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Imatinib-related symptom burden linked to adherence in Indian CML patients

Research shows low adherence to imatinib in Indian patients with chronic myeloid leukaemia, with an association between nonadherence and worse symptom burden related to treatment.

21 Apr 2016

Strength training lowers odds of death in older adults

Older adults who met twice-weekly strength training guidelines had lower odds of dying in a new analysis by researchers at Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center and Columbia University. The study is the first to demonstrate the association in a large, nationally representative sample over an extended time period, particularly in an older population.

20 Apr 2016

Specific oral microbiome linked to pancreatic cancer risk

The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment. This is the main finding of a study led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center to be presented April 19 in New Orleans at the annual meeting of the American Association for Cancer Research.

20 Apr 2016

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Researchers from VIB-UGent reveal that adult circulating monocytes that get access to the macrophage niche in the liver or the lung can acquire identical tissue-specific macrophage functions and self-maintenance capacities as macrophages of embryonic origin.

20 Apr 2016

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy.

20 Apr 2016

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

The immunotherapy drug nivolumab has become the first to show a survival benefit in head and neck cancer, after a major international trial found that it was more effective than standard chemotherapy.

20 Apr 2016

DKFZ researchers develop new methods to study disease-relevant changes in production of oxidants

There are many false beliefs and myths about the role of oxidants and antioxidants in the human body. Traditionally, oxidants are presented as harmful and antioxidants as health-promoting. However, scientists have known for many years that endogenous oxidants are essential chemical messengers that help keep up the functions of the organism.

20 Apr 2016

Researchers evaluate TBI-associated risk factors in older adults

Traumatic brain injury (TBI), a leading cause of death and disability, has become so common in recent times that it has been called a "silent epidemic." And because older adults are more likely to suffer TBI, have worse outcomes, and are less likely to survive their injury than younger adults, older adults are considered a "silent population" within this epidemic.

20 Apr 2016

Herceptin drugs for breast cancer linked with increased risk of congestive heart failure

Breast cancer patients undergoing treatment with trastuzumab-containing regimens should be monitored for heart damage regardless of age. This is among the findings of a new study from the Peter Munk Cardiac Centre, the Institute for Clinical Evaluative Sciences (ICES) and the Ted Rogers Centre for Heart Research, University Health Network.

20 Apr 2016

Aspirin use linked with reduced risk of developing bile duct cancer

A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. The results are published in Hepatology.

20 Apr 2016

New therapy strategy for liver disease shows initial measureable success with norUrso

The new therapy strategy for primary sclerosing cholangitis, a liver disease that at present still cannot be cured with medication, shows initial measureable success with the nor-ursodeoxycholic acid (norUrso).

19 Apr 2016

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

If genes form the body's blueprint, then the layer of epigenetics decides which parts of the plan get built. Unfortunately, many cancers hijack epigenetics to modulate the expression of genes, thus promoting cancer growth and survival.

19 Apr 2016

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Asthma is an enormous public health problem that continues to grow larger, in part because scientists don't fully understand how it is caused. Existing therapies don't cure the disease and often don't even significantly alleviate the symptoms. Now, scientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.

19 Apr 2016

High dietary saturated fat intake may lead to prostate cancer aggressiveness

Eating a diet higher in saturated fat, a type of fat found commonly in foods such as fatty beef and cheese, was linked to more aggressive prostate cancer, a study by University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators has found. The preliminary results were presented Monday, April 18 at the American Association for Cancer Research Annual Meeting in New Orleans.

19 Apr 2016

Animal study links female resilience to renal ischemia with protective effects of estrogen

Kidney transplantation outcomes are adversely affected by ischemia-reperfusion injury, which occurs as a result of blood flow restrictions during the reperfusion stage of transplant surgery.

19 Apr 2016

Specific intake levels of xanthohumol reduces obesity, cholesterol and elevated glucose

A recent study at Oregon State University has identified specific intake levels of xanthohumol, a natural flavonoid found in hops, that significantly improved some of the underlying markers of metabolic syndrome in laboratory animals and also reduced weight gain.

19 Apr 2016

Exposure to homicide during pregnancy linked to increased risk of prematurity, low birth weight

In a recent paper published in the Journal of Development Economics, researchers Professor Marco Manacorda (Queen Mary University of London) and Dr Martin Foureaux Koppensteiner (University of Leicester) focused on evidence from the exposure of day-to-day violence in Brazil by analysing the birth outcomes of children whose mothers were exposed to local violence, as measured by homicide rates in small Brazilian municipalities and the neighbourhoods of the city of Fortaleza.

18 Apr 2016

More than half of U.S. adults believe today's kids have diminished emotional and mental health

More than half of adults believe children today are more stressed, experience less quality family time and have worse mental and emotional health than children in past generations, according to the C.S. Mott Children's Hospital National Poll on Children's Health.

18 Apr 2016

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

One in 5,000 babies is born missing a small amount of genetic material from the tip of chromosome 1, a region called 1p36. Missing genes in the 1p36 region is a relatively common cause of intellectual disability.

18 Apr 2016

False-positive mammogram results may have varied effects on subsequent screening behavior of women

Depending on when they received their last mammogram, women who receive a false-positive result are more or less likely to get screened at recommended intervals, according to preliminary findings from a University of North Carolina Comprehensive Cancer Center study.

18 Apr 2016

X linked News and Research

Imatinib-related symptom burden linked to adherence in Indian CML patients

Strength training lowers odds of death in older adults

Specific oral microbiome linked to pancreatic cancer risk

Study shows pulmonary alveolar proteinosis can be cured by single transfer of monocytes

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

DKFZ researchers develop new methods to study disease-relevant changes in production of oxidants

Researchers evaluate TBI-associated risk factors in older adults

Herceptin drugs for breast cancer linked with increased risk of congestive heart failure

Aspirin use linked with reduced risk of developing bile duct cancer

New therapy strategy for liver disease shows initial measureable success with norUrso

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

High dietary saturated fat intake may lead to prostate cancer aggressiveness

Animal study links female resilience to renal ischemia with protective effects of estrogen

Specific intake levels of xanthohumol reduces obesity, cholesterol and elevated glucose

Exposure to homicide during pregnancy linked to increased risk of prematurity, low birth weight

More than half of U.S. adults believe today's kids have diminished emotional and mental health

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

False-positive mammogram results may have varied effects on subsequent screening behavior of women

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