs of their hosts, they can also tell the genes in their mammalian hosts what to do.

22 Feb 2019

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

An increase in the incidence and mortality rate of cancer has been noted worldwide, especially for lung cancer.

22 Feb 2019

New device allows scientists to reproduce blow effects on the heart in lab

A blow to the chest can have highly contrasting effects. For instance, some baseball players have died after being hit in the chest by a baseball, while patients undergoing fatal cardiac tachyarrhythmias have been saved by an appropriately timed thump to the chest.

22 Feb 2019