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Research points to new target for treating periodontitis

T cells help fight off infection, but they can go overboard. A new study led by researchers at the University of Pennsylvania School of Dental Medicine and the National Institutes of Health shows that a subset of T cells contributes to the problematic inflammation and bone loss that is associated with periodontitis, a severe form of gum disease.

17 Oct 2018

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

A group of Massachusetts General Hospital investigators is proposing that targeting immune checkpoints - molecules that regulate the activity of the immune system - in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

17 Oct 2018

Mice study shows antibiotics are not always necessary to cure sepsis

Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice.

17 Oct 2018

Chronic sleep disruption in early adult life accelerates AD-related tau pathology

Lack of sleep during adolescence and early adulthood accelerates Alzheimer’s disease-related tau pathology, finds a study of male and female mice published in JNeurosci.

17 Oct 2018

Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration

Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier--which keeps large molecules in the blood from entering the brain--becomes abnormally permeable, allowing fibrin to leak into the brain and trigger inflammation.

16 Oct 2018

Study identifies molecular switch that controls fate of milk-producing breast cells

A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

15 Oct 2018

Study: Neurons regulating reproductive hormone release have different activity in epileptic mice

Mice with epilepsy have altered patterns of neuron activity in the portion of the brain that controls the reproductive endocrine system, University of Illinois researchers report in a new study. Furthermore, the differences in neuron activity in female mice fluctuate across the reproductive cycle, the team found.

15 Oct 2018

Findings offer new insight into early changes that occur during AD pathology

Alzheimer's disease (AD) is the most common form of dementia, involving memory loss and a reduction in cognitive abilities.

12 Oct 2018

Study suggests new approach to treat life-threatening blood disorder in children

Pediatric researchers studying the life-threatening blood disorder Fanconi anemia have devised a method to block the abnormal biological signals that drive the disease.

12 Oct 2018

New findings could benefit patients with triple-negative breast cancer

About 15 percent of breast cancers are classified as triple-negative, lacking receptors for estrogen, progesterone, and Her2.

12 Oct 2018

New transgenic mouse model sheds light on biological causes of Parkinson's disease

Parkinson's disease is a neurodegenerative disorder that presents clinically with abnormal movement and tremors at rest.

12 Oct 2018

Vagus nerve stimulation can reverse brain inflammation after surgery, mice study shows

For adults over age 65, surgical complications can dampen not only their physical health but also their mental sharpness, with more than half of high-risk cases declining into delirium.

12 Oct 2018

Drug treatment at a young age could help reverse autism-like behavior in tuberous sclerosis

New research on autism has found, in a mouse model, that drug treatment at a young age can reverse social impairments. But the same intervention was not effective at an older age.

10 Oct 2018

New 3D imaging technique helps track satiety hormone

Many overweight people lack the feeling of being full. It was long thought that this was due to the disrupted transport of the satiety hormone leptin to the brain.

9 Oct 2018

New genome editing tool used to heal genetic disease

Parents of newborns may be familiar with the metabolic disorder phenylketonuria: in Switzerland, all newborn babies are screened for this genetic disease.

8 Oct 2018

Researchers use CRISPR-Cas9 to prevent congenital disease in utero

Researchers have successfully used prenatal gene editing (CRISPR-Cas9) to prevent a fatal metabolic disorder in an animal model.

8 Oct 2018

Study shows possibility of using PET imaging to manage chronic liver diseases

While liver biopsies are powerful and reliable, they are also invasive, painful, limited and subject to complications. These effects may soon be a thing of the past for some patients thanks to new research showing PET imaging with the 18F-FAC radiotracer can be used as a non-invasive substitute. The study is featured in the October issue of The Journal of Nuclear Medicine.

5 Oct 2018

Periodontal disease may be an initiator of Alzheimer's

Long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer's disease in humans, according to a new study from researchers at the University of Illinois at Chicago.

4 Oct 2018

Natural compound found in grapes may protect against cancer

Lung cancer is the deadliest form of cancer in the world, and 80% of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed.

3 Oct 2018

Newly discovered protein shown to cause amyloid-beta plaques in Alzheimer's

Scientists have discovered that a potassium channel called KCNB1 can trigger the formation of amyloid-beta plaques seen in Alzheimer's disease.

2 Oct 2018

Mouse Model News and Research

Research points to new target for treating periodontitis

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Mice study shows antibiotics are not always necessary to cure sepsis

Chronic sleep disruption in early adult life accelerates AD-related tau pathology

Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration

Study identifies molecular switch that controls fate of milk-producing breast cells

Study: Neurons regulating reproductive hormone release have different activity in epileptic mice

Findings offer new insight into early changes that occur during AD pathology

Study suggests new approach to treat life-threatening blood disorder in children

New findings could benefit patients with triple-negative breast cancer

New transgenic mouse model sheds light on biological causes of Parkinson's disease

Vagus nerve stimulation can reverse brain inflammation after surgery, mice study shows

Drug treatment at a young age could help reverse autism-like behavior in tuberous sclerosis

New 3D imaging technique helps track satiety hormone

New genome editing tool used to heal genetic disease

Researchers use CRISPR-Cas9 to prevent congenital disease in utero

Study shows possibility of using PET imaging to manage chronic liver diseases

Periodontal disease may be an initiator of Alzheimer's

Natural compound found in grapes may protect against cancer

Newly discovered protein shown to cause amyloid-beta plaques in Alzheimer's

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