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Customizing Genetically Engineered Models for Specific Research Applications

In this interview conducted at SfN 2018, Philip Dubé from Taconic Biosciences, goes into detail about genetically engineered models and their importance in understanding neurodegenerative diseases.

From Taconic Biosciences, Inc. 4 Dec 2018

Using nanocarrier-delivered microRNA to target sepsis

One in three patients who die in the U.S. dies of sepsis, according to the Centers for Disease Control and Prevention. It is one of the leading causes of death in intensive care units and, with an estimated price tag of $20 billion in 2011, the most expensive condition that hospitals treat.

3 Dec 2018

Scientists alleviate schizophrenic symptoms in mice

Despite extensive research efforts, schizophrenia remains one of the least understood brain disorders. One promising area of research is in receptors on the surfaces of brain cells that help sense growth factors.

30 Nov 2018

Triple combination cancer immunotherapy improves survival in mouse model of melanoma

Adoptive cell transfer is a promising cancer immunotherapy that involves isolating T cells from cancer patients that are capable of targeting their tumor, selecting the more active T cells and expanding those in the lab, and then transfusing them back into patients.

30 Nov 2018

Curry spice may improve exercise intolerance related to heart failure

New research suggests that curcumin, a main ingredient in curry, may improve exercise intolerance related to heart failure. The study is published ahead of print in the Journal of Applied Physiology.

29 Nov 2018

New method could improve outcome of leukemia patients receiving stem-cell transplants

Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue - often with fatal consequences.

28 Nov 2018

Scientists visualize action of immune cells in response to cancer cell proliferation

As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells.

28 Nov 2018

Early-life stress in mice hinders neuron development, causing attention problems

Women are roughly twice as likely as men to develop depression, anxiety and other stress-related problems, including difficulty with attention, and new research from Brown University neuroscientists sheds light on the biological reasons why.

28 Nov 2018

Lipid that helps keep skin cell turnover on track may aid in psoriasis

A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.

28 Nov 2018

Research may pave way for development of potent weapons against cancer

Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body's own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.

27 Nov 2018

CytoReason announces publication of new model for translating data from mouse models to human disease

CytoReason, developer of the world's first machine learning platform for human immune system cell-level simulation, today announces publication of a groundbreaking new model for translating data from mouse models to human disease.

27 Nov 2018

Genetic therapy may help children with Angelman syndrome to overcome seizures

Angelman syndrome is a genetic disease with no cure. Children grow up with severe intellectual disabilities and a range of other problems, arguably the worst of which are epileptic seizures. Now scientists at the UNC School of Medicine have found evidence that genetic therapy may prevent the enhanced seizure susceptibility.

21 Nov 2018

Scientists identify three genes responsible for recurrent molar pregnancies

A team of scientists at the Research Institute of the McGill University Health Centre and McGill University have identified three genes responsible for recurrent molar pregnancies, a rare complication that occurs when a non-viable pregnancy with no embryo implants in the uterus.

20 Nov 2018

DNA vaccine reduces levels of toxic proteins in Alzheimer’s model

Researchers have developed a new DNA vaccine that reduces the build-up of the toxic proteins associated with Alzheimer’s disease.

20 Nov 2018

Low-protein, high-carb diet may promote healthy brain ageing

Researchers at the University of Sydney have shown that a low-protein, high-carbohydrate diet may be the key to healthy brain ageing and longevity.

20 Nov 2018

Study warns that potential epigenetic therapy may boost lung cancer stem cells

Epigenetic therapies -- targeting enzymes that alter what genes are turned on or off in a cell -- are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant.

20 Nov 2018

Location matters for inflammation clearance

Health conditions that involve inflammation run the gamut, from multiple sclerosis and lupus to arthritis, diabetes, and cancer. While inflammation can serve as a normal response to help the body deal with injury or infection, problems arise when it persists, potentially harming surrounding tissues.

20 Nov 2018